Free concentration and protein-binding ratio of ceftriaxone in cerebrospinal fluid in paediatric patients with purulent meningitis caused by Haemophilus influenzae type b

International Journal of Antimicrobial Agents

Volumn 35, Issue 5, 2010, Pages 512-513

  Hoshino, Tadashi ^a   Ishiwada, Naruhiko ^b   Kohno, Yoichi ^b  

^a CHIBA CHILDREN'S HOSPITAL   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CEFTRIAXONE;

BACTERIAL MENINGITIS; BACTERIAL STRAIN; BIOASSAY; CHILD; CLINICAL ARTICLE; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG EFFICACY; DRUG PROTEIN BINDING; HAEMOPHILUS INFLUENZAE TYPE B; HUMAN; INFANT; KIDNEY FUNCTION; LETTER; LIVER FUNCTION; MINIMUM INHIBITORY CONCENTRATION; PLEOCYTOSIS; PRESCHOOL CHILD; PRIORITY JOURNAL; ULTRAFILTRATION;

ANTI-BACTERIAL AGENTS; CEFTRIAXONE; CEREBROSPINAL FLUID; CHILD, PRESCHOOL; HAEMOPHILUS INFLUENZAE TYPE B; HUMANS; INFANT; MENINGITIS, HAEMOPHILUS; MICROBIAL SENSITIVITY TESTS; PROTEIN BINDING;

EID: 77949653873     PISSN: 09248579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2010.01.001     Document Type: Letter

References (8)

1. Tunkel A.R., Hartman B.J., Kaplan S.L., Kaufman B.A., Roos K.L., Scheld W.M., et al. Practice guidelines for the management of bacterial meningitis. Clin Infect Dis 2004, 39:1267-1284.
2. Craig W.A., Ebert S.C. Protein binding and its significance in antibacterial therapy. Infect Dis Clin North Am 1989, 3:407-414.
3. Goldwater P.N. Cefotaxime and ceftriaxone cerebrospinal fluid levels during treatment of bacterial meningitis in children. Int J Antimicrob Agents 2005, 26:408-411.
4. Hasegawa K., Kobayashi R., Takada E., Ono A., Chiba N., Morozumi M., et al. High prevalence of type b β-lactamase-non-producing ampicillin-resistant Haemophilus influenzae in meningitis: the situation in Japan where Hib vaccine has not been introduced. J Antimicrob Chemother 2006, 57:1077-1082.
5. Simon H.J., Yin E.J. Microbioassay of antimicrobial agents. Appl Microbiol 1970, 19:573-579.
6. Matzke G.R., Frye R.F., Joy M.S., Palevsky P.M. Determinants of ceftriaxone clearance by continuous venovenous hemofiltration and hemodialysis. Pharmacotherapy 2000, 20:635-643.
7. Clinical and Laboratory Standards Institute. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically; approved standard. 7th ed. Document M7-A7. Wayne, PA: CLSI; 2006.
8. Schmidt T., Täuber M.G. Pharmacodynamics of antibiotics in the therapy of meningitis: infection model observations. J Antimicrob Chemother 1993, 31(Suppl. D):61-70.