Formulation and in vitro evaluation of ketoprofen in palm oil esters nanoemulsion for topical delivery

Journal of Oleo Science

Volumn 59, Issue 4, 2010, Pages 223-228

  Sakeena, M H F ^a   Muthanna, F A ^a   Ghassan, Z A ^a   Kanakal, M M ^a   Elrashid, S M ^a   Munavvarf, S ^a   Azmin, M N ^a  

^a SCHOOL OF PHARMACEUTICAL SCIENCES   (Malaysia)

Author keywords

Ketoprofen; Palm oil esters; Topical delivery

Indexed keywords

EID: 77949640403     PISSN: 13458957     EISSN: 13473352     Source Type: Journal    
DOI: 10.5650/jos.59.223     Document Type: Article

References (19)

1. O'Brien, R.D. Fats and Oils: Formulating and Processing for Applications. CRC Press. Boca Raton (2004).
2. Keng, P.S.; Basri, M.; Zakaria, M.R.S.; Abdul Rahman, M.B.; Ariff, A.B.; Abbdul Rahman, R.N.Z.; Salleh, A.B. Newly synthesized palm esters for cosmetics industry. Indust. Crops and products 29(1), 37-44 (2009).
3. Gunawan, E.R.; Basri, M.; Abdulrahman, M.B.; Saleh, A.B.; Abdulrahman, R.N.Z. Lipase-catalyzed synthesis of palm-based wax esters. J. Oleo. Sci. 53(10), 471-477 (2004).
4. Keng, P.S.; Basri, M.; Ariff, A.B.; Abdul Rahman, M.B.; Abdul Rahman, R.N.Z.; Salleh, A.B. Scale-up synthesis of lipase-catalyzed palm esters in stirred-tank reactor. Bioresource Tech. 99, 6097-6104 (2008).
5. Keng, P.S.; Basri, M.; Abdul Rahman, M.B.; Salleh, A.B.; Abdul Rahman, R.N.Z.; Ariff, A.B. Optimization of palm-based wax esters production using statistical experiment design. J. Oleo. Sci. 54(10), 519-528 (2005).
6. Radzi, S.M.; Basri, M.; Salleh, A.B.; Ariff, A.B.; Mohammad, R.; Rahman, M.B.A.; Rahman, R.N.Z.A. Large scale production of liquid wax ester by immobilized lipase. J. Oleo Sci. 54, 203-209 (2005).
7. Steinke, G.; Kirchhoff, R.; Mukherjee, D. Lipase-catalyzed alcoholysis of crambe oil and camelina oil for the preparation of long chain esters. J. Am. Oil Chem. 77, 361-366 (2000).
8. Cordero, J.A.; Alarcon, L.; Escribano, E.; Obach, R.; Domenech, J. A comparative study of the transdermal penetration of a series of NSAIDs drug. J. Pharm. Sci. 86, 503-508 (1997).
9. Tadros, T.; Izquierdo, P.; Esquena, J.; Solans, C. Formation and stability of nanoemulsions. Adv. Colloid Interface Sci. 108(109), 303-318 (2004).
10. Uson, N.; Garcia, M.J.; Solans, C. Formation of water-in-oil (W/O) nanoemulsions in a water/mixed nonionic surfactant/oil systems prepared by a low-energy emulsification method. Colloids and Surfaces A: Physicochemical and Engineering aspects. 250, 415-421 (2004).
11. Kantor, T.G. Ketoprofen: A review of its pharmacologic and clinical properties. Pharmacotherapy 6, 93-103 (1986).
12. Valenta, C.; Almasi-Szabo, I. In vitro diffusion studies of ketoprofen transdermal therapeutic systems. Drug Dev. Ind. Pharm. 21, 1799-1805 (1995).
13. Sheikh, S.N.; Faiyaz, S.; Sushma, T.; Javed, A.; Sanjula, B.; Alka, A.; Roop, K.K.; Mushir, A. Formulation development and optimization using nanoemulsion technique: A technical note. AAPS PharmSciTech. 8(2), 28 (2007).
14. Valenta, C.; Wanka, M.; Heidlas, J. Evaluation of novel soya-lecithin formulations for dermal use containing ketoprofen as a model drug. J. Control Rel. 63, 165-173 (1999).
15. Sakeena, M.H.F.; Kanakal, M.M.; Abdulkarim, M.F.; Abdullah, G.Z.; Akram, J.; Munavvar Zubaid, A.S.; Azmin, M.N. Development and validation of ketoprofen analysis by high performance liquid chromatography. Malaysian J. Pharmacy 1(7), 61 (2009).
16. Abdulrahman, M.B.; Huan, Q.-Y.; Tejo, B.A.; Basri, M.; Salleh, A.B.; Rahman, R.N.Z.A. Self-assembly forma- tion of palm-based esters nanoemulsion: A molecular dynamics study. Chem. Physics Lett. 480, 220-224 (2009).
17. Basri, M.; Zakaria, M.R.S.; Huong, C.K.; Ismail, I.; Misran, M.; Kassim, A.; Salleh, A.B.; Abdul Rahman, R.N.Z.; AbdulRahman, M.B. Formation and stability of new palm based nanoemulsions. J. Biotechnol. 1364: S144-146 (2008).
18. Lawrence, M.J.; Rees, G.D.; Microemulsion-based media as novel drug delivery systems. Adv Drug Deliv Rev. 45, 89-121 (2000).
19. Shakeel, F.; Baboota, S.; Ahuja, A.; Ali, J.; Shafiq, S. Celecoxib nanoemulsion: Skin permeation mechanism and bioavailability assessment. J. Drug Targeting 16, 733-740 (2008).