Tumor-Associated Lymphangiogenesis in the Development of Conjunctival Squamous Cell Carcinoma

Ophthalmology

Volumn 117, Issue 4, 2010, Pages 649-658

  Heindl, Ludwig M ^a   Hofmann Rummelt, Carmen ^a   Adler, Werner ^b   Holbach, Leonard M ^a   Naumann, Gottfried O H ^a   Kruse, Friedrich E ^a   Cursiefen, Claus ^a  

^a UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

KI 67 ANTIGEN; LYMPHATIC VASCULAR ENDOTHELIAL HYALURONAN RECEPTOR 1; MITOMYCIN C; PODOPLANIN; RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER INVASION; CANCER RECURRENCE; CANCER SURVIVAL; CONJUNCTIVA SQUAMOUS CELL CARCINOMA; CONJUNCTIVA TUMOR; CONTROLLED STUDY; CRYOTHERAPY; DISEASE MARKER; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPHANGIOGENESIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; QUANTITATIVE ANALYSIS; SQUAMOUS CELL CARCINOMA;

ADULT; AGED; AGED, 80 AND OVER; CARCINOMA IN SITU; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; CONJUNCTIVAL NEOPLASMS; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOENZYME TECHNIQUES; KI-67 ANTIGEN; LYMPHANGIOGENESIS; LYMPHATIC VESSELS; MALE; MATCHED-PAIR ANALYSIS; MEMBRANE GLYCOPROTEINS; MIDDLE AGED; NEOPLASM INVASIVENESS; PRECANCEROUS CONDITIONS; PROPORTIONAL HAZARDS MODELS; RETROSPECTIVE STUDIES; VESICULAR TRANSPORT PROTEINS;

EID: 77949620530     PISSN: 01616420     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ophtha.2010.01.032     Document Type: Article

References (42)

1. Grossniklaus H.E., Green W.R., Luckenbach M., and Chan C.C. Conjunctival lesions in adults: a clinical and histopathological review. Cornea 6 (1987) 78-116
2. Lee G.A., and Hirst L.W. Ocular surface squamous neoplasia. Surv Ophthalmol 39 (1995) 429-450
3. Basti S., and Macsai M.S. Ocular surface squamous neoplasia: a review. Cornea 22 (2003) 687-704
4. Wittekind C., Holbach L.M., Ainbinder D.J., et al. Carcinoma of the conjunctiva. In: Edge S.B., Byrd D.R., Compton C.C., et al. (Eds). AJCC Cancer Staging Manual. 7th ed. (2009), Springer, New York 531-537
5. Holbach L.M., Pogorelov P., and Kruse F.E. Differential diagnosis and treatment options for conjunctival tumors. [in German]. Ophthalmologe 104 (2007) 521-538
6. Seitz B., Fischer M., Holbach L.M., and Naumann G.O. Differential diagnosis and prognosis of 112 excised epibulbar epithelial tumors. [in German]. Klin Monbl Augenheilkd 207 (1995) 239-246
7. Kruse F.E., Voelcker H.E., and Naumann G.O. Conjunctiva. [in German]. In: Naumann G.O. (Ed). Pathologie des Auges, 2 (1997), Springer, Berlin 379-506
8. Cursiefen C., Kruse F.E., and Naumann G.O. Cornea and limbus. In: Naumann G.O., Holbach L., and Kruse F.E. (Eds). Applied Pathology for Ophthalmic Microsurgeons (2008), Springer, Berlin 97-130
9. Tunc M., Char D.H., Crawford B., and Miller T. Intraepithelial and invasive squamous cell carcinoma of the conjunctiva: analysis of 60 cases. Br J Ophthalmol 83 (1999) 98-103
10. McKelvie P.A., Daniell M., McNab A., et al. Squamous cell carcinoma of the conjunctiva: a series of 26 cases. Br J Ophthalmol 86 (2002) 168-173
11. Erie J.C., Cambell R.J., and Liesegang T.J. Conjunctival and corneal intraepithelial and invasive neoplasia. Ophthalmology 93 (1986) 176-183
12. Scott I.U., Karp C.L., and Nuovo G.J. Human papillomavirus 16 and 18 expression in conjunctival intraepithelial neoplasia. Ophthalmology 109 (2002) 542-547
13. McDonnell J.M., Mayr A.J., and Martin W.J. DNA of human papillomavirus type 16 in dysplastic and malignant lesions of the conjunctiva and cornea. N Engl J Med 320 (1989) 1442-1446
14. Lee G.A., Williams G., Hirst L.W., and Green A.C. Risk factors in the development of ocular surface epithelial dysplasia. Ophthalmology 101 (1994) 360-364
15. Ng J., Coroneo M.T., Wakefield D., and Di Girolamo N. Ultraviolet radiation and the role of matrix metalloproteinases in the pathogenesis of ocular surface squamous neoplasia. Invest Ophthalmol Vis Sci 49 (2008) 5295-5306
16. Karp C.L., Scott I.U., Chang T.S., and Pflugfelder S.C. Conjunctival intraepithelial neoplasia: a possible marker for human immunodeficiency virus infection?. Arch Ophthalmol 114 (1996) 257-261
17. Mahomed A., and Chetty R. Human immunodeficiency virus infection, Bcl-2, p53 protein, and Ki-67 analysis in ocular surface squamous neoplasia. Arch Ophthalmol 120 (2002) 554-558
18. Guech-Ongey M., Engels E.A., Goedert J.J., et al. Elevated risk for squamous cell carcinoma of the conjunctiva among adults with AIDS in the United States. Int J Cancer 122 (2008) 2590-2593
19. Kallen C., Reinhard T., Schilgen G., et al. Atopic keratoconjunctivitis: probably a risk factor for the development of conjunctival carcinoma. [in German]. Ophthalmologe 100 (2003) 808-814
20. Schmack I., Kruse F.E., Bauer A., et al. Neurodermitis: a risk factor for the development of squamous cell carcinoma. [in German]. Ophthalmologe 103 (2006) 141-143
21. Napora C., Cohen E.J., Genvert G.I., et al. Factors associated with conjunctival intraepithelial neoplasia: a case control study. Ophthalmic Surg 21 (1990) 27-30
22. Stacker S.A., Achen M.G., Jussila L., et al. Lymphangiogenesis and cancer metastasis. Nat Rev Cancer 2 (2002) 573-583
23. Dadras S.S., Paul T., Bertoncini J., et al. Tumor lymphangiogenesis: a novel prognostic indicator for cutaneous melanoma metastasis and survival. Am J Pathol 162 (2003) 1951-1960
24. Streit M., and Detmar M. Angiogenesis, lymphangiogenesis, and melanoma metastasis. Oncogene 22 (2003) 3172-3179
25. Beasley N.J., Prevo R., Banerji S., et al. Intratumoral lymphangiogenesis and lymph node metastasis in head and neck cancer. Cancer Res 62 (2002) 1315-1320
26. Maula S.M., Luukkaa M., Grénman R., et al. Intratumoral lymphatics are essential for the metastatic spread and prognosis in squamous cell carcinomas of the head and neck region. Cancer Res 63 (2003) 1920-1926
27. Urabe A., Matsumoto T., Kimura M., et al. Grading system of lymphatic invasion according to D2-40 immunostaining is useful for the prediction of nodal metastasis in squamous cell carcinoma of the uterine cervix. Histopathology 49 (2006) 493-497
28. Longatto-Filho A., Pinheiro C., Pereira S.M., et al. Lymphatic vessel density and epithelial D2-40 immunoreactivity in pre-invasive and invasive lesions of the uterine cervix. Gynecol Oncol 107 (2007) 45-51
29. Heindl L.M., Hofmann T.N., Knorr H.L., et al. Intraocular lymphangiogenesis in malignant melanomas of the ciliary body with extraocular extension. Invest Ophthalmol Vis Sci 50 (2009) 1988-1995
30. Heindl L.M., Hofmann T.N., Adler W., et al. Intraocular tumor-associated lymphangiogenesis: a novel prognostic factor for ciliary body melanomas with extraocular extension?. Ophthalmology 117 (2010) 334-342
31. Zimmermann P., Dietrich T., Bock F., et al. Tumor-associated lymphangiogenesis in conjunctival malignant melanoma. Br J Ophthalmol 93 (2009) 1529-1534
32. Karkkainen M.J., and Petrova T.V. Vascular endothelial growth factor receptors in the regulation of angiogenesis and lymphangiogenesis. Oncogene 19 (2000) 5598-5605
33. Schoppmann S.F., Birner P., Stockl J., et al. Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. Am J Pathol 161 (2002) 947-956
34. Cursiefen C., Chen L., Borges L.P., et al. VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. J Clin Invest 113 (2004) 1040-1050
35. Padera T.P., Kadambi A., di Tomaso E., et al. Lymphatic metastasis in the absence of functional intratumor lymphatics. Science 296 (2002) 1883-1886
36. Cursiefen C., Schlotzer-Schrehardt U., Kuchle M., et al. Lymphatic vessels in vascularized human corneas: immunohistochemical investigation using LYVE-1 and podoplanin. Invest Ophthalmol Vis Sci 43 (2002) 2127-2135
37. Banerji S., Ni J., Wang S.X., et al. LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan. J Cell Biol 144 (1999) 789-801
38. Breiteneder-Geleff S., Soleiman A., Kowalski H., et al. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Am J Pathol 154 (1999) 385-394
39. Jackson D.G. New molecular markers for the study of tumour lymphangiogenesis. Anticancer Res 21 (2001) 4279-4283
40. Bock F., Onderka J., Dietrich T., et al. Bevacizumab as a potent inhibitor of inflammatory corneal angiogenesis and lymphangiogenesis. Invest Ophthalmol Vis Sci 48 (2007) 2545-2552
41. Cursiefen C., Bock F., Horn F.K., et al. GS-101 antisense oligonucleotide eye drops inhibit corneal neovascularization: interim results of a randomized phase II trial. Ophthalmology 116 (2009) 1630-1637
42. Teng C.C., Chin K.J., and Finger P.T. Subconjunctival ranibizumab for squamous cell carcinoma of the conjunctiva with corneal extension. [letter]. Br J Ophthalmol 93 (2009) 837-838