Is There still a role for desmopressin in children with primary monosymptomatic nocturnal enuresis?: A focus on safety issues

Drug Safety

Volumn 33, Issue 4, 2010, Pages 261-271

  Van De Walle, Johan ^a   Van Herzeele, Charlotte ^a   Raes, Ann ^a  

^a GHENT UNIVERSITY HOSPITAL   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

DESMOPRESSIN; IMIPRAMINE;

ABDOMINAL PAIN; AEROSOL; ALARM MONITORING; ANTIDIURESIS; CHILD; CONSCIOUSNESS; DIABETES INSIPIDUS; DOSE RESPONSE; DRUG BIOAVAILABILITY; DRUG DOSAGE FORM COMPARISON; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG FATALITY; DRUG INDICATION; DRUG INDUCED HEADACHE; DRUG MECHANISM; DRUG MISUSE; DRUG SAFETY; EPISTAXIS; FLUID INTAKE; FOOD AND DRUG ADMINISTRATION; HUMAN; HYPONATREMIA; LYOPHILISATE; MAXIMUM PLASMA CONCENTRATION; NAUSEA; NOCTURNAL ENURESIS; NOSE CONGESTION; NOTE; PATHOGENESIS; PRESCHOOL CHILD; PRESCRIPTION; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; RHINITIS; RISK ASSESSMENT; RISK FACTOR; SCHOOL CHILD; SEIZURE; SERUM OSMOLALITY; SIDE EFFECT; TABLET FORMULATION; UNSPECIFIED SIDE EFFECT; VOMITING; WATER INTOXICATION;

ADMINISTRATION, INTRANASAL; ADMINISTRATION, ORAL; AGED; ANTIDIURETIC AGENTS; CHILD; DEAMINO ARGININE VASOPRESSIN; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYPONATREMIA; NOCTURNAL ENURESIS; RISK FACTORS;

EID: 77949611806     PISSN: 01145916     EISSN: 11791942     Source Type: Journal    
DOI: 10.2165/11319110-000000000-00000     Document Type: Note

References (58)

1. Hjalmas K, Arnold T, Bower W, et al. Nocturnal enuresis: an international evidence based management strategy. J Urol 2004 Jun; 171 (6 Pt 2): 2545-2561
2. Yeung CK, Sreedhar B, Sihoe JD, et al. Differences in characteristics of nocturnal enuresis between children and adolescents: a critical appraisal from a large epidemiolo-gical study. BJU Int 2006 May; 97 (5): 1069-1073
3. Hinde M, Hjertonsson M, Broberg A. Low self esteem of children with enuresis: mental and social health compared in different groups. Lakartidningen 1995 Sep 6; 92 (36): 3225-3229
4. Joinson C, Heron J, Butler U, et al. Psychological differ-ences between children with and without soiling problems. Pediatrics 2006 May; 117 (5): 1575-1584
5. Hagglof B, Andren O, Bergstrom E, et al. Self-esteem before and after treatment in children with nocturnal enuresis and urinary incontinence. Scand J Urol Nephrol Suppl 1997; 183: 79-82
6. Wagner WG, Smith D, Norris WR. The psychological adjustment of enuretic children: a comparison of two types. J Pediatr Psychol 1988 Mar; 13 (1): 33-38
7. Hagglof B, Andren O, Bergstrom E, et al. Self-esteem in children with nocturnal enuresis and urinary incontinence: improvement of self-esteem after treatment. Eur Urol 1998; 33 Suppl. 3: 16-19
8. Theunis M, Van Hoecke E, Paesbrugge S, et al. Self-image and performance in children with nocturnal enuresis. Eur Urol 2002 Jun; 41 (6): 660-667, discussion 667
9. Butler R, McKenna S. Overcoming parental intolerance in childhood nocturnal enuresis: a survey of professional opinion. BJU Int 2002 Feb; 89 (3): 295-297
10. Yeung CK, Diao M, Sreedhar B. Cortical arousal in children with severe enuresis. N Engl J Med 2008 May 29; 358 (22): 2414-2415
11. Yuen-Keng Ng, His-Yang Wu, Kim Hung Lee, et al. Blad-der reduction surgery accelerates the appearance of spontaneous voiding in neonatal rats. J Urol 2010; 183: 370-377
12. Yeung CK. Bladder dysfunction, sleep arousal disturbance and impairment of CNS function in enuretic children. International Children's Continence Society (ICCS) Course and International Enuresis Symposium; 2007 Nov 30-Dec 2; Hong Kong
13. Dhondt K, Raes A, Hoebeke P, et al. Abnormal sleep ar-chitecture and refractory nocturnal enuresis. J Urol 2009 Oct; 182 (4 Suppl.): 1961-1965
14. Baeyens D, Roeyers H, Naert S, et al. The impact of ma-turation of brainstem inhibition on enuresis: a startle eye blink modification study with 2-year followup. J Urol 2007 Dec; 178 (6): 2621-2625
15. Jarvelin MR, Moilanen I, Vikevainen-Tervonen L, et al. Life changes and protective capacities in enuretic and non-enuretic children. J Child Psychol Psychiatry 1990; 31: 763-774
16. Rey JM, Hensley VR. Bedwetting and psychopathology in adolescents. J Paediatr Child Health 1995; 31: 508-512
17. Von Gontard A, Lehmkuhl G. Enuresis nocturna: neue Ergebnisse zu genetischen, pathophysiologischen und psychiatrischen Zusammenhangen. Prax Kinderpsychychol Kinderpsychiatr 1997; 46: 709-726
18. Klackenberg G. Nocturnal enuresis in a longitudinal per-spective. Acta Paediatr Scand 1981; 70: 453-457
19. Byrd RS, Weitzman M, Lanphear NE, et al. Bedwetting in US children: epidemiology and related behaviour problems. Pediatrics 1996; 98: 414-419
20. Fergusson DM, Horwood LJ. Nocturnal enuresis and be-havioural problems in adolescence: a 15-year longitudinal study. Pediatrics 1994; 94: 662-667
21. Nijman R, Bower W, Ellsworth P, et al. Diagnosis and management of urinary incontinence and encopresis in childhood. In: Abrams P, Cardozo L, Khoury S, et al., editors. Incontinence. 3rd ed. Plymouth: Health Publications Ltd, 2005: 965-1058
22. Neveus T, von Gontard A, Hoebeke P, et al. The standar-dization of terminology of lower urinary tract function in children and adolescents: report from the Standardisation Committee of the International Children's Continence Society. J Urol 2006 Jul; 176 (1): 314-324
23. Baeyens D, Roeyers H, Van Erdeghem S, et al. The pre-valence of attention deficit-hyperactivity disorder in children with nonmonosymptomatic nocturnal enuresis: a 4-year followup study. J Urol 2007 Dec; 178 (6): 2616-2620
24. Baeyens D, Roeyers H, Demeyere I, et al. Attention-deficit/hyperactivity disorder (ADHD) as a risk factor for persistent nocturnal enuresis in children: a two-year follow-up study. Acta Paediatrica 2005; 94: 1619-1625
25. Crimmins CR, Rathbun SR, Husmann DA. Management of urinary incontinence and nocturnal enuresis in attention-deficit hyperactivity disorder. J Urol 2003 Oct; 170 (4 Pt 1): 1347-1350
26. Baeyens D, Roeyers H, Hoebeke P, et al. The impact of attention deficit hyperactivity disorders on brainstem dysfunction in nocturnal enuresis. J Urol 2006 Aug; 176 (2): 744-748
27. Ornitz EM, Russell AT, Hanna GL, et al. Prepulse inhibi-tion of startle and the neurobiology of primary nocturnal enuresis. Biol Psychiatry 1999; 45: 1455-1466
28. Mahler B, Kamperis K, Schroeder M, et al. Sleep depriva-tion induces diuresis and natriuresis in healthy children. Aarhus: The Institute of Clinical Medicine, Faculty of Health Sciences, Aarhus University, 2009
29. Neveus T, Eggert P, Evans J, et al. Evaluation of and treat-ment for monosymptomatic enuresis: a standardization document from the International Children's Continence Society. J Urol 2010; 183: 441-447
30. Lackgren G, Lilja B, Neveus T, et al. Desmopressin in the treatment of severe nocturnal enuresis in adolescents: a 7-year follow-up study. Br J Urol 1998 May; 81 Suppl. 3: 17-23
31. Hjalmas K. SWEET, the Swedish Enuresis Trial. Scand J Urol Nephrol Suppl 1995; 173: 89-92, discussion 93
32. Norgaard JP, Rittig S, Djurhuus JC. Nocturnal enuresis: an approach to treatment based on pathogenesis. J Pediatr 1989 Apr; 114 (4 Pt 2): 705-710
33. Robson WL, Leung AK, Norgaard JP. The comparative safety of oral versus intranasal desmopressin for the treatment of children with nocturnal enuresis. J Urol 2007 Jul; 178 (1): 24-30
34. Lottmann H, Froeling F, Alloussi S, et al. A randomised comparison of oral desmopressin lyophilisate (MELT) and tablet formulations in children and adolescents with primary nocturnal enuresis. Int J Clin Pract 2007 Sep; 61 (9): 1454-1460
35. Butler RJ, Holland P, Gasson S, et al. Exploring potential mechanisms in alarm treatment for primary nocturnal en-uresis. Scand J Urol Nephrol 2007; 41 (5): 407-413
36. Oredsson AF, Jorgensen TM. Changes in nocturnal bladder capacity during treatment with the bell and pad for monosymptomatic nocturnal enuresis. J Urol 1998 Jul; 160 (1): 166-169
37. Muller D, Roehr CC, Eggert P. Comparative tolerability of drug treatment for nocturnal enuresis in children. Drug Saf 2004; 27 (10): 717-727
38. Glazener CM, Evans JH. Desmopressin for nocturnal enuresis in children. Cochrane Database Syst Rev 2002; (3): CD002112
39. Van Hoeck K, Bael A, Lax H, et al. Urine output rate and maximum volume voided in school-age children with and without nocturnal enuresis. J Pediatr 2007 Dec; 151 (6): 575-580
40. Lottmann H, Baydala L, Eggert P, et al. Long-term des-mopressin response in primary nocturnal enuresis: open-label, multinational study. Int J Clin Pract 2009 Jan; 63 (1): 35-45
41. Schulz-Juergensen S, Rieger M, Schaefer J, et al. Effect of 1-desamino-8-D-arginine vasopressin on prepulse inhibition of startle supports a central etiology of primary monosymptomatic enuresis. J Pediatr 2007 Dec; 151 (6): 571-574
42. Van de Walle J, Stockner M, Raes A, et al. Desmopressin 30 years in clinical use: a safety review. Curr Drug Saf 2007 Sep; 2 (3): 232-238
43. Jacquin P, Ouvry O, Alvin P. Fatal water intoxication in a young patient with anorexia nervosa. J Adolesc Health 1992 Nov; 13 (7): 631-633
44. Dehoorne JL, Raes AM, van Laecke E, et al. Desmopressin toxicity due to prolonged half-life in 18 patients with nocturnal enuresis. J Urol 2006 Aug; 176 (2): 754-758
45. A/S FP. Data on file, Ferring Pharmaceuticals 2005.
46. De Guchtenaere A, Raes A, Van de Walle C, et al. Evidence of partial anti-enuretic response related to poor pharma-codynamic effects of desmopressin nasal spray. J Urol 2009 Jan; 181 (1): 302-309, discussion 309
47. Fjellestad-Paulsen A, Hoglund P, Lundin S, et al. Pharma-cokinetics of 1-deamino-8-D-arginine vasopressin after various routes of administration in healthy volunteers. Clin Endocrinol (Oxf) 1993 Feb; 38 (2): 177-182
48. Van de Walle JG, Bogaert GA, Mattsson S, et al. A new fast-melting oral formulation of desmopressin: a pharmacody-namic study in children with primary nocturnal enuresis. BJU Int 2006 Mar; 97 (3): 603-609
49. Rittig S, Jensen AR, Jensen KT, et al. Effect of food intake on the pharmacokinetics and antidiuretic activity of oral desmopressin (DDAVP) in hydrated normal subjects. Clin Endocrinol (Oxf) 1998 Feb; 48 (2): 235-241
50. Richardson DW, Robinson AG. Desmopressin. Ann Intern Med 1985 Aug; 103 (2): 228-239
51. Rembratt A, Graugaard-Jensen C, Senderovitz T, et al. Pharmacokinetics and pharmacodynamics of desmo-pressin administered orally versus intravenously at daytime versus night-time in healthy men aged 55-70 years. Eur J Clin Pharmacol 2004 Aug; 60 (6): 397-402
52. Osterberg O, Savic RM, Karlsson MO, et al. Pharmacoki-netics of desmopressin administrated as an oral lyophilisate dosage form in children with primary nocturnal enuresis and healthy adults. J Clin Pharmacol 2006 Oct; 46 (10): 1204-1211
53. Rembratt A, Norgaard JP, Andersson KE. Desmopressin in elderly patients with nocturia: short-term safety and effects on urine output, sleep and voiding patterns. BJU Int 2003 May; 91 (7): 642-646
54. Rembratt A, Riis A, Norgaard JP. Desmopressin treatment in nocturia; an analysis of risk factors for hyponatremia. Neurourol Urodyn 2006; 25 (2): 105-109
55. Miller M. Fluid and electrolyte homeostasis in the elderly: physiological changes of ageing and clinical consequences. Baillieres Clin Endocrinol Metab 1997 Jul; 11 (2): 367-387
56. Van Herzeele C, Alova I, Evans J, et al. Poor compliance with primary nocturnal enuresis therapy may contribute to insufficient desmopressin response. J Urol 2009 Oct; 182 (4 Suppl.): 2045-2049
57. Rittig S, Jensen AR, Jensen KT, et al. Desmopressin tablet treatment: factors influencing gastrointestinal absorption. Scand J Urol Nephrol Suppl 1997; 183: 51-52
58. Matthiesen TB, Rittig S, Djurhuus JC, et al. A dose titra-tion, and an open 6-week efficacy and safety study of des-mopressin tablets in the management of nocturnal enuresis. J Urol 1994 Feb; 151 (2): 460-463