PS-SNAP, a practical polymer-supported nitrosation reagent in organic synthesis

Tetrahedron Letters

Volumn 51, Issue 17, 2010, Pages 2277-2280

  Roche, Didier ^a   Lardy, Claude ^b   Tournier, Lucie ^c   Prunier, Marc ^a   Valeur, Eric ^a  

^a Merck KGaA France   (France)

^b Edelris   (France)

^c Groupe Solabia   (France)

Author keywords

N Nitrosation; Polymer supported reagents; PS SNAP

Indexed keywords

ANILINE DERIVATIVE; N ACETYL S NITROSOPENICILLAMINE; POLYMER; SEC AMINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; FILTRATION; NITROSATION; SYNTHESIS;

EID: 77949570022     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2010.02.135     Document Type: Article

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24. Typical procedure: PS-SNAP (100 mg, 3 equiv) was added to a solution of 6 (10 mg, 0.03 mmol) in dichloromethane (3 ml) and the mixture was stirred with an orbital shaker for 140 h. After filtration, the resin was washed with dichloromethane and the filtrate was concentrated to afford 7 (10 mg, 91% yield) as a pale yellow solid.