The correlation among QTc interval, hyperglycaemia and the impaired autonomic activity

Autonomic Neuroscience: Basic and Clinical

Volumn 154, Issue 1-2, 2010, Pages 94-98

  Fiorentini, Alessandra ^a   Perciaccante, Antonio ^b   Valente, Rosita ^b   Paris, Alberto ^b   Serra, Pietro ^b   Tubani, Luigi ^b  

^a Montefiascone Hospital   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Heart rate variability; Hyperglycaemia; Hyperinsulinemia; QT interval

Indexed keywords

ACTION POTENTIAL; ADULT; ARTICLE; AUTONOMIC DYSFUNCTION; AUTONOMIC NERVOUS SYSTEM; CALCULATION; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; HEART RATE VARIABILITY; HOMEOSTASIS; HUMAN; HYPERGLYCEMIA; HYPERINSULINEMIA; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; QT INTERVAL; QT PROLONGATION;

ADULT; ANALYSIS OF VARIANCE; AUTONOMIC NERVOUS SYSTEM DISEASES; BLOOD GLUCOSE; BLOOD PRESSURE; ELECTROCARDIOGRAPHY; FEMALE; FUNCTIONAL LATERALITY; GLUCOSE TOLERANCE TEST; HEART RATE; HUMANS; HYPERGLYCEMIA; INSULIN RESISTANCE; LONG QT SYNDROME; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; STATISTICS AS TOPIC; TIME FACTORS;

EID: 77949541582     PISSN: 15660702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autneu.2009.11.006     Document Type: Article

References (32)

1. Ahnve S., and Vallin H. Influence of heart rate and inhibition of autonomic tone on the QT interval. Circulation 65 (1982) 435-439
2. Barr C.S., Naas A., Freeman M., Lang C.C., and Struthers A.D. QT dispersion and sudden unexpected death in chronic heart failure. Lancet 343 (1994) 327-329
3. Barron H.V., and Lesh M.D. Autonomic nervous system and sudden cardiac death. JACC 27 (1996) 1053-1060
4. Bazett H.C. An analysis of the time relationships of the electrocardiograms. Heart 7 (1920) 353-357
5. Browne K.F., Zipes D.P., Heger J.J., and Prystowsky E.N. Influence of the autonomic nervous system on the Q-T interval in man. Am. J. Cardiol. 50 (1982) 1099-1103
6. Brunner E.J., Hemingway H., Walker B.R., Page M., Clarke P., Juneja M., Shipley M.J., Kumari M., Andrew R., Seckl J.R., Papadopoulos A., Checkley S., Rumley A., Lowe G.D., Stansfeld S.A., and Marmot M.G. Adrenocortical, autonomic and inflammatory causes of the metabolic syndrome: nested case-control study. Circulation 106 21 (2002) 2659-2665
7. Cappato R., Alboni P., Pedroni P., Gilli G., and Antonioli G. Sympathetic and vagal influences on rate-dependent changes of QT interval in healthy subjects. Am. J. Cardiol. 68 (1991) 1188-1193
8. Dekker J.M., Feskens E.J., Schouten E.G., Klootwijk P., Pool J., and Kromhout D. QTc duration is associated with levels of insulin and glucose intolerance. The Zutphen Elderly Study. Diabetes 45 3 (1996) 376-380
9. el-Gamal A., Gallagher D., Nawras A., Gandhi P., Gomez J., Allison D.B., Steinberg J.S., Shumacher D., Blank R., and Heymsfield S.B. Effects of obesity on QT, RR and QTc intervals. Am. J. Cardiol. 75 (1995) 956-959
10. Esposito K., Marfella R., Gualdiero R., Carusone C., Pontillo A., Giugliano G., Nicoletti G., and Giugliano D. Sympathovagal bilance, nighttime blood pressare and QT intervals in normotensive obese women. Obesity Res. 11 5 (2003) 653-659
11. European Society of Hypertension-European Society of Cardiology Guidelines Committee. Guidelines for the management of arterial hypertension. J. Hypertens. 21 6 (2003) 1011-1053
12. Ewing D.J., Boland O., Neilson J.M., Cho C.G., and Clarke B.F. Autonomic neuropathy, QT interval lengthening and unexpected deaths in male diabetic patients. Diabetologia 34 (1991) 182-185
13. Festa A., D'Agostino R.J., Rautaharju P., Mykkanen L., and Haffner S.M. Relation of systemic blood pressure, left ventricular mass, insulin sensitivity and coronary artery disease to QT interval duration in non diabetic and type 2 diabetic subjects. Am. J. Cardiol. 86 10 (2000) 1117-1122 Nov
14. Giugliano D., Paolisso G., and Ceriello A. Oxidative stress and diabetic vascular complications. Diabetes Care 19 (1996) 257-267
15. Granger D.N. Ischemia-reperfusion: mechanism of microvascular dysfunction and the influence of risk factors for cardiovascular disease. Microcirculation 6 (1999) 167-168
16. Kempler P., Varadi A., Szalay F., and Tamas G. Autonomic neuropathy and corrected QT interval prolongation. There is a relationship. Diabetes Care 17 5 (1994) 454-456 May
17. La Rovere M.T., Bigger J.T., Marcus F.I., Mortara A., and Schwartz P.J. For the autonomic tone and reflexes after myocardial infarction investigators. Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction. Lancet 351 (1998) 478-484
18. Laitinen T., Vauhkonen I.K., Niskanen L.K., Hartikainen J.E., Lansimies E.A., Uusitupa M.I., and Laasko M. Power spectral analysis of heart rate variability during hyperinsulinemia in nondiabetic offspring of type 2 diabetic patients: evidence for possible early autonomic dysfunction in insulin-resistant subjects. Diabetes 48 6 (1999) 1295-1299
19. Laitinen T., Vauhkonen I., Niskanen L., Hartikainen J., Uusitupa M., and Laasko M. Prolonged corrected QT interval is associated with acute and chronic hyperinsulinemia in nondiabetic subjects. Diabetes Care 26 8 (2003) 2480-2481
20. Laitinen T., Lyyra-Laitinen T., Huopio H., Vauhkonen I., Halonen T., Hartikainen J., Niskanen L., and Laakso M. Electrocardiographic alterations during hyperinsulinemic hypoglycemia in healthy subjects. Ann. Noninvasive Electrocardiol. 13 2 (2008) 97-105 Apr
21. Marfella R., Nappo F., De Angelis L., Siniscalchi M., Rossi F., and Giugliano D. The effect of acute hyperglycaemia on QTc duration in healthy man. Diabetologia 43 (2000) 571-575
22. Matthews D.R., Hosker J.P., Rudenski A.S., Naylor B.A., Treacher D.F., and Turner R.C. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28 7 (1985) 412-419
23. Mirvis D.M. Spatial variation of QT intervals in normal persons and patients with acute myocardial infarction. JACC 5 (1985) 625-631
24. Perciaccante A., Fiorentini A., Paris A., Serra P., and Tubani L. Circadian rhythm of the autonomic nervous system in insulin resistant subjects with normoglycemia, impaired fasting glycemia, impaired glucose tolerance, type 2 diabetes mellitus. BMC Cardiovasc. Disord. 6 (2006) 19 May 2
25. Pikkujasma S.M., Huikuri H.V., Airaksinen K.E., Rantala A.O., Kauma H., Lilja M., Savolainen M.J., and Kesaniemi Y.A. Heart rate variability and baroreflex sensitivity in hypertensive subjects with and without metabolic features of insulin resistance syndrome. Am. J. Hypertens. 11 5 (1998) 523-531
26. Shin H.S., Lee W.Y., Kim S.W., Jung C.H., Rhee B.J., Kim B.J., Sung K.C., Kim B.S., Kang J.H., Lee M.H., and Park J.R. Sex difference in the relationship between insulin resistance and corrected QT interval in non diabetic subjects. Circ. J. 69 (2005) 409-413
27. Suzuki R., Tsumura K., Inoue T., Kishimoto H., and Morii H. QT interval prolongation in the patients receiving maintenance hemodialysis. Clin. Nephrol. 49 4 (1998) 240-244 Apr
28. Tesfamarian B., and Cohen R.A. Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am. J. Physiol. 263 (1992) H321-H326
29. Tibblin G, Eriksson CG, Bjurö T, Georgescu D, Svärdsudd C.Heart rate and heart rate variability. A risk factor for the development of ischemic heart disease in the 'Men Born in 1913 Study' - A ten years follow-up. IRCS Medical Science: Cardiovascular System; Social and Occupational Medicine 1975; 3: 95.
30. Veglio M., Giunti S., Stevens L.K., Fuller J.H., Perin P.C., and EURODIAB IDDM Complications Study Group. Prevalence of Q-T interval dispersion in type 1 diabetes and its relation with cardiac ischemia: the EURODIAB IDDM Complications Study Group. Diabetes Care 25 4 (2002) 702-707 Apr
31. Vlay S.C., Mallis G.I., Brown E.J., and Cohn P.F. Documented sudden cardiac death in prolonged QT syndrome. Arch. Int. Med. 144 (1984) 833-835
32. Whitsel E.A., Boyko E.J., and Siscovick D.S. Accuracy of QTc and QTI for detection of autonomic dysfunction. Ann. Noninvasive Electrocardiol. 4 (1999) 257-266