Shorter dialysis times are associated with higher mortality among incident hemodialysis patients

Kidney International

Volumn 77, Issue 7, 2010, Pages 630-636

  Brunelli, Steven M ^a,b   Chertow, Glenn M ^c   Ankers, Elizabeth D ^d   Lowrie, Edmund G ^e   Thadhani, Ravi ^b,d  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e NONE

Author keywords

Adequacy; Dialysis; Epidemiology; Mortality; Outcome; Session length

Indexed keywords

ADULT; ARTICLE; CLINICAL ASSESSMENT; FEMALE; HEMODIALYSIS PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK ASSESSMENT; SENSITIVITY ANALYSIS; SHORT COURSE THERAPY; STRUCTURE ANALYSIS; TREATMENT DURATION;

AGED; AGED, 80 AND OVER; FEMALE; HUMANS; KIDNEY FAILURE, CHRONIC; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RENAL DIALYSIS; UNITED STATES;

EID: 77949540188     PISSN: 00852538     EISSN: 15231755     Source Type: Journal    
DOI: 10.1038/ki.2009.523     Document Type: Article

References (34)

1. Gotch FA, Sargent JA. A mechanistic analysis of the National Cooperative Dialysis Study (NCDS). Kidney Int 1985; 28: 526-534.
2. Hemodialysis Adequacy 2006 Work Group. Clinical practice guidelines for hemodialysis adequacy, update 2006. Am J Kidney Dis 2006; 48(Suppl 1): S2-S90.
3. Lowrie EG, Chertow GM, Lew NL et al. The urea [clearance x dialysis time] product (Kt) as an outcome-based measure of hemodialysis dose. Kidney Int 1999; 56: 729-737.
4. Lowrie EG. Prescribing and monitoring hemodialysis dose. Kidney Int 2008; 74: 262-264.
5. Saran R, Bragg-Gresham JL, Levin NW et al. Longer treatment time and slower ultrafiltration in hemodialysis: associations with reduced mortality in the DOPPS. Kidney Int 2006; 69: 1222-1228.
6. Eloot S, Van Biesen W, Dhondt A et al. Impact of hemodialysis duration on the removal of uremic retention solutes. Kidney Int 2008; 73: 765-770.
7. Lowrie EG, Li Z, Ofsthun N et al. Measurement of dialyzer clearance, dialysis time, and body size: death risk relationships among patients. Kidney Int 2004; 66: 2077-2084.
8. Marshall MR, Byrne BG, Kerr PG et al. Associations of hemodialysis dose and session length with mortality risk in Australian and New Zealand patients. Kidney Int 2006; 69: 1229-1236.
9. Robins JM. Correction for non-compliance in equivalence trials. Stat Med 1998; 17: 269-302; discussion 387-1269
10. Robins JM, Blevins D, Ritter G et al. G-estimation of the effect of prophylaxis therapy for Pneumocystis carinii pneumonia on the survival of AIDS patients. Epidemiology 1992; 3: 319-336.
11. Robins JM, Hernan MA, Brumback B. Marginal structural models and causal inference in epidemiology. Epidemiology 2000; 11: 550-560.
12. Hernan MA, Brumback B, Robins JM. Marginal structural models to estimate the causal effect of zidovudine on the survival of HIV-positive men. Epidemiology 2000; 11: 561-570.
13. Owen Jr WF, Lew NL, Liu Y et al. The urea reduction ratio and serum albumin concentration as predictors of mortality in patients undergoing hemodialysis. N Engl J Med 1993; 329: 1001-1006.
14. Held PJ, Port FK, Wolfe RA et al. The dose of hemodialysis and patient mortality. Kidney Int 1996; 50: 550-556.
15. Teng M, Wolf M, Ofsthun MN et al. Activated injectable vitamin D and hemodialysis survival: a historical cohort study. J Am Soc Nephrol 2005; 16: 1115-1125.
16. Feldman HI, Joffe M, Robinson B et al. Administration of parenteral iron and mortality among hemodialysis patients. J Am Soc Nephrol 2004; 15: 1623-1632.
17. Weinhandl ED, Rao M, Gilbertson DT et al. Protective effect of intravenous levocarnitine on subsequent-month hospitalization among prevalent hemodialysis patients, 1998 to 2003. Am J Kidney Dis 2007; 50: 803-812.
18. Brunelli SM, Joffe MM, Israni RK et al. History-adjusted marginal structural analysis of the association between hemoglobin variability and mortality among chronic hemodialysis patients. Clin J Am Soc Nephrol 2008; 3: 777-782.
19. Lowrie EG, Laird NM, Parker TF et al. Effect of the hemodialysis prescription of patient morbidity: report from the National Cooperative Dialysis Study. N Engl J Med 1981; 305: 1176-1181.
20. Eknoyan G, Beck GJ, Cheung AK et al. Effect of dialysis dose and membrane flux in maintenance hemodialysis. N Engl J Med 2002; 347: 2010-2019.
21. Depner T, Daugirdas J, Greene T et al. Dialysis dose and the effect of gender and body size on outcome in the HEMO Study. Kidney Int 2004; 65: 1386-1394.
22. Charra B, Calemard M, Laurent G. Importance of treatment time and blood pressure control in achieving long-term survival on dialysis. Am J Nephrol 1996; 16: 35-44.
23. McGregor DO, Buttimore AL, Nicholls MG et al. Ambulatory blood pressure monitoring in patients receiving long, slow home haemodialysis. Nephrol Dial Transplant 1999; 14: 2676-2679.
24. Zoccali C, Benedetto FA, Mallamaci F et al. Left ventricular mass monitoring in the follow-up of dialysis patients: prognostic value of left ventricular hypertrophy progression. Kidney Int 2004; 65: 1492-1498.
25. Krane V, Heinrich F, Meesmann M et al. Electrocardiography and outcome in patients with diabetes mellitus on maintenance hemodialysis. Clin J Am Soc Nephrol 2009; 4: 394-400.
26. Ahmed A, Rich MW, Sanders PW et al. Chronic kidney disease associated mortality in diastolic versus systolic heart failure: a propensity matched study. Am J Cardiol 2007; 99: 393-398.
27. Aoki J, Ikari Y, Nakajima H et al. Clinical and pathologic characteristics of dilated cardiomyopathy in hemodialysis patients. Kidney Int 2005; 67: 333-340.
28. Gotch FA, Yarian S, Keen M. A kinetic survey of US hemodialysis prescriptions. Am J Kidney Dis 1990; 15: 511-515.
29. Suri RS, Garg AX, Chertow GM et al. Frequent Hemodialysis Network (FHN) randomized trials: study design. Kidney Int 2007; 71: 349-359.
30. Stegmayr BG, Brannstrom M, Bucht S et al. Minimized weight gain between hemodialysis contributes to a reduced risk of death. Int J Artif Organs 2006; 29: 675-680.
31. Kalantar-Zadeh K, Regidor DL, Kovesdy CP et al. Fluid retention is associated with cardiovascular mortality in patients undergoing long-term hemodialysis. Circulation 2009; 119: 671-679.
32. Holmberg B, Stegmayr BG. Cardiovascular conditions in hemodialysis patients may be worsened by extensive interdialytic weight gain. Hemodial Int 2009; 13: 27-31.
33. Movilli E, Gaggia P, Zubani R et al. Association between high ultrafiltration rates and mortality in uraemic patients on regular haemodialysis. A 5-year prospective observational multicentre study. Nephrol Dial Transplant 2007; 22: 3547-3552.
34. Thadhani R, Tonelli M. Cohort studies: marching forward. Clin J Am Soc Nephrol 2006; 1: 1117-1123.