Molecular cytogenetic analysis of cervical squamous cell carcinoma cells demonstrates discordant levels of numerical and structural chromosomal instability and identifies 'Selected' chromosome rearrangements

Cytogenetic and Genome Research

Volumn 127, Issue 1, 2010, Pages 9-20

  Foster, N ^a   Carter, S ^a   Ng, G ^a   Pett, M ^a   Roberts, I ^a   Coleman, N ^a  

^a HUTCHISON MRC RESEARCH CENTRE   (United Kingdom)

Author keywords

Carcinoma; Cervix; Chromosomal instability; Rearrangements; Selection

Indexed keywords

ARTICLE; CANCER CELL CULTURE; CARCINOMA CELL; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; CHROMOSOME IDENTIFICATION; CHROMOSOME REARRANGEMENT; FEMALE; GENETIC ASSOCIATION; GENETIC SELECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; METAPHASE CHROMOSOME; MOLECULAR GENETICS; NUMERICAL CHROMOSOME ABERRATION; PREVALENCE; PRIORITY JOURNAL; SOMATIC CELL GENETICS; STRUCTURAL CHROMOSOME ABERRATION; TUMOR; UTERINE CERVIX CARCINOMA;

CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CHROMOSOMAL INSTABILITY; FEMALE; GENE REARRANGEMENT; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; KARYOTYPING; PLOIDIES; UTERINE CERVICAL NEOPLASMS;

EID: 77949532872     PISSN: 14248581     EISSN: None     Source Type: Journal    
DOI: 10.1159/000290954     Document Type: Article

References (34)

1. Bayani J, Selvarajah S, Maire G, Vukovic B, Al-Romaih K, et al: Genomic mechanisms and measurement of structural and numerical instability in cancer cells. Semin Cancer Biol 17: 5-18 (2007).
2. Bayani J, Paderova J, Murphy J, Rosen B, Zielenska M, Squire JA: Distinct patterns of structural and numerical chromosomal instability characterize sporadic ovarian cancer. Neoplasia 10: 1057-1065 (2008).
3. Dall KL, Scarpini CG, Roberts I, Winder DM, Stanley MA, et al: Characterization of naturally occurring hpv16 integration sites isolated from cervical keratinocytes under noncompetitive conditions. Cancer Res 68: 8249-8259 (2008).
4. Deng W, Tsao SW, Kwok YK, Wong E, Huang XR, et al: Transforming growth factor beta1 promotes chromosomal instability in human papillomavirus 16 E6E7-infected cervical epithelial cells. Cancer Res 68: 7200-7209 (2008).
5. Duensing S, Munger K: The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability. Cancer Res 62: 7075-7082 (2002).
6. Duesberg P, Li R, Fabarius A, Hehlmann R: Aneuploidy and cancer: From correlation to causation. Contrib Microbiol 13: 16-44 (2006).
7. Garini Y, Macville M, du Manoir S, Buckwald RA, Lavi M, et al: Spectral karyotyping. Bioimaging 4: 66-72 (1996).
8. Gorringe KL, Chin SF, Pharoah P, Staines JM, Oliveira C, et al: Evidence that both genetic instability and selection contribute to the accumulation of chromosome alterations in cancer. Carcinogenesis 26: 923-930 (2005).
9. Harris CP, Lu XY, Narayan G, Singh B, Murty VV, Rao PH: Comprehensive molecular cytogenetic characterization of cervical cancer cell lines. Genes Chromosomes Cancer 36: 233-241 (2003).
10. Heim S, Mitelman F: Cancer Cytogenetics, 2nd ed (Wiley-Liss Inc, New York 1995).
11. Heim S, Mandahl N, Mitelman F: Genetic convergence and divergence in tumor progression. Cancer Res 48: 5911-5916 (1988).
12. Heng HH, Bremer SW, Stevens J, Ye KJ, Miller F, et al: Cancer progression by non-clonal chromosome aberrations. J Cell Biochem 98: 1424-1435 (2006).
13. ISCN (2005): An International System for Human Cytogenetic Nomenclature, Shaffer L, Tommerup N (eds). (S. Karger, Basel 2005).
14. James GK, Kalousek DK, Auersperg N: Karyotypic analysis of two related cervical carcinoma cell lines that contain human papillomavirus type 18 DNA and express divergent differentiation. Cancer Genet Cytogenet 38: 53-60 (1989).
15. Lengauer C, Kinzler KW, Vogelstein B: Genetic instability in colorectal cancers. Nature 386: 623-627 (1997).
16. Mitelman F, Johansson B, Mertens F: Catalog of Chromsome Aberrations in Cancer, 5th ed (Wiley-Liss, New York 1994).
17. Morris M, Tortolero-Luna G, Malpica A, Baker VV, Cook E, et al: Cervical intraepithelial neoplasia and cervical cancer. Obstet Gynecol Clin North Am 23: 347-410 (1996).
18. Nacheva EP, Gribble S, Andrews K, Wienberg J, Grace CD: Screening for specific chromosome involvement in hematological malignancies using a set of 7 chromosome painting probes. An alternative approach for chromosome analysis using standard fish instrumentation. Cancer Genet Cytogenet 122: 65-72 (2000).
19. Ng G, Winder D, Muralidhar B, Gooding E, Roberts I, et al: Gain and overexpression of the oncostatin M receptor occur frequently in cervical squamous cell carcinoma and are associated with adverse clinical outcome. J Pathol 212: 325-334 (2007).
20. Pett M, Coleman N: Integration of high-risk human papillomavirus: A key event in cervical carcinogenesis? J Pathol 212: 356-367 (2007).
21. Pett MR, Alazawi WO, Roberts I, Dowen S, Smith DI, et al: Acquisition of high-level chromosomal instability is associated with integration of human papillomavirus type 16 in cervical keratinocytes. Cancer Res 64: 1359-1368 (2004).
22. Plug-DeMaggio AW, Sundsvold T, Wurscher MA, Koop JI, Klingelhutz AJ, McDougall JK: Telomere erosion and chromosomal instability in cells expressing the HPV oncogene 16E6. Oncogene 23: 3561-3571 (2004).
23. Rajagopalan H, Nowak MA, Vogelstein B, Lengauer C: The significance of unstable chromosomes in colorectal cancer. Nat Rev Cancer 3: 695-701 (2003).
24. Rao PH, Cigudosa JC, Ning Y, Calasanz MJ, Iida S, et al: Multicolor spectral karyotyping identifies new recurring breakpoints and translocations in multiple myeloma. Blood 92: 1743-1748 (1998).
25. Roberts I, Wienberg J, Nacheva E, Grace C, Griffin D, Coleman N: Novel method for the production of multiple colour chromosome paints for use in karyotyping by fluorescence in situ hybridisation. Genes Chromosomes Cancer 25: 241-250 (1999).
26. Roschke AV, Stover K, Tonon G, Schaffer AA, Kirsch IR: Stable karyotypes in epithelial cancer cell lines despite high rates of ongoing structural and numerical chromosomal instability. Neoplasia 4: 19-31 (2002).
27. Roschke AV, Tonon G, Gehlhaus KS, McTyre N, Bussey KJ, et al: Karyotypic complexity of the NCI-60 drug-screening panel. Cancer Res 63: 8634-8647 (2003).
28. Someya M, Sakata K, Matsumoto Y, Yamamoto H, Monobe M, et al: The association of DNAdependent protein kinase activity with chromosomal instability and risk of cancer. Carcinogenesis 27: 117-122 (2006).
29. Szuhai K, Bezrookove V, Wiegant J, Vrolijk J, Dirks RW, et al: Simultaneous molecular karyotyping and mapping of viral DNA integration sites by 25-color COBRA-FISH. Genes Chromosomes Cancer 28: 92-97 (2000).
30. Tomlinson IP, Novelli MR, Bodmer WF: The mutation rate and cancer. Proc Natl Acad Sci USA 93: 14800-14803 (1996).
31. Trent JM, Kaneko Y, Mitelman F: Report of the committee on structural chromosome changes in neoplasia. Cytogenet Cell Genet 51: 533-562 (1989).
32. Ye CJ, Stevens JB, Liu G, Bremer SW, Jaiswal AS, et al: Genome based cell population heterogeneity promotes tumorigenicity: The evolutionary mechanism of cancer. J Cell Physiol 219: 288-300 (2009).
33. Zimonjic DB, Simpson S, Popescu NC, DiPaolo JA: Molecular cytogenetics of human papillomavirus-negative cervical carcinoma cell lines. Cancer Genet Cytogenet 82: 1-8 (1995).
34. zur Hausen H: Papillomaviruses causing cancer: Evasion from host-cell control in early events in carcinogenesis. J Natl Cancer Inst 92: 690-698 (2000).