Purified T-depleted, CD34+ peripheral blood and bone marrow cell transplantation from haploidentical mother to child with thalassemia

Blood

Volumn 115, Issue 6, 2010, Pages 1296-1302

  Sodani, Pietro ^a   Isgrò, Antonella ^a   Gaziev, Javid ^a   Polchi, Paola ^a   Paciaroni, Katia ^a   Marziali, Marco ^a   Simone, Maria Domenica ^a   Roveda, Andrea ^a   Montuoro, Aldo ^a   Alfieri, Cecilia ^a   De Angelis, Gioia ^a   Gallucci, Cristiano ^a   Erer, Buket ^a   Isacchi, Giancarlo ^b   Zinno, Francesco ^b   Adorno, Gaspare ^a   Lanti, Alessandro ^a   Faulkner, Lawrence ^c   Testi, Manuela ^d   Andreani, Marco ^d   Lucarelli, Guido ^a   more..

^a TOR VERGATA UNIVERSITY HOSPITAL   (Italy)

^b UNIVERSITY OF ROME TOR VERGATA   (Italy)

^c UNIVERSITY OF FLORENCE   (Italy)

^d International Centre for Transplantation in Thalassemia   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACICLOVIR; AMPHOTERICIN B; AZATHIOPRINE; BUSULFAN; CD34 ANTIBODY; CYCLOPHOSPHAMIDE; ERYTHROPOIETIN; FLUDARABINE; GRANULOCYTE COLONY STIMULATING FACTOR; HYDROXYUREA; THIOTEPA; THYMOCYTE ANTIBODY; CD34 ANTIGEN; HLA ANTIGEN;

ADOLESCENT; ARTICLE; BLOOD; BRAIN LYMPHOMA; CHILD; CHIMERA; CLINICAL ARTICLE; CONTROLLED STUDY; EPSTEIN BARR VIRUS; FEMALE; FOLLOW UP; GRAFT FAILURE; HAPLOIDY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; MALE; MOTHER; PNEUMONIA; PRESCHOOL CHILD; PRIORITY JOURNAL; PROPHYLAXIS; SCHOOL CHILD; STEM CELL MOBILIZATION; T CELL DEPLETION; THALASSEMIA; TREATMENT DURATION; VIRUS INFECTION; ADULT; ALLOTRANSPLANTATION; BONE MARROW TRANSPLANTATION; FEASIBILITY STUDY; FLOW CYTOMETRY; FLUORESCENCE IN SITU HYBRIDIZATION; GRAFT SURVIVAL; GRAFT VERSUS HOST REACTION; IMMUNOLOGY; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE DEPLETION; METABOLISM; MIDDLE AGED; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PILOT STUDY; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDY; T LYMPHOCYTE;

ADOLESCENT; ADULT; ANTIGENS, CD34; BONE MARROW TRANSPLANTATION; CHILD; CHILD, PRESCHOOL; FEASIBILITY STUDIES; FLOW CYTOMETRY; GRAFT SURVIVAL; GRAFT VS HOST DISEASE; HLA ANTIGENS; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; LYMPHOCYTE DEPLETION; MIDDLE AGED; MOTHERS; PERIPHERAL BLOOD STEM CELL TRANSPLANTATION; PILOT PROJECTS; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; T-LYMPHOCYTES; THALASSEMIA; TRANSPLANTATION CONDITIONING; TRANSPLANTATION, HOMOLOGOUS; YOUNG ADULT;

EID: 77949532641     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-05-218982     Document Type: Article

References (21)

1. Lucarelli G, Clift R, Galimberti M, et al. Marrow transplantation for patients with thalassemia: results in class 3 patients. Blood. 1996;87(5):2082-2088. (Pubitemid 26068926)
2. Lucarelli G, Galimberti M, Giardini C, et al. Bone marrow transplantation in thalassemia. Ann N Y Acad Sci. 1998;850:270-275.
3. La Nasa G, Argiolu F, Giardini C, et al. Unrelated bone marrow transplantation for beta-thalassemia patients: the experience of the Italian Bone Marrow Transplant group. Ann N Y Acad Sci. 2005;1054:186-195. (Pubitemid 43031024)
4. Aversa F, Tabilio A, Terenzi A, et al. Successful engraftment of T-cell depleted haploidentical "three-loci" incompatible transplants in leukemia patients by addition of recombinant human granulocyte colony-stimulating factor-mobilized peripheral blood progenitor cells to bone marrow inoculum. Blood. 1994;84(11):3948-3955. (Pubitemid 24362497)
5. Sodani P, Polchi P, Erer B, et al. Haploidentical T depleted peripheral blood and stem cells plus bone marrow transplantation from mother to child with thalassemia disease. Hematol J. 2003;4(suppl 2):Poster Section no. 206.
6. Sodani P, Polchi P, Erer B, et al. Haploidentical T depleted peripheral blood and stem cells plus bone marrow transplantation from mother to child with thalassemia disease. Haematologica. 2003;88(suppl 15):Poster section no. 233.
7. Sodani P, Gaziev D, Polchi P, et al. A new approach for bone marrow transplantation in class 3 thalassemic patients aged less than 17 years. Blood. 2004;104(4):1201-1203. (Pubitemid 39038044)
8. Lucarelli G, Galimberti M, Polchi P, et al. Marrow transplantation in patients with thalassemia responsive to iron chelation therapy. N Engl J Med. 1993;329(12):840-844.
9. Scharf SJ, Smith AG, Hansen JA, et al. Quantitative determination of bone marrow transplant engraftment using fluorescent polymerase chain reaction primers for human identity markers. Blood. 1995;85(7):1954-1963.
10. Andreani M, Manna M, Lucarelli G, et al. Persistence of mixed chimerism in patients transplanted for the treatment of thalassemia. Blood. 1996;87(8):3494-3499. (Pubitemid 26115383)
11. Kalbfleisch JD, Prentice RL. The Statistical Analysis of Failure Time Data. New York, NY: John Wiley & Sons; 1980.
12. Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc. 1958;53:457-481.
13. Andreani M, Manna M, Lucarelli G, et al. Persistence of mixed chimerism in patients transplanted for the treatment of thalassemia. Blood. 1996;87(8):3494-3499. (Pubitemid 26115383)
14. Di Bartolomeo P, Santarone S, Di Bartolomeo E, et al. A. Long-term of survival in patients with thalassemia major treated with bone marrow transplantation. Am J Hematol. 2008;83(7):528-530.
15. Evans PC, Lambert N, Maloney S, Furst DE, Moore JM, Nelson JL. Long-term fetal microchimerism in peripheral blood mononuclear cell subsets in healthy women and women with scleroderma. Blood. 1999;93(6):2033-2037. (Pubitemid 29128506)
16. Ichinohe T, Maruya E, Saji H. Long-term feto-maternal microchimerism: nature's hidden clue for alternative donor hematopoietic cell transplantation? Int J Hematol. 2002;76(3):229-237. (Pubitemid 43020311)
17. van Rood J, Loberiza FR, Zhang MJ, et al. Effect of tolerance to noninherited maternal antigens on the occurrence of graft-versus-host disease after bone marrow transplantation from a parent an HLA-haploidentical sibling. Blood. 2002;99:1572-1577.
18. Polchi P, Lucarelli G, Galimberti M, et al. Haploidentical bone marrow transplantation from mother to child with advanced leukemia. Bone Marrow Transplant. 1995;16(4):529-535.
19. Reisner Y, Martelli MF. Bone marrow transplantation across HLA barriers by increasing the number of transplanted cells. Immunol Today. 1995;16(9):437-440.
20. Aversa F, Tabilio A, Velardi A, et al. Treatment of high-risk acute leukemia with T-cell-depleted stem cells from related donors with one fully mismatched HLA haplotype. N Engl J Med. 1998;339(17):1186-1193. (Pubitemid 28482127)
21. Isgrò A, Sodani P, Marziali M, et al. Early T cell recovery of thymus-derived naïve T cells and NK-cells in pediatrics patients after T-cell-depleted HLA-haploidentical stem cell transplantation for thalassemia [abstract]. Blood. 2007;110(1):336.