Association study of ghrelin receptor gene polymorphisms in rheumatoid arthritis

Clinical and Experimental Rheumatology

Volumn 28, Issue 1, 2010, Pages 25-29

  Robledo, Gema ^a   Rueda, Blanca ^a   Gonzalez Gay, Miguel A ^b   Fernández, Benjamín ^c   Lamas, José R ^c   Balsa, Alejandro ^c   Pascual Salcedo, Dora ^c   García, Antonio ^d   Raya, Enrique ^e   Martín, Javier ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b HOSPITAL XERAL CALDE   (Spain)

^c HOSPITAL CLÍNICO SAN CARLOS   (Spain)

^d HOSPITAL UNIVERSITARIO VIRGEN DE LAS NIEVES   (Spain)

^e HOSPITAL UNIVERSITARIO SAN CECILIO   (Spain)

Author keywords

Ghrelin; Ghrelin receptor (GHSR) gene; Rheumatoid arthritis; Single nucleotide polymorphism

Indexed keywords

CYCLIC CITRULLINATED PEPTIDE ANTIBODY; GHRELIN RECEPTOR; RHEUMATOID FACTOR;

ARTICLE; CAUCASIAN; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE LINKAGE DISEQUILIBRIUM; GENETIC MARKER; GENETIC SCREENING; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; LINKAGE ANALYSIS; MAJOR CLINICAL STUDY; NEPHELOMETRY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; EPITOPES; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; PEPTIDES, CYCLIC; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, GHRELIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RHEUMATOID FACTOR; SPAIN;

EID: 77949511307     PISSN: 0392856X     EISSN: 1593098X     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. FIRESTEIN GS: Evolving concepts of rheumatoid arthritis. Nature 2003; 423: 356-61.
2. OROZCO G, RUEDA B, MARTIN J: Genetic basis of rheumatoid arthritis. Biomed Pharmacother 2006; 60: 656-62.
3. NEWTON JL, HARNEY SM, WORDSWORTH BP, BROWN MA: A review of the MHC genetics of rheumatoid arthritis. Genes Immun 2004; 5:151-7.
4. COENEN MJ, GREGERSEN PK: Rheumatoid arthritis: a view of the current genetic landscape. Genes Immun 2009; 10: 101-11.
5. BOHANEC GRABAR P, LOGAR D, TOMSIC M, ROZMAN B, DOLZAN V: Genetic polymorphisms of glutathione S-transferases and disease activity of rheumatoid arthritis. Clin Exp Rheumatol 2009; 27: 229-36.
6. LO SF, HUANG CM, LIN HC, CHEN WC, TSAI CH, TSAI FJ: Cytokine (IL-6) and chemokine (IL-8) gene polymorphisms among rheumatoid arthritis patients in Taiwan. Clin Exp Rheumatol 2008; 26: 632-7. 7. RUBINI M, PADOVAN M, BARICORDI O, FOTINIDI M, GOVONI M, TROTTA F: The c.1298A>C polymorphism in the methylenetetrahydrofolate reductase gene is associated with rheumatoid arthritis susceptibility in Italian patients. Clin Exp Rheumatol 2008; 26: 163.
7. KOJIMA M, HOSODA H, DATE Y, NAKAZATO M, MATSUO H, KANGAWA K: Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-60.
8. HOSODA H, KOJIMA M, KANGAWA K: Biological, physiological, and pharmacological aspects of ghrelin. J Pharmacol Sci 2006; 100: 398-410.
9. VAN DER LELY AJ, TSCHOP M, HEIMAN ML, GHIGO E: Biological, physiological, pathophysiological, and pharmacological aspects of ghrelin. Endocr Rev 2004; 25: 426-57.
10. SMITH RG, JIANG H, SUN Y: Developments in ghrelin biology and potential clinical relevance. Trends Endocrinol Metab 2005; 16: 436-42.
11. GONZALEZ-REY E, CHORNY A, DEL MORAL RG, VARELA N, DELGADO M: Therapeutic effect of cortistatin on experimental arthritis by downregulating inflammatory and Th1 responses. Ann Rheum Dis 2007; 66: 582-8.
12. DIXIT VD, SCHAFFER EM, PYLE RS et al.: Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells. J Clin Invest 2004; 114: 57-66.
13. HATTORI N, SAITO T, YAGYU T, JIANG BH, KITAGAWA K, INAGAKI C: GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils. J Clin Endocrinol Metab 2001; 8: 4284-91.
14. LI WG, GAVRILA D, LIU X et al.: Ghrelin inhibits proinflammatory responses and nuclear factor-kappaB activation in human endothelial cells. Circulation 2004; 109: 2221-6.
15. CORNELIS F, FAURE S, MARTINEZ M et al.: New susceptibility locus for rheumatoid arthritis suggested by a genome-wide linkage study. Proc Natl Acad Sci U S A 1998; 95: 10746-50.
16. SUN Y, AHMED S, SMITH RG: Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol 2003; 23: 7973-81.
17. HOWARD AD, FEIGHNER SD, CULLY DF et al.: A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996; 273: 974-7.
18. BAESSLER A, HASINOFF MJ, FISCHER M et al.: Genetic linkage and association of the growth hormone secretagogue receptor (ghrelin receptor) gene in human obesity. Diabetes 2005; 54: 259-67.
19. BAESSLER A, FISCHER M, MAYER B et al.: Epistatic interaction between haplotypes of the ghrelin ligand and receptor genes influence susceptibility to myocardial infarction and coronary artery disease. Hum Mol Genet 2007; 16: 887-99.
20. BAESSLER A, KWITEK AE, FISCHER M et al.: Association of the Ghrelin receptor gene region with left ventricular hypertrophy in the general population: results of the MONICA/ KORA Augsburg Echocardiographic Substudy. Hypertension 2006; 47: 920-7.
21. ARNETT FC, EDWORTHY SM, BLOCH DA et al.: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
22. GONZALEZ-GAY MA, GARCIA-UNZUETA MT, BERJA A et al.: Anti-tumour necrosis factor alpha therapy modulates ghrelin in patients with severe rheumatoid arthritis. Ann Rheum Dis 2008; 67: 1644-6.
23. PETERSENN S, RASCH AC, PENSHORN M, BEIL FU, SCHULTE HM: Genomic structure and transcriptional regulation of the human growth hormone secretagogue receptor. Endocrinology 2001; 142: 2649-59.
24. DOSSUS L, MCKAY JD, CANZIAN F et al.: Polymorphisms of genes coding for ghrelin and its receptor in relation to anthropometry, circulating levels of IGF-I and IGFBP-3, and breast cancer risk: a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). Carcinogenesis 2008; 29: 1360-6.
25. POSTHUMUS MD, LIMBURG PC, WESTRA J et al.: Serum levels of matrix metalloproteinase-3 in relation to the development of radiological damage in patients with early rheumatoid arthritis. Rheumatology (Oxford) 1999; 38: 1081-7.
26. rd: C/EBP beta in rheumatoid arthritis: correlation with inflammation, not disease specificity. Clin Immunol 1999; 91: 271-82.