Medium and process optimization for high yield, high density suspension cultures: From low throughput spinner flasks to high throughput millilitre reactors

BioProcess International

Volumn 7, Issue SUPPL.1, 2009, Pages 12-17

  De Jesus, Maria Joao ^a   Wurm, Florian Maria ^a  

^a EXCELLGENE SA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BIOREACTOR; BIOTECHNOLOGY; CELL POPULATION; HIGH THROUGHPUT SCREENING; PHYSICOCHEMICAL MODEL; PROCESS OPTIMIZATION; SHORT SURVEY; SUSPENSION CELL CULTURE;

EID: 77949507484     PISSN: 15426319     EISSN: None     Source Type: Trade Journal    
DOI: None     Document Type: Short Survey

References (5)

1. Wurm FM. Production of Recombinant Protein Therapeutics in Cultivated Mammalian Cells. Nature Biotech. 22 2004: 1393-1398.
2. Griffiths B. Scaling Up of Animal Cell Cultures. Animal Cell Culture. IRL Press: Oxford, UK, 1986: 33-69.
3. Scharfenberg K, Wagner R. A Reliable Strategy for the Achievement of Cell Lines Growing in Protein-Free Medium. Animal Cell Technology: Developments Towards the 21st Century. Springer, Dordrecht, the Netherlands, 1995: 619-623.
4. De Jesus MJ, et al. TubeSpin Satellites: A Fast Track Approach for Process Development with Animal Cells Using Shaking Technology. Biochem. Eng. J. 17 2004: 217-223.
5. Stettler M, et al. 1000 Non-Instrumented Bioreactors in a Week. Cell Technology for Cell Products. Springer, Dordrecht, the Netherlands, 2007: 489-495.