Delta-like 1 expression promotes goblet cell differentiation in Notch-inactivated human colonic epithelial cells

Biochemical and Biophysical Research Communications

Volumn 393, Issue 4, 2010, Pages 662-667

  Akiyama, Junko ^a   Okamoto, Ryuichi ^a   Iwasaki, Michiko ^a   Zheng, Xiu ^a   Yui, Shiro ^a   Tsuchiya, Kiichiro ^a   Nakamura, Tetsuya ^a   Watanabe, Mamoru ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

Author keywords

Atoh1; Dll1; Goblet cell; MUC2; Notch signaling

Indexed keywords

CELL PROTEIN; CIS ACTING ELEMENT; DELTA LIKE 1 PROTEIN; DELTA LIKE 4 PROTEIN; MUCIN 2; NOTCH RECEPTOR; PROTEIN ATOH1; TRANSCRIPTION FACTOR HES 1; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; COLON MUCOSA; DOWN REGULATION; EPITHELIUM CELL; GOBLET CELL; HUMAN; HUMAN TISSUE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; CELL DIFFERENTIATION; CELLS, CULTURED; COLON; GENE KNOCKDOWN TECHNIQUES; GOBLET CELLS; HOMEODOMAIN PROTEINS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 77949492378     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.02.048     Document Type: Article

References (19)

1. Okamoto R., and Watanabe M. Cellular and molecular mechanisms of the epithelial repair in IBD. Dig. Dis. Sci. 50 Suppl. 1 (2005) S34-S38
2. Van der Sluis M., De Koning B.A., De Bruijn A.C., Velcich A., Meijerink J.P., Van Goudoever J.B., Buller H.A., Dekker J., Van Seuningen I., Renes I.B., and Einerhand A.W. Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protection. Gastroenterology 131 (2006) 117-129
3. Velcich A., Yang W., Heyer J., Fragale A., Nicholas C., Viani S., Kucherlapati R., Lipkin M., Yang K., and Augenlicht L. Colorectal cancer in mice genetically deficient in the mucin Muc2. Science 295 (2002) 1726-1729
4. Crosnier C., Stamataki D., and Lewis J. Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat. Rev. Genet. 7 (2006) 349-359
5. Park E.T., Oh H.K., Gum Jr. J.R., Crawley S.C., Kakar S., Engel J., Leow C.C., Gao W.Q., and Kim Y.S. HATH1 expression in mucinous cancers of the colorectum and related lesions. Clin. Cancer Res. 12 (2006) 5403-5410
6. Tsuchiya K., Nakamura T., Okamoto R., Kanai T., and Watanabe M. Reciprocal targeting of Hath1 and beta-catenin by Wnt glycogen synthase kinase 3beta in human colon cancer. Gastroenterology 132 (2007) 208-220
7. Aragaki M., Tsuchiya K., Okamoto R., Yoshioka S., Nakamura T., Sakamoto N., Kanai T., and Watanabe M. Proteasomal degradation of Atoh1 by aberrant Wnt signaling maintains the undifferentiated state of colon cancer. Biochem. Biophys. Res. Commun. 368 (2008) 923-929
8. van Den Brink G.R., de Santa Barbara P., and Roberts D.J. Development. Epithelial cell differentiation - a Mather of choice. Science 294 (2001) 2115-2116
9. Okamoto R., Tsuchiya K., Nemoto Y., Akiyama J., Nakamura T., Kanai T., and Watanabe M. Requirement of Notch activation during regeneration of the intestinal epithelia. Am. J. Physiol. Gastrointest. Liver Physiol. 296 (2009) G23-G35
10. D'Souza B., Miyamoto A., and Weinmaster G. The many facets of Notch ligands. Oncogene 27 (2008) 5148-5167
11. Schroder N., and Gossler A. Expression of Notch pathway components in fetal and adult mouse small intestine. Gene Expression Patterns 2 (2002) 247-250
12. Crosnier C., Vargesson N., Gschmeissner S., Ariza-McNaughton L., Morrison A., and Lewis J. Delta-Notch signalling controls commitment to a secretory fate in the zebrafish intestine. Development 132 (2005) 1093-1104
13. Oshima S., Nakamura T., Namiki S., Okada E., Tsuchiya K., Okamoto R., Yamazaki M., Yokota T., Aida M., Yamaguchi Y., Kanai T., Handa H., and Watanabe M. Interferon regulatory factor 1 (IRF-1) and IRF-2 distinctively up-regulate gene expression and production of interleukin-7 in human intestinal epithelial cells. Mol. Cell Biol. 24 (2004) 6298-6310
14. J. Wu, J. S. Tung, E.D. Thorsett, M.A. Pleiss, J.S. Nissen, J. Neitz, L.H. Latimer, V. John, S. Freedman, inventors. US patent WO-1998028268, February 7, 1998.
15. Matsumoto T., Okamoto R., Yajima T., Mori T., Okamoto S., Ikeda Y., Mukai M., Yamazaki M., Oshima S., Tsuchiya K., Nakamura T., Kanai T., Okano H., Inazawa J., Hibi T., and Watanabe M. Increase of bone marrow-derived secretory lineage epithelial cells during regeneration in the human intestine. Gastroenterology 128 (2005) 1851-1867
16. Sander G.R., and Powell B.C. Expression of notch receptors and ligands in the adult gut. J. Histochem. Cytochem. 52 (2004) 509-516
17. Hiratochi M., Nagase H., Kuramochi Y., Koh C.S., Ohkawara T., and Nakayama K. The Delta intracellular domain mediates TGF-beta/Activin signaling through binding to Smads and has an important bi-directional function in the Notch-Delta signaling pathway. Nucleic Acids Res. 35 (2007) 912-922
18. Shimojo H., Ohtsuka T., and Kageyama R. Oscillations in notch signaling regulate maintenance of neural progenitors. Neuron 58 (2008) 52-64
19. Ridgway J., Zhang G., Wu Y., Stawicki S., Liang W.C., Chanthery Y., Kowalski J., Watts R.J., Callahan C., Kasman I., Singh M., Chien M., Tan C., Hongo J.A., de Sauvage F., Plowman G., and Yan M. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis. Nature 444 (2006) 1083-1087