Synthesis and biological evaluations of novel bendazac lysine analogues as potent anticataract agents

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 7, 2010, Pages 2115-2118

  Shen, Hong ^a   Gou, Shaohua ^a,b   Shen, Jianping ^c   Zhu, Yanqin ^c   Zhang, Yindi ^c   Chen, Xuetai ^a  

^a NANJING UNIVERSITY   (China)

^b SOUTHEAST UNIVERSITY   (China)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Anticataract agents; Aqueous solubility; Bendazac lysine analogues

Indexed keywords

ANTIOXIDANT; BENDAZAC LYSINE; FERROUS CHLORIDE; HYDROGEN PEROXIDE; PROTEIN; UNCLASSIFIED DRUG; WATER SOLVENT PROTEIN;

ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; IN VITRO STUDY; LENS; NONHUMAN; OXIDATIVE STRESS; SOLUBILITY;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; CATARACT; INDAZOLES; LENS, CRYSTALLINE; OXIDATIVE STRESS; RABBITS; RATS; SOLUBILITY;

EID: 77949491281     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.061     Document Type: Article

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28. + = 382.
29. - = 325.
30. 5), 7.05-7.80 (m, 11H, 9H of 2Ar and 2H of 2 imidazole), 8.27 (s, 2H of 2 imidazole).