Vagal control of mucociliary clearance in murine lungs: A study in a chronic preparation

Autonomic Neuroscience: Basic and Clinical

Volumn 154, Issue 1-2, 2010, Pages 74-78

  Bhashyam, Abhiram R ^a   Mogayzel Jr , Peter J ^a   Cleary, Jeffrey C ^a   Undem, Bradley J ^a   Kollarik, Marian ^a   Fox, James ^a   Laube, Beth L ^a  

^a DEPARTMENT OF PATHOLOGY   (United States)

Author keywords

Denervation; Mucociliary clearance; Murine model; Vagal control

Indexed keywords

CAPSAICIN; TECHNETIUM 99M;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; DENERVATION; GAMMA SCINTIGRAPHY; LUNG CLEARANCE; LUNG TRANSPLANTATION; MALE; MOUSE; MUCOCILIARY CLEARANCE; NERVE FIBER C; NOCICEPTION; NONHUMAN; OROPHARYNX; PAIN; PRIORITY JOURNAL; RADIOACTIVITY; VAGOTOMY; VAGUS NERVE STIMULATION;

ANIMALS; CAPSAICIN; DRUG ADMINISTRATION SCHEDULE; LUNG; MALE; MICE; MICE, INBRED C57BL; MUCOCILIARY CLEARANCE; RADIOPHARMACEUTICALS; RESPIRATORY ASPIRATION; RESPIRATORY SYSTEM; SENSORY SYSTEM AGENTS; TECHNETIUM TC 99M DIMERCAPTOSUCCINIC ACID; TIME FACTORS; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON; VAGOTOMY; VAGUS NERVE;

EID: 77949487564     PISSN: 15660702     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.autneu.2009.12.002     Document Type: Article

References (29)

1. Alton E.W.F.W., Khagani A., Taylor R.F.H., Logan-Sinclair R., Yacoub M., and Geddes D.M. Effect of heart-lung transplantation on airway potential difference in patients with and without cystic fibrosis. Eur. Respir. J. 4 (1991) 5-9
2. Anderson W.D. Thorax of Sheep and Man: an Anatomy Atlas (1971), Dillon, Minneapolis
3. Bennett W.D., Olivier K.N., Zeman K.L., Hohneker K.W., Boucher R.C., and Knowles M.R. Effect of uridine 5′-triphosphate plus amiloride on mucociliary clearance in adult cystic fibrosis. Am. J. Respir. Crit. Care Med. 153 (1996) 1796-1801
4. Borthwick D.W., West J.D., Keighren M.A., Flockhart J.H., Innes B.A., and Dorin J.R. Murine submucosal glands are clonally derived and show a cystic fibrosis gene-dependent distribution pattern. Am. J. Respir. Cell Mol. Biol. 20 (1999) 1181-1189
5. Donaldson S.H., Bennett W.D., Zeman K.L., Knowles M.R., Tarran R., and Boucher R.C. Mucus clearance and lung function in cystic fibrosis with hypertonic saline. N. Engl. J. Med. 354 (2006) 241-250
6. Eljamal M., Wong L.B., and Yeates D.B. Capsaicin-activated bronchial- and alveolar-initiated pathways regulating tracheal ciliary beat frequency. J. Appl. Physiol. 77 (1994) 1239-1245
7. Foster W.M., Walters D.M., Longphre M., Macri K., and Miller L.M. Methodology for the measurement of mucociliary function in the mouse by scintigraphy. J. Appl. Physiol. 90 (2001) 1111-1117
8. Hofmann W., and Asgharian B. The effect of lung structure on mucociliary clearance and particle retention in human and rat lungs. Toxicol. Sci. 73 (2003) 448-456
9. Ilowite J.S., Smaldone G.C., Perry R.J., Bennett W.D., and Foster W.M. Relationship between tracheobronchial particle clearance rates and sites of initial deposition in man. Arch. Environ. Health 44 (1989) 267-273
10. Kollarik M., Thai Dinh Q., Fischer A., and Undem B.J. Capsaicin-sensitive and -insensitive vagal bronchopulmonary C-fibres in the mouse. J. Physiol. 551 (2003) 869-879
11. Laube B.L., Auci R.M., Shields D.E., et al. Effect of rhDNase on airflow obstruction and mucociliary clearance in cystic fibrosis. Am. J. Respir. Crit. Care Med. 153 (1996) 752-760
12. Laube B.L., Karmazyn Y.J., Orens J.B., and Mogayzel P.J. Albuterol improves impaired mucociliary clearance after lung transplantation. J. Heart Lung Transplant. 26 (2007) 138-144
13. McDowell E.M., Barrett L.A., Glavin F., Harris C.C., and Trump B.F. The respiratory epithelium. I. Human bronchus. J. Natl. Cancer Inst. 61 (1978) 539-549
14. McGrath-Morrow S., Laube B., Tzou S.C., et al. IL-12 overexpression in mice as a model for Sjogren lung disease. Am. J. Physiol. 291 (2006) L837-L846
15. Mortensen J., Hansen A., Falk M., Nielsen I.K., and Groth S. Reduced effect of inhaled beta 2-adrenergic agonists on lung mucociliary clearance in patients with cystic fibrosis. Chest 103 (1993) 805-811
16. Oberdorster G., Cox C., and Gelein R. Intratracheal instillation versus intratracheal inhalation of tracer particles for measuring lung clearance function. Exp. Lung Res. 23 (1997) 17-34
17. Pack R.J., Al-Ugaily L.H., Morris G., and Widdicombe J.G. The distribution and structure of cells in the tracheal epithelium of the mouse. Cell Tissue Res. 208 (1980) 65-84
18. Pariente R. Therapeutic aspects of mucociliary clearance. Biomed. Pharmacother. 42 (1988) 521-524
19. Patrick G., and Stirling C. Measurement of mucociliary clearance from the trachea of conscious and anesthetized rats. J. Appl. Physiol. 42 (1977) 451-455
20. Paul A., Marelli D., Shennib H., et al. Mucociliary function in autotransplanted, allotransplanted, and sleeve resected lungs. J. Thorac. Cardiovasc. Surg. 98 (1989) 523-528
21. Plopper C.G., Hill L.H., and Mairassy A.T. Ultrastructure of the non-ciliated bronchiolar epithelial (Clara) cell of mammalian lung. III. A study of man with comparison of 15 mammalian species. Exp. Lung Res. 1 (1980) 171-180
22. Raabe O.G., Al-Bayati M.A., Teague S.V., and Rasolt A. Regional deposition of inhaled monodisperse coarse and fine aerosol particles in small laboratory animals. Ann. Occup. Hyg. 32 Suppl1 (1988) 53-63
23. Randell S.H., and Boucher R.C. Effective mucus clearance is essential for respiratory health. Am. J. Respir. Cell Mol. Biol. 35 (2006) 20-28
24. Robinson M., Regnis J.A., Bailey D.L., King M., Bautovich G.J., and Bye P.T. Effect of hypertonic saline, amiloride, and cough on mucociliary clearance in patients with cystic fibrosis. Am. J. Respir. Crit. Care Med. 153 (1996) 1503-1509
25. Smaldone G.C., Perry R., Bennett W.D., Messina M., Zwang J., and Ilowite J. Interpretation of 24 hr lung retention in studies of mucociliary clearance. J. Aerosol Med. 1 (1988) 11-20
26. Studer S.M., Levy R.D., McNeil K., and Orens J.B. Lung transplant outcomes: a review of survival, graft function, physiology, health-related quality of life and cost-effectiveness. Eur. Respir. J. 24 (2004) 674-685
27. Undem B.J., and Kollarik M. The role of vagal afferent nerves in chronic obstructive pulmonary disease. Proc. Am. Thorac. Soc. 2 (2005) 355-360
28. Undem B.J., Chuaychoo B., Lee M.-G., Weinreich D., Myers A.C., and Kollarik M. Subtypes of vagal afferent C-fibres in guinea-pig lungs. J. Physiol. 556 (2004) 905-917
29. Wolff R. Mucociliary function. In: Parent R.A. (Ed). Treatise on Pulmonary Toxicology, Volume I: Comparative Biology of the Normal Lung (1991), CRC Press, Boca Raton 659-680