Formation of parkin aggregates and enhanced PINK1 accumulation during the pathogenesis of Parkinson's disease

Biochemical and Biophysical Research Communications

Volumn 393, Issue 4, 2010, Pages 824-828

  Um, Ji Won ^a   Park, Hyun Jung ^b   Song, Jihwan ^c   Jeon, Iksoo ^c   Lee, Gwang ^b   Lee, Phil Hyu ^d   Chung, Kwang Chul ^a  

^a Yonsei University   (South Korea)

^b Ajou University School of Medicine   (South Korea)

^c CHA University   (South Korea)

^d Yonsei University College of Medicine   (South Korea)

Author keywords

Animal model; Lewy bodies; Parkin; Parkinson disease; PINK1; Toxin

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; OXIDOPAMINE; PARKIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PTEN INDUCED KINASE 1; ROTENONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CELL CULTURE; DISEASE MODEL; MALE; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; UPREGULATION;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; BRAIN; CELL LINE; DISEASE MODELS, ANIMAL; HUMANS; LEUPEPTINS; LEWY BODIES; MICE; OXIDOPAMINE; PARKINSON DISEASE; PROTEIN KINASES; RATS; SOLUBILITY; UBIQUITIN-PROTEIN LIGASES;

ANIMALIA; MUS; RATTUS;

EID: 77949486137     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.02.090     Document Type: Article

References (25)

1. Olanow C.W., and Tatton W.G. Etiology and pathogenesis of Parkinson's disease. Annu. Rev. Neurosci. 22 (1999) 123-144
2. Moore D.J., West A.B., Dawson V.L., and Dawson T.M. Molecular pathophysiology of Parkinson's disease. Annu. Rev. Neurosci. 28 (2005) 57-87
3. Thomas B., and Beal M.F. Parkinson's disease. Hum. Mol. Genet. 16 (2007) 183-194
4. Shimura H., Hattori N., Kubo S., Mizuno Y., Asakawa S., Minoshima S., Shimizu N., Iwai K., Chiba T., Tanaka K., and Suzuki T. Familial Parkinson disease gene product, parkin, is a ubiquitin-protein ligase. Nat. Genet. 25 (2000) 302-305
5. Silvestri L., Caputo V., Bellacchio E., Atorino L., Dallapiccola B., Valente E.M., and Casari G. Mitochondrial import and enzymatic activity of PINK1 mutants associated to recessive parkinsonism. Hum. Mol. Genet. 14 (2005) 3477-3492
6. Abou-Sleiman P.M., Muqit M.M., McDonald N.Q., Yang Y.X., Gandhi S., Healy D.G., Harvey K., Harvey R.J., Deas E., Bhatia K., Quinn N., Lees A., Latchman D.S., and Wood N.W. A heterozygous effect for PINK1 mutations in Parkinson's disease?. Ann. Neurol. 60 (2006) 414-419
7. Beilina A., Van Der Brug M., Ahmad R., Kesavapany S., Miller D.W., Petsko G.A., and Cookson M.R. Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability. Proc. Natl. Acad. Sci. USA 102 (2005) 5703-5708
8. Clark I.E., Dodson M.W., Jiang C., Cao J.H., Huh J.R., Seol J.H., Yoo S.J., Hay B.A., and Guo M. Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441 (2006) 1162-1166
9. Park J., Lee S.B., Lee S., Kim Y., Song S., Kim S., Bae E., Kim J., Shong M., Kim J.M., and Chung J. Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature 441 (2006) 1157-1161
10. Yang Y., Gehrke S., Imai Y., Huang Z., Ouyang Y., Wang J.W., Yang L., Beal M.F., Vogel H., and Lu B. Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin. Proc. Natl. Acad. Sci. USA 103 (2006) 10793-10798
11. Exner N., Treske B., Paquet D., Holmström K., Schiesling C., Gispert S., Carballo-Carbajal I., Berg D., Hoepken H.H., Gasser T., Krüger R., Winklhofer K.F., Vogel F., Reichert A.S., Auburger G., Kahle P.J., Schmid B., and Haass C. Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J. Neurosci. 27 (2007) 12413-12418
12. Deng H., Dodson M.W., Huang H., and Guo M. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila. Proc. Natl. Acad. Sci. USA 105 (2008) 14503-14508
13. Poole A.C., Thomas R.E., Andrews L.A., McBride H.M., Whitworth A.J., and Pallanck L.J. The PINK1/Parkin pathway regulates mitochondrial morphology. Proc. Natl. Acad. Sci. USA 105 (2008) 1638-1643
14. Park J., Lee G., and Chung J. The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process. Biochem. Biophys. Res. Commun. 378 (2009) 518-523
15. Kim Y., Park J., Kim S., Song S., Kwon S.K., Lee S.H., Kitada T., Kim J.M., and Chung J. PINK1 controls mitochondrial localization of Parkin through direct phosphorylation. Biochem. Biophys. Res. Commun. 377 (2008) 975-980
16. Um J.W., Stichel-Gunkel C., Lübbert H., Lee G., and Chung K.C. Molecular interaction between parkin and PINK1 in mammalian neuronal cells. Mol. Cell. Neurosci. 40 (2009) 421-432
17. Xiong H., Wang D., Chen L., Choo Y.S., Ma H., Tang C., Xia K., Jiang W., Ronai Z., Zhuang X., and Zhang Z. Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J. Clin. Invest. 119 (2009) 650-660
18. Shiba K., Arai T., Sato S., Kubo S.I., Ohba Y., Mizuno Y., and Hattori N. Parkin stabilizes PINK1 through direct interaction. Biochem. Biophys. Res. Commun. 383 (2009) 331-335
19. Wang C., Ko H.S., Thomas B., Tsang F., Chew K.C., Tay S.P., Ho M.W., Lim T.M., Soong T.W., Pletnikova O., Troncoso J., Dawson V.L., Dawson T.M., and Lim K.L. Stress-induced alterations in parkin solubility promote parkin aggregation and compromise parkin's protective function. Hum. Mol. Genet. 14 (2005) 3885-3897
20. LaVoie M.J., Ostaszewski B.L., Weihofen A., Schlossmacher M.G., and Selkoe D.J. Dopamine covalently modifies and functionally inactivates parkin. Nat. Med. 11 (2005) 1214-1221
21. Wong E.S., Tan J.M., Wang C., Zhang Z., Tay S.P., Zaiden N., Ko H.S., Dawson V.L., Dawson T.M., and Lim K.L. Relative sensitivity of parkin and other cysteine-containing enzymes to stress-induced solubility alterations. J. Biol. Chem. 282 (2007) 12310-12318
22. LaVoie M.J., Cortese G.P., Ostaszewski B.L., and Schlossmacher M.G. The effects of oxidative stress on parkin and other E3 ligases. J. Neurochem. 103 (2007) 2354-2368
23. Yao D., Gu Z., Nakamura T., Shi Z.Q., Ma Y., Gaston B., Palmer L.A., Rockenstein E.M., Zhang Z., Masliah E., Uehara T., and Lipton S.A. Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. Proc. Natl. Acad. Sci. USA 101 (2004) 10810-10814
24. Sun F., Kanthasamy A., Anantharam V., and Kanthasamy A.G. Environmental neurotoxic chemicals-induced ubiquitin proteasome system dysfunction in the pathogenesis and progression of Parkinson's disease. Pharmacol. Ther. 114 (2007) 327-344
25. Tang B., Xiong H., Sun P., Zhang Y., Wang D., Hu Z., Zhu Z., Ma H., Pan Q., Xia J.H., Xia K., and Zhang Z. Association of PINK1 and DJ-1 confers digenic inheritance of early-onset Parkinson's disease. Hum. Mol. Genet. 15 (2006) 1816-1825