Reduction of hERG inhibitory activity in the 4-piperidinyl urea series of H3 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 7, 2010, Pages 2359-2364

  Berlin, Michael ^a   Lee, Yoon Joo ^a   Boyce, Christopher W ^a   Wang, Yi ^a   Aslanian, Robert ^a   McCormick, Kevin D ^a   Sorota, Steve ^a   Williams, Shirley M ^a   West Jr , Robert E ^a   Korfmacher, Walter ^a  

^a Chemical Research   (United States)

Author keywords

H3 antagonists; hERG inhibition; Histamine; N Aryl N benzyl N piperidinyl urea

Indexed keywords

HISTAMINE H3 RECEPTOR ANTAGONIST; POTASSIUM CHANNEL HERG; UREA DERIVATIVE;

AREA UNDER THE CURVE; ARTICLE; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG HALF LIFE; DRUG SCREENING; DRUG STRUCTURE; ENZYME INHIBITION; LIPOPHILICITY; RECEPTOR AFFINITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; ETHER-A-GO-GO POTASSIUM CHANNELS; HISTAMINE ANTAGONISTS; HUMANS; PIPERIDINES; RATS; RECEPTORS, HISTAMINE H3; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 77949486075     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.121     Document Type: Article

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