Differential Expression of Hepatic Fibrosis Mediators in Sick and Spontaneously Recovered Mice with Experimental Biliary Atresia1

Journal of Surgical Research

Volumn 159, Issue 2, 2010, Pages 611-617

  Nadler, Evan P ^a   Li, Xiaolu ^a   Onyedika, Emeka ^a   Greco, M Alba ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

biliary atresia; metalloproteinases; plasminogen activator inhibitor; tissue inhibitor of matrix metalloproteinases

Indexed keywords

BILIRUBIN; CD147 ANTIGEN; CONNECTIVE TISSUE GROWTH FACTOR; FIBRILLAR COLLAGEN; FIBRONECTIN; GELATINASE A; GELATINASE B; GLUCOSE; MATRILYSIN; MESSENGER RNA; PLASMINOGEN ACTIVATOR INHIBITOR 1; SIMIAN ROTAVIRUS VACCINE; SODIUM CHLORIDE; TISSUE INHIBITOR OF METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TISSUE INHIBITOR OF METALLOPROTEINASE 3; TISSUE INHIBITOR OF METALLOPROTEINASE 4; TRANSCRIPTION FACTOR SNAIL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE DUCT ATRESIA; CONVALESCENCE; DISEASE COURSE; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRACELLULAR MATRIX; FISHER EXACT TEST; FLUORESCENCE; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER; LIVER FIBROSIS; LIVER PARENCHYMA; MEDIATOR RELEASE; MOUSE; NEWBORN; NEWBORN JAUNDICE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANK SUM TEST; REAL TIME POLYMERASE CHAIN REACTION; RESUSCITATION; STATISTICAL SIGNIFICANCE; STUDENT T TEST; SURVIVAL RATE; WEIGHT GAIN;

ANIMALS; ANIMALS, NEWBORN; BILIARY ATRESIA; ENZYME-LINKED IMMUNOSORBENT ASSAY; EUKARYOTIC INITIATION FACTORS; GENE EXPRESSION REGULATION; LIVER CIRRHOSIS; MICE; MICE, INBRED BALB C; PLASMINOGEN ACTIVATOR INHIBITOR 1; REMISSION, SPONTANEOUS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; ROTAVIRUS; ROTAVIRUS INFECTIONS; TISSUE INHIBITOR OF METALLOPROTEINASE-1;

EID: 77949485702     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2009.10.038     Document Type: Article

References (21)

1. Ramm G.A., Nair V.G., Bridle K.R., et al. Contribution of hepatic parenchymal and nonparenchymal cells to hepatic fibrogenesis in biliary atresia. Am J Pathol 153 (1998) 527
2. Hsieh C.S., Chuang J.H., Huang C.C., et al. Evaluation of matrix metalloproteinases and their endogenous tissue inhibitors in biliary atresia-associated liver fibrosis. J Pediatr Surg 40 (2005) 1568
3. Nadler E.P., Patterson D., Violette S., et al. Integrin alphavbeta6 and mediators of extracellular matrix deposition are upregulated in experimental biliary atresia. J Surg Res (2008 Jun 20) [Epub ahead of print]
4. Petersen C., Biermanns D., Kuske M., et al. New aspects in a murine model for extrahepatic biliary atresia. J Pediatr Surg 32 (1997) 1190
5. Georges P.C., Hui J.J., Gombos Z., et al. Increased stiffness of the rat liver precedes matrix deposition: implications for fibrosis. Am J Physiol Gastrointest Liver Physiol 293 (2007) G1147
6. Lee S.Y., Chuang J.H., Huang C.C., et al. Identification of transforming growth factors actively transcribed during the progress of liver fibrosis in biliary atresia. J Pediatr Surg 39 (2004) 702
7. Czech-Schmidt G., Verhagen W., Szavay P., et al. Immunological gap in the infectious animal model for biliary atresia. J Surg Res 101 (2001) 62
8. Shivakumar P., Campbell K.M., Sabla G.E., et al. Obstruction of extrahepatic bile ducts by lymphocytes is regulated by IFN- γ in experimental biliary atresia. J Clin Invest 114 (2004) 322
9. Shteyer E., Ramm G.A., Xu C., et al. Outcome after portoenterostomy in biliary atresia: pivotal role of degree of liver fibrosis and intensity of stellate cell activation. J Pediatr Gastroenterol Nutr 42 (2006) 93
10. Shinkai M., Ohhama Y., Take H., et al. Long-term outcome of children with biliary atresia who were not transplanted after the Kasai operation: >20-year experience at a children's hospital. J Pediatr Gastroenterol Nutr 48 (2009) 443
11. McKiernan P.J., Baker A.J., Lloyd C., et al. British pediatric surveillance unit study of biliary atresia: Outcome at 13 years. J Pediatr Gastroenterol Nutr 48 (2009) 78
12. Harada K., Sato Y., Ikeda H., et al. Epithelial-mesenchymal transition induced by biliary innate immunity contributes to the sclerosing cholangiopathy of biliary atresia. J Pathol 217 (2009) 654
13. Ramm G.A., Shepherd R.W., Hoskins A.C., et al. Fibrogenesis in pediatric cholestatic liver disease: Role of taurocholate and hepatocyte-derived monocyte chemotaxis protein-1 in hepatic stellate cell recruitment. Hepatology 49 (2009) 533
14. Qi Z., Atsuchi N., Ooshima A., et al. Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat. Proc Natl Acad Sci U S A 96 (1999) 2345
15. George J., Roulot D., Koteliansky V.E., et al. In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: A potential new therapy for hepatic fibrosis. Proc Natl Acad Sci U S A 96 (1999) 12719
16. Wang B., Dolinski B.M., Kikuchi N., et al. Role of alphavbeta6 integrin in acute biliary fibrosis. Hepatology 46 (2007) 1404
17. Elias G.J., Ioannis M., Theodora P., et al. Circulating tissue inhibitor of matrix metalloproteinase-4 (TIMP-4) in systemic sclerosis patients with elevated pulmonary arterial pressure. Mediators Inflamm 2008 (2008) 164134 [Epub 2009 Jan 25]
18. Buxton P.G., Bitar M., Gellynck K., et al. Dense collagen matrix accelerates osteogenic differentiation and rescues the apoptotic response to MMP inhibition. Bone 43 (2008) 377 [Epub 2008 Apr 15]
19. Wang H., Vohra B.P., Zhang Y., et al. Transcriptional profiling after bile duct ligation identifies PAI-1 as a contributor to cholestatic injury in mice. Hepatology 42 (2005) 1099
20. Murphy G., and Nagase H. Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: Destruction or repair?. Nat Clin Prac Rheumatol 4 (2008) 128
21. Milner J.M., and Cawston T.E. Matrix metalloproteinase knockout studies and the potential use of matrix metalloproteinase inhibitors in the rheumatic diseases. Curr Drug Targets Inflamm Allergy 4 (2005) 363