Report of a successful treatment of pulmonary Cunninghamella bertholletiae infection with liposomal amphotericin and posaconazole in a child with GvHD and review of the literature

Journal of Pediatric Hematology/Oncology

Volumn 32, Issue 2, 2010, Pages 85-87

  Garbino, Jorge ^a   Myers, Catherine ^a   Ambrosioni, Juan ^a   Gumy Pause, Fabienne ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Antifungal treatment; Cunninghamella bertholletiae; GVHD; Posaconazole; Zygomycosis

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; BUSULFAN; CORTICOSTEROID; COTRIMOXAZOLE; CYCLOPHOSPHAMIDE; CYCLOSPORIN; POSACONAZOLE; PREDNISONE; TACROLIMUS; VORICONAZOLE;

ACUTE GRANULOCYTIC LEUKEMIA; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; CASE REPORT; CHILD; CUNNINGHAMELLA BERTHOLLETIAE; DISEASE SEVERITY; DRUG MEGADOSE; DRUG SUBSTITUTION; DRUG WITHDRAWAL; FEMALE; GASTROINTESTINAL DISEASE; GRAFT VERSUS HOST REACTION; HISTOPATHOLOGY; HUMAN; IMMUNOCOMPROMISED PATIENT; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY FAILURE; LUNG MYCOSIS; MUCORMYCOSIS; PRIORITY JOURNAL; QUALITY OF LIFE; REMISSION; SCHOOL CHILD; SKIN DISEASE; TREATMENT OUTCOME;

AMPHOTERICIN B; BONE MARROW TRANSPLANTATION; CHILD; CUNNINGHAMELLA; DRUG THERAPY, COMBINATION; FEMALE; GRAFT VS HOST DISEASE; HUMANS; LUNG DISEASES, FUNGAL; MUCORMYCOSIS; TRIAZOLES;

EID: 77949463105     PISSN: 10774114     EISSN: 15363678     Source Type: Journal    
DOI: 10.1097/MPH.0b013e3181c2bdce     Document Type: Article

References (16)

1. Nucci M, Marr KA. Emerging fungal diseases. Clin Infect Dis. 2005;41:521-526.
2. Koyama N, Nagata M, Hagiwara K, et al. Cunninghamella bertholletiae infection in a bone marrow transplant patient: amphotericin lung penetration, MIC determinations, and review of the literature. Respirology. 2008;13:309-311.
3. Kontoyiannis DP, Wessel VC, Bodey GP, et al. Zygomycosis in the 1990s in a tertiary-care cancer center. Clin Infect Dis. 2000;30:851-856.
4. Kauffman CA. Zygomycosis: reemergence of an old pathogen. Clin Infect Dis. 2004;39:588-590.
5. Antachopoulos C, Walsh TJ. New agents for invasive mycoses in children. Curr Opin Pediatr. 2005;17:78-87.
6. Sun QN, Fothergill AW, McCarthy DI, et al. In vitro activities of posaconazole, itraconazole, voriconazole, amphotericin B, and fluconazole against 37 clinical isolates of zygomycetes. Antimicrob Agents Chemother. 2002;46:1581-1582.
7. Dannaoui E, Meletiadis J, Mouton JW, et al. In vitro susceptibilities of zygomycetes to conventional and new antifungals. J Antimicrob Chemother. 2003;51:45-52.
8. Sun QN, Najvar LK, Bocanegra R, et al. In vivo activity of posaconazole against Mucor spp. in an immunosuppressed- mouse model. Antimicrob Agent Chemother. 2002;46:2310-2312.
9. Gilman AL, Serrano A, Skelley J, et al. Successful treatment of pulmonary zygomycosis with posaconazole in a recipient of a haploidentical donor stem cell transplant. Pediatr Blood Cancer. 2006;47:959-963.
10. Lüer S, Berger S, Diepold M, et al. Treatment of intestinal and hepatic mucormycosis in an immunocompromized child. Pediatr Blood Cancer. 2009;52:872-874.
11. Bibashi E, Sidi V, Kotsiou M, et al. Pulmonary Zygomycosis caused by Cunninghamella bertholletiae in a child with acute lymphoblastic leukemia. Hippokratia. 2008;12:43-45.
12. Lassalle S, Butori C, Hofman V, et al. Pneumonia caused by Cunninghamella bertholletiae in a patient with acute lymphoblastic leukemia. Ann Pathol. 2007;27:141-144.
13. Segal B, Barnhart LA, Anderson VL, et al. Posaconazole as salvage therapy in patients with chronic granulomatous disease and invasive filamentous fungal infection. Clin Inf Dis. 2005;40:1684-1688.
14. Van Burik JA, Hare RS, Solomon HF, et al. Posaconazole is effective as salvage therapy in zygomycosis: a retrospective summary of 91 cases. Clin Infect Dis. 2006;42:61-65.
15. Cornely OA, Maertens J, Winston DJ, et al. Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia. N Engl J Med. 2007;356:348-359.
16. Ullmann AJ, Lipton JH, Vesole DH, et al. Posaconazole or fluconazole for prophylaxis in severe graft-versus-host disease. N Engl J Med. 2007;356:335-347.