-
1
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2
-
Slamon DJ, Leyland-Jones B, Shak S, Fuchs H, Paton V, Bajamonde A, et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N Engl J Med 2001;344:783-792
-
(2001)
N Engl J Med
, vol.344
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
Fuchs, H.4
Paton, V.5
Bajamonde, A.6
-
2
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Druker BJ, Sawyers CL, Kantarjian H, Resta DJ, Reese SF, Ford JM, et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med 2001;344:1038-1042
-
(2001)
N Engl J Med
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
Resta, D.J.4
Reese, S.F.5
Ford, J.M.6
-
3
-
-
0034306450
-
Specificity and mechanism of action of some commonly used protein kinase inhibitors
-
Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 2000;351:95-105.
-
(2000)
Biochem J
, vol.351
, pp. 95-105
-
-
Davies, S.P.1
Reddy, H.2
Caivano, M.3
Cohen, P.4
-
4
-
-
19744365702
-
A small molecule-kinase interaction map for clinical kinase inhibitors
-
Fabian MA, Biggs WH 3rd, Treiber DK, Atteridge CE, Azimioara MD, Benedetti MG, et al. A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol 2005;23:329-336
-
(2005)
Nat Biotechnol
, vol.23
, pp. 329-336
-
-
Fabian, M.A.1
Biggs III, W.H.2
Treiber, D.K.3
Atteridge, C.E.4
Azimioara, M.D.5
Benedetti, M.G.6
-
5
-
-
0041318841
-
Structural basis for p38′ MAP kinase quinazolinone and pyridolpyrimidine inhibitor specificity
-
Fitzgerald CE, Patel SB, Becker JW, Cameron PM, Zaller D, Pikounis VB, et al. Structural basis for p38′ MAP kinase quinazolinone and pyridolpyrimidine inhibitor specificity. Nat Struct Biol 2003;10:764-769
-
(2003)
Nat Struct Biol
, vol.10
, pp. 764-769
-
-
Fitzgerald, C.E.1
Patel, S.B.2
Becker, J.W.3
Cameron, P.M.4
Zaller, D.5
Pikounis, V.B.6
-
6
-
-
0032802629
-
Increased glycogen synthase kinase-3 activity in diabetes- and obesityprone C57BL/6J mice
-
Eldar-Finkelman H, Schreyer SA, Shinohara MM, LeBoeuf RC, Krebs EG. Increased glycogen synthase kinase-3 activity in diabetes- and obesityprone C57BL/6J mice. Diabetes 1999;48:1662-1666
-
(1999)
Diabetes
, vol.48
, pp. 1662-1666
-
-
Eldar-Finkelman, H.1
Schreyer, S.A.2
Shinohara, M.M.3
Leboeuf, R.C.4
Krebs, E.G.5
-
7
-
-
0028892186
-
Amyloid β peptide induces cytoplasmic accumulation of amyloid protein precursor via tau protein kinase I/glycogen synthase kinase-3 ?in rat hippocampal neurons
-
Takashima A, Yamaguchi H, Noguchi K, Michel G, Ishiguro K, Sato K, et al. Amyloid β peptide induces cytoplasmic accumulation of amyloid protein precursor via tau protein kinase I/glycogen synthase kinase-3 βin rat hippocampal neurons. Neurosci Lett 1995;198:83-86
-
(1995)
Neurosci Lett
, vol.198
, pp. 83-86
-
-
Takashima, A.1
Yamaguchi, H.2
Noguchi, K.3
Michel, G.4
Ishiguro, K.5
Sato, K.6
-
8
-
-
0036273020
-
Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation
-
Martinez A, Castro A, Dorronsoro I, Alonso M. Glycogen synthase kinase 3 (GSK-3) inhibitors as new promising drugs for diabetes, neurodegeneration, cancer, and inflammation. Med Res Rev 2002;22:373-384
-
(2002)
Med Res Rev
, vol.22
, pp. 373-384
-
-
Martinez, A.1
Castro, A.2
Dorronsoro, I.3
Alonso, M.4
-
9
-
-
16844374033
-
Glycogen synthase kinase-3β participates in nuclear factor kB-mediated gene transcription and cell survival in pancreatic cancer cells
-
Ougolkov AV, Fernandez-Zapico ME, Savoy DN, Urrutia RA, Billadeau DD. Glycogen synthase kinase-3β participates in nuclear factor kB-mediated gene transcription and cell survival in pancreatic cancer cells. Cancer Res 2005;65:2076-2081.
-
(2005)
Cancer Res
, vol.65
, pp. 2076-2081
-
-
Ougolkov, A.V.1
Fernandez-Zapico, M.E.2
Savoy, D.N.3
Urrutia, R.A.4
Billadeau, D.D.5
-
10
-
-
0025286104
-
Molecular cloning and expression of glycogen synthase kinase-3/factor A
-
Woodgett JR. Molecular cloning and expression of glycogen synthase kinase-3/factor A. EMBO J 1990;9:2431-2438
-
(1990)
EMBO J
, vol.9
, pp. 2431-2438
-
-
Woodgett, J.R.1
-
11
-
-
33845873363
-
Development and validation of a modular, extensible docking program: DOCK 5
-
Moustakas DT, Lang PT, Pegg S, Pettersen E, Kuntz ID, Brooijmans N, et al. Development and validation of a modular, extensible docking program: DOCK 5. J Comput Aided Mol Des 2006;20:601-619
-
(2006)
J Comput Aided Mol des
, vol.20
, pp. 601-619
-
-
Moustakas, D.T.1
Lang, P.T.2
Pegg, S.3
Pettersen, E.4
Kuntz, I.D.5
Brooijmans, N.6
-
12
-
-
0141645621
-
Structural characterization of the GSK-3β active site using selective and non-selective ATP-mimetic inhibitors
-
Bertrand JA, Thieffine S, Vulpetti A, Cristiani C, Valsasina B, Knapp S, et al. Structural characterization of the GSK-3β active site using selective and non-selective ATP-mimetic inhibitors. J Mol Biol 2003;333:393-407.
-
(2003)
J Mol Biol
, vol.333
, pp. 393-407
-
-
Bertrand, J.A.1
Thieffine, S.2
Vulpetti, A.3
Cristiani, C.4
Valsasina, B.5
Knapp, S.6
-
13
-
-
0033954256
-
The protein data bank
-
Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, et al. The Protein Data Bank. Nucleic Acids Res 2000;28:235-242
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 235-242
-
-
Berman, H.M.1
Westbrook, J.2
Feng, Z.3
Gilliland, G.4
Bhat, T.N.5
Weissig, H.6
-
14
-
-
77949472761
-
-
http://www.accelrys.com/products/
-
-
-
-
15
-
-
0023769808
-
Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase-trimethoprim, a drug-receptor system
-
Dauber-Osguthorpe P, Roberts VA, Osguthorpe DJ, Wolff J, Genest M, Hagler AT. Structure and energetics of ligand binding to proteins: Escherichia coli dihydrofolate reductase-trimethoprim, a drug-receptor system. Proteins Struct Func Gen 1988;4:31-47.
-
(1988)
Proteins Struct Func Gen
, vol.4
, pp. 31-47
-
-
Dauber-Osguthorpe, P.1
Roberts, V.A.2
Osguthorpe, D.J.3
Wolff, J.4
Genest, M.5
Hagler, A.T.6
-
16
-
-
0346875916
-
GSK-3-selective inhibitors derived from Tyrian purple indirubins
-
Meijer L, Skaltsounis AL, Magiatis P, Polychronopoulos P, Knockaert M, Leost M, et al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol 2003;10:1255-1266
-
(2003)
Chem Biol
, vol.10
, pp. 1255-1266
-
-
Meijer, L.1
Skaltsounis, A.L.2
Magiatis, P.3
Polychronopoulos, P.4
Knockaert, M.5
Leost, M.6
-
17
-
-
41849132449
-
Pharmacophore modeling, quantitative structure-activity relationship analysis, and in silico screening reveal potent glycogen synthase kinase-3β inhibitory activities for cimetidine, hydroxychloroquine, and gemifloxacin
-
Taha MO, Bustanji Y, Al-Ghussein MA, Mohammad M, Zalloum H, Al-Masri IM, et al. Pharmacophore modeling, quantitative structure-activity relationship analysis, and in silico screening reveal potent glycogen synthase kinase-3β inhibitory activities for cimetidine, hydroxychloroquine, and gemifloxacin. J Med Chem 2008;51:2062-2077
-
(2008)
J Med Chem
, vol.51
, pp. 2062-2077
-
-
Taha, M.O.1
Bustanji, Y.2
Al-Ghussein, M.A.3
Mohammad, M.4
Zalloum, H.5
Al-Masri, I.M.6
-
19
-
-
2442562756
-
Pairwise GB/SA scoring function for structurebased drug design
-
Liu HY, Kuntz ID, Zou X. Pairwise GB/SA scoring function for structurebased drug design. J Phys Chem B 2004;108: 5453-5462
-
(2004)
J Phys Chem B
, vol.108
, pp. 5453-5462
-
-
Liu, H.Y.1
Kuntz, I.D.2
Zou, X.3
-
20
-
-
0036022960
-
Further development and validation of empirical scoring functions for structure-based binding affinity prediction
-
Wang R, Lai L, Wang S. Further development and validation of empirical scoring functions for structure-based binding affinity prediction. J Comput Aided Mol Des 2002;16:11-26.
-
(2002)
J Comput Aided Mol des
, vol.16
, pp. 11-26
-
-
Wang, R.1
Lai, L.2
Wang, S.3
-
21
-
-
0034645763
-
Knowledge-based scoring function to predict protein-ligand interactions
-
Gohlke H, Hendlich M, Klebe G. Knowledge-based scoring function to predict protein-ligand interactions. J Mol Biol 2000;295:337-356
-
(2000)
J Mol Biol
, vol.295
, pp. 337-356
-
-
Gohlke, H.1
Hendlich, M.2
Klebe, G.3
-
22
-
-
26444588137
-
DrugScore(CSD)-knowledge-based scoring function derived from small molecule crystal data with superior recognition rate of near-native ligand poses and better affinity prediction
-
Velec HF, Gohlke H, Klebe G. DrugScore(CSD)-knowledge-based scoring function derived from small molecule crystal data with superior recognition rate of near-native ligand poses and better affinity prediction. J Med Chem 2005;48:6296-6303
-
(2005)
J Med Chem
, vol.48
, pp. 6296-6303
-
-
Velec, H.F.1
Gohlke, H.2
Klebe, G.3
-
23
-
-
0037013143
-
The conformational plasticity of protein kinases
-
Huse M, Kuriyan J. The conformational plasticity of protein kinases. Cell 2002;109:275-282
-
(2002)
Cell
, vol.109
, pp. 275-282
-
-
Huse, M.1
Kuriyan, J.2
-
24
-
-
1442351132
-
Protein flexibility in ligand docking and virtual screening to protein kinases
-
Cavasotto CN, Abagyan RA. Protein flexibility in ligand docking and virtual screening to protein kinases. J Mol Biol 2004;337:209-225
-
(2004)
J Mol Biol
, vol.337
, pp. 209-225
-
-
Cavasotto, C.N.1
Abagyan, R.A.2
-
25
-
-
49449112578
-
Active site pressurization: A new tool for structure-guided drug design and other studies of protein flexibility
-
Withers IM, Mazanetz MP, Wang H, Fischer PM, Laughton CA. Active site pressurization: a new tool for structure-guided drug design and other studies of protein flexibility. J Chem Inf Model 2008;48:1448-1454
-
(2008)
J Chem Inf Model
, vol.48
, pp. 1448-1454
-
-
Withers, I.M.1
Mazanetz, M.P.2
Wang, H.3
Fischer, P.M.4
Laughton, C.A.5
-
26
-
-
3242884966
-
High-throughput docking as a source of novel drug leads
-
Alvarez JC. High-throughput docking as a source of novel drug leads. Curr Opin Chem Biol 2004;8:365-370
-
(2004)
Curr Opin Chem Biol
, vol.8
, pp. 365-370
-
-
Alvarez, J.C.1
|