Combination of romiplostim and rituximab: Effective therapy of severe immune thrombocytopenia

European Journal of Haematology

Volumn 84, Issue 4, 2010, Pages 362-364

  Pohlen, Michele ^a   Sargin, Bülent ^a   Zicholl, Stefan ^a   Bisping, Guido ^a   Müller Tidow, Carsten ^a   Berdel, Wolfgang E ^a   Mesters, Rolf ^a   Koschmieder, Steffen ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BLOOD CLOTTING FACTOR 13; DEXAMETHASONE; IMMUNOGLOBULIN; IMMUNOGLOBULIN D; MONOCLONAL ANTIBODY; PREDNISOLONE; RITUXIMAB; ROMIPLOSTIM; THROMBOCYTE ANTIGEN; TRANEXAMIC ACID;

ADULT; ANTIBODY TITER; AUTOLOGOUS STEM CELL TRANSPLANTATION; AUTOTRANSPLANTATION; BONE MARROW; BRAIN HEMORRHAGE; CASE REPORT; DRUG DOSE INCREASE; DRUG WITHDRAWAL; FEMALE; GRAFT FAILURE; HEADACHE; HODGKIN DISEASE; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; LABORATORY TEST; LETTER; MEGAKARYOCYTE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; SPLENECTOMY; THROMBOCYTE COUNT; THROMBOCYTE TRANSFUSION; THROMBOCYTOPENIA; THROMBOCYTOPOIESIS;

ADULT; ANTIBODIES, MONOCLONAL; AUTOANTIBODIES; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; IMMUNOLOGIC FACTORS; MIDDLE AGED; PLATELET COUNT; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RECEPTORS, FC; RECOMBINANT FUSION PROTEINS; REMISSION INDUCTION; THROMBOPOIETIN;

EID: 77949447606     PISSN: 09024441     EISSN: 16000609     Source Type: Journal    
DOI: 10.1111/j.1600-0609.2009.01406.x     Document Type: Letter

References (8)

1. Rodeghiero F, Stasi R, Gernsheimer T, et al. Standardization of terminology, definitions and outcome criteria in immune thrombocytopenic purpura of adults and children: report from an international working group. Blood 2009;113:2386-93.
2. Ballem PJ, Segal GM, Stratton JR, Gernsheimer T, Adamson JW, Slichter SJ. Mechanisms of thrombocytopenia in chronic autoimmune thrombocytopenic purpura. Evidence of both impaired platelet production and increased platelet clearance. J Clin Invest 1987;80:33-40.
3. Bussel JB, Kuter DJ, George JN, et al. AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP. N Engl J Med 2006;355:1672-81.
4. Kuter DJ, Bussel JB, Lyons RM, et al. Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial. Lancet 2008;371:395-403.
5. Bussel JB, Provan D, Shamsi T, et al. Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial. Lancet 2009;373:641-8.
6. Bussel JB, Kuter DJ, Pullarkat V, Lyons RM, Guo M, Nichol JL. Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP. Blood 2009;113:2161-71.
7. Cooper N, Stasi R, Cunningham-Rundles S, Feuerstein MA, Leonard JP, Amadori S, Bussel JB. The efficacy and safety of B-cell depletion with anti-CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpura. Br J Haematol 2004;125:232-9.
8. Boruchov DM, Gururangan S, Driscoll MC, Bussel JB. Multiagent induction and maintenance therapy for patients with refractory immune thrombocytopenic purpura (ITP). Blood 2007;110:3526-31.