Formulation and evaluation of controlled release antibiotic biodegradable implants for post operative site delivery

Acta Pharmaceutica

Volumn 60, Issue 1, 2010, Pages 111-117

  Mathur, Vijay ^a   Mudnaik, Rajesh ^a   Barde, Laxmikant ^a   Roy, Arghya ^a   Shivhare, Umesh ^a   Bhusari, Kishore ^a  

^a Nagar Yuwak Shikshan Sanstha   (India)

Author keywords

Biodegradable antibiotic implants; Controlled drug release; Erosion enhancers; Glyceryl monostearate; Site delivery

Indexed keywords

CIPROFLOXACIN; GLYCEROL; GLYCEROL ACETOACETATE; MACROGOL; POLYSORBATE 80; ANTIINFECTIVE AGENT; DELAYED RELEASE FORMULATION;

AGAR DIFFUSION; ARTICLE; BIODEGRADABLE IMPLANT; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG IMPLANT; DRUG RELEASE; DRUG SCREENING; DRUG SOLUBILITY; DRUG STABILITY; HYDROPHOBICITY; IN VITRO STUDY; INJECTION SITE; MATRIX TABLET; POSTOPERATIVE CARE; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE FORMULATION; TABLET COMPRESSION; ADMINISTRATION AND DOSAGE; CHEMISTRY; COMPARATIVE STUDY; DELAYED RELEASE FORMULATION; MEDICINAL CHEMISTRY; MICROBIOLOGY; PHARMACOKINETICS; POSTOPERATIVE COMPLICATIONS; PROCEDURES; SYNTHESIS;

ABSORBABLE IMPLANTS; ANTI-BACTERIAL AGENTS; CHEMISTRY, PHARMACEUTICAL; CIPROFLOXACIN; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; POSTOPERATIVE COMPLICATIONS;

EID: 77949441789     PISSN: 13300075     EISSN: None     Source Type: Journal    
DOI: 10.2478/v10007-010-0005-z     Document Type: Article

References (12)

1. C. Schmidt, R. Wenz, B. Nies and F. Moll, Antibiotic in vivo/in vitro release, histocompatibility and biodegradation of gentamycin implants on lactic acid polymers and copolymers, J. Control. Rel. 37 (1995) 83-94; DOI: 10.1016/0168-3659(95)00067-1.
2. M. E. A. Mamun, H. A. Khan, I. Dewan and R. U. Jalil, In vitro study on tamsulosin release kinetics from biodegradable PLGA in situ implants, Pak. J. Pharm. Sci. 22 (2009) 360-367.
3. M. Ramchandani and D. Robinson, In vitro and in vivo release of ciprofloxacin from PLGA 50:50 implants, J. Control. Rel. 54 (1998) 167-175; DOI: 10.1016/s0168-3659(97)00113-2.
4. P. Y. Wang, C. X. Song, H. F. Sun, H. L. Shi and R. W. Shi, A biodegradable long-term contraceptive implant, Eng. Med. Biol. Soc. 6 (1998) 2901-2904; DOI: 10.1109/IEMS.1998.746093.
5. http://www.surgistrategies.com/hotnews/baxter-agreement-with-innocall- implant.html; access date January 11, 2010.
6. C. Guse, S. Koennings, F. Kreye, F. Siepmann, A. Goepferich and J. Siepmann, Drug release from lipid-based implants: Elucidation of the underlying mass transport mechanisms, Int. J. Pharm. 314 (2006) 137-144; DOI: 10.1016/j.i.jpharm.2005.08.030.
7. J. C. Shah and S. Allababidi, Glyceryl Monostearate Based Biodegradable Implants for Site Specific Delivery of Drugs, U.S. Pat. 5,891,456, 6 Apr 1999;
8. Chem. Abstr. 130 (1999) 271997f.
9. United States Pharmacopoeia 30, National Formulary 25, United State Pharmacopeial Convection, Rockville 2007, pp. 1759-1760.
10. S. Allababidi and J. Shah, Kinetic and mechanism of release from glyceryl monostearate based implants: Evaluation of release in a gel simulating in vivo implantations, J. Pharm. Sci. 87 (1998) 169-172; DOI: 10.1021/js9703986.
11. ICH Harmonised Tripartite Guideline, Stability Testing of New Drug Substances and Products, Q1A (R2), Current Step 4 version, 6 February 2003.
12. P. Costa and J. M. S. Lobo, Modeling and comparison of dissolution profiles, Eur. J. Pharm. Sci. 13 (2001) 123-133.