Signs of an in situ inflammatory reaction in scars of human American tegumentary leishmaniasis

Parasite Immunology

Volumn 32, Issue 4, 2010, Pages 285-295

  Morgado, F N ^a,b   Schubach, A ^b   Vasconcellos, E ^b   Azeredo Coutinho, R B ^b   Valete Rosalino, C M ^b,c   Quintella, L P ^b   Santos, G ^b   Salgueiro, M ^b   Palmeiro, M R ^a,b   Conceicao Silva F ^a  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b Funda??o Oswaldo Cruz   (Brazil)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

ATL; Cellular immune response; Immunohistochemistry; In situ; Scars

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; FAS ANTIGEN; INDUCIBLE NITRIC OXIDE SYNTHASE; KI 67 ANTIGEN; PROTEIN BCL 2;

ADULT; AGED; AMERICAN TEGUMENTARY LEISHMANIASIS; ARTICLE; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEISHMANIASIS; LYMPHOCYTE; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCAR; SKIN BLOOD VESSEL; SKIN DEFECT; SKIN FIBROSIS; SKIN GLAND;

ADOLESCENT; ADULT; AGED; ANIMALS; CICATRIX; FEMALE; HUMANS; IMMUNITY, CELLULAR; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LEISHMANIASIS, CUTANEOUS; MALE; MICROSCOPY; MIDDLE AGED; TIME FACTORS; YOUNG ADULT;

EID: 77949439314     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/j.1365-3024.2009.01188.x     Document Type: Article

References (40)

1. Vieira-GonÅalves R, Pirmez C, Jorge ME, et al. Clinical features of cutaneous and disseminated cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis in Paraty, Rio de Janeiro. Int J Dermatol 2008; 47: 926-932.
2. Oliveira-Neto MP, Mattos M, Souza CS, Fernandes O & Pirmez C. Leishmaniasis recidiva cutis in New World cutaneous leishmaniasis. Int J Dermatol 1998; 37: 846-849.
3. Kupper TS & Fuhlbrigge RC. Immune surveillance in the skin: mechanisms and clinical consequences. Nat Rev Immunol 2004; 4: 211-222.
4. Streilein JW. Skin-associated lymphoid tissues (SALT): origins and functions. J Invest Dermatol 1983; 80: 12s-16s.
5. Bos JD & Kapsenberg ML. The skin immune system: progress in cutaneous biology. Immunol Today 1993; 14: 75-78.
6. Greenhalgh DG. The role of apoptosis in wound healing. Int J Biochem Cell Biol 1998; 30: 1019-1030.
7. Hunt TK, Hopf H & Hussain Z. Physiology of wound healing. Adv Skin Wound Care 2000; 13: 6-11.
8. Henry G & Garner WL. Inflammatory mediators in wound healing. Surg Clin North Am 2003; 83: 483-507.
9. Stenger S, Donhauser N, Thüring H, Röllinghoff M & Bogdan C. Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase. J Exp Med 1996; 183: 1501-1514.
10. Conceição-Silva F, Hahne M, Schröter M, Louis J & Tschopp J. The resolution of lesions induced by Leishmania major in mice requires a functional Fas (APO-1, CD95) pathway of cytotoxicity. Eur J Immunol 1998; 28: 237-245.
11. Schubach A, Marzochi MC, Cuzzi-Maya T, et al. Cutaneous scars in American tegumentary leishmaniasis patients: a site of Leishmania (Viannia) braziliensis persistence and viability eleven years after antimonial therapy and clinical cure. Am J Trop Med Hyg 1998; 58: 824-827.
12. Bogdan C & Röllinghoff M. How do protozoan parasites survive inside macrophages? Parasitol Today (Regul Ed) 1999; 15: 22-28.
13. Bogdan C, Donhauser N, Döring R, Röllinghoff M, Diefenbach A & Rittig MG. Fibroblasts as host cells in latent leishmaniosis. J Exp Med 2000; 191: 2121-2130.
14. Schubach A, Cuzzi-Maya T, Oliveira AV, et al. Leishmanial antigens in the diagnosis of active lesions and ancient scars of American tegumentary leishmaniasis patients. Mem Inst Oswaldo Cruz 2001; 96: 987-996.
15. Mendonça MG, de Brito MEF, Rodrigues EHG, Bandeira V, Jardim ML & Abath FGC. Persistence of leishmania parasites in scars after clinical cure of American cutaneous leishmaniasis: is there a sterile cure? J Infect Dis 2004; 189: 1018-1023.
16. Morgado FN, Schubach A, Rosalino CMV, et al. Is the in situ inflammatory reaction an important tool to understand the cellular immune response in American tegumentary leishmaniasis? Br J Dermatol 2008; 158: 50-58.
17. Convit J, Ulrich M, Fernández CT, et al. The clinical and immunological spectrum of American cutaneous leishmaniasis. Trans R Soc Trop Med Hyg 1993; 87: 444-448.
18. Da-Cruz AM, Conceição-Silva F, Bertho AL & Coutinho SG. Leishmania-reactive CD4+ and CD8+ T cells associated with cure of human cutaneous leishmaniasis. Infect Immun 1994; 62: 2614-2618.
19. Amato VS, de Andrade HF & Duarte MIS. Mucosal leishmaniasis: in situ characterization of the host inflammatory response, before and after treatment. Acta Trop 2003; 85: 39-49.
20. Gaze ST, Dutra WO, Lessa M, et al. Mucosal leishmaniasis patients display an activated inflammatory T-cell phenotype associated with a nonbalanced monocyte population. Scand J Immunol 2006; 63: 70-78.
21. Meneghin A & Hogaboam CM. Infectious disease, the innate immune response, and fibrosis. J Clin Invest 2007; 117: 530-538.
22. Madeira MF, Schubach A, Schubach TMP, et al. Mixed infection with Leishmania (Viannia) braziliensis and Leishmania (Leishmania) chagasi in a naturally infected dog from Rio de Janeiro, Brazil. Trans R Soc Trop Med Hyg 2006; 100: 442-445.
23. Tuon FF, Duarte MIS & Amato VS. A quantitative and morphometric study of mast cells in cutaneous leishmaniasis. Parasite Immunol 2008; 30: 641-645.
24. Da-Cruz AM, Bittar R, Mattos M, et al. T-cell-mediated immune responses in patients with cutaneous or mucosal leishmaniasis: long-term evaluation after therapy. Clin Diagn Lab Immunol 2002; 9: 251-256.
25. Da-Cruz AM, Bertho AL, Oliveira-Neto MP & Coutinho SG. Flow cytometric analysis of cellular infiltrate from American tegumentary leishmaniasis lesions. Br J Dermatol 2005; 153: 537-543.
26. Bos JD, Zonneveld I, Das PK, Krieg SR, van der Loos CM & Kapsenberg ML. The skin immune system (SIS): distribution and immunophenotype of lymphocyte subpopulations in normal human skin. J Invest Dermatol 1987; 88: 569-573.
27. Fujiwara N & Kobayashi K. Macrophages in inflammation. Curr Drug Targets Inflamm Allergy 2005; 4: 281-286.
28. Murray PJ. Defining the requirements for immunological control of mycobacterial infections. Trends Microbiol 1999; 7: 366-372.
29. Lüder CG, Gross U & Lopes MF. Intracellular protozoan parasites and apoptosis: diverse strategies to modulate parasitehost interactions. Trends Parasitol 2001; 17: 480-486.
30. Lüder CGK & Gross U. Apoptosis and its modulation during infection with Toxoplasma gondii: molecular mechanisms and role in pathogenesis. Curr Top Microbiol Immunol 2005; 289: 219-237.
31. Uzonna JE & Bretscher PA. Anti-IL-4 antibody therapy causes regression of chronic lesions caused by medium-dose Leishmania major infection in BALB?c mice. Eur J Immunol 2001; 31: 3175-3184.
32. Osorio Y, Melby PC, Pirmez C, Chandrasekar B, Guarín N & Travi BL. The site of cutaneous infection influences the immunological response and clinical outcome of hamsters infected with Leishmania panamensis. Parasite Immunol 2003; 25: 139-148.
33. Gomes-Silva A, de Cássia Bittar R, Dos Santos Nogueira R, et al. Can interferon-gamma and interleukin-10 balance be associated with severity of human Leishmania (Viannia) braziliensis infection? Clin Exp Immunol 2007; 149: 440-444.
34. Duarte MIS, de Andrade HF, Takamura CFH, Sesso A & Tuon FF. TGF-beta and mesenchymal hepatic involvement after visceral leishmaniasis. Parasitol Res 2009; 104: 1129-1136.
35. de Oliveira MP, Lima MCR, Calheiros AS, et al. Leishmania (Viannia) braziliensis: human mast cell line activation induced by logarithmic and stationary promastigote derived-lysates. Exp Parasitol 2005; 109: 72-79.
36. Belkaid Y, Piccirillo CA, Mendez S, Shevach EM & Sacks DL. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 2002; 420: 502-507.
37. van der Meide WF, Peekel I, van Thiel PPAM, et al. Treatment assessment by monitoring parasite load in skin biopsies from patients with cutaneous leishmaniasis, using quantitative nucleic acid sequence-based amplification. Clin Exp Dermatol 2008; 33: 394-399.
38. Kubar J, Marty P, Leliévre A, et al. Visceral leishmaniosis in HIV-positive patients: primary infection, reactivation and latent infection. Impact of the CD4+ T-lymphocyte counts. AIDS 1998; 12: 2147-2153.
39. Czechowicz RT, Millard TP, Smith HR, Ashton RE, Lucas SB & Hay RJ. Reactivation of cutaneous leishmaniasis after surgery. Br J Dermatol 1999; 141: 1113-1116.
40. Orteu CH, Poulter LW, Rustin MH, Sabin CA, Salmon M & Akbar AN. The role of apoptosis in the resolution of T cellmediated cutaneous inflammation. J Immunol 1998; 161: 1619-1629.