메뉴 건너뛰기




Volumn 220, Issue 2, 2010, Pages 115-120

High micronucleus frequency in peripheral blood lymphocytes of untreated cancer patients irrespective of gender, smoking and cancer sites

Author keywords

Chromosomal instability; Different cancer site; Micronuclei; Peripheral blood lymphocytes; Untreated cancer patients

Indexed keywords

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER LOCALIZATION; CANCER PATIENT; CHROMOSOME; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINESIS; FEMALE; GENETIC DAMAGE; GROUPS BY AGE; HUMAN; MALE; MICRONUCLEUS; PERIPHERAL LYMPHOCYTE; PHARYNX CANCER; SEX DIFFERENCE; SMOKING HABIT; UTERUS CANCER;

EID: 77949425973     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.220.115     Document Type: Article
Times cited : (33)

References (32)
  • 1
    • 0024404824 scopus 로고
    • Micronuclei: Origins, applications and methodologies-a workshop sponsored by the Health and Safety Executive held in Manchester, May 23-25, 1988
    • Arlett, C., Ashby, J., Fielder, R.J. & Scott, D. (1989) Micronuclei: origins, applications and methodologies-a workshop sponsored by the Health and Safety Executive held in Manchester, May 23-25, 1988. Mutagenesis, 4, 482-485.
    • (1989) Mutagenesis , vol.4 , pp. 482-485
    • Arlett, C.1    Ashby, J.2    Fielder, R.J.3    Scott, D.4
  • 2
    • 0035144198 scopus 로고    scopus 로고
    • Bonassi, S., Fenech, M., Lando, C., Lin, Y.P., Ceppi, M., Chang, W.P., Holland, N., Kirsh-Volders, M., Zeiger, E., Ban, S., Barale, R., Bigatti, M.P., Bolognesi, C., Jia, C., Di Giorgio, M., Ferguson, L.R., Fucic, A., Lima, O.G., Hrelia, P., Krishnaja, A.P., Lee, T.K., Migliore, L., Mikhalevich, L., Mirkova, E., Mosesso, P., Müller, W.U., Odagiri, Y. , Scarffi, M.R., Szabova, E., Vorobtsova, I., Vral, A. & Zjino, A. (2001) Human Micro-Nucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria and host factors on the frequency of micronuclei. Environ. Mol. Mutagen., 37, 31-45.
    • Bonassi, S., Fenech, M., Lando, C., Lin, Y.P., Ceppi, M., Chang, W.P., Holland, N., Kirsh-Volders, M., Zeiger, E., Ban, S., Barale, R., Bigatti, M.P., Bolognesi, C., Jia, C., Di Giorgio, M., Ferguson, L.R., Fucic, A., Lima, O.G., Hrelia, P., Krishnaja, A.P., Lee, T.K., Migliore, L., Mikhalevich, L., Mirkova, E., Mosesso, P., Müller, W.U., Odagiri, Y. , Scarffi, M.R., Szabova, E., Vorobtsova, I., Vral, A. & Zjino, A. (2001) Human Micro-Nucleus project: international database comparison for results with the cytokinesis-block micronucleus assay in human lymphocytes: I. Effect of laboratory protocol, scoring criteria and host factors on the frequency of micronuclei. Environ. Mol. Mutagen., 37, 31-45.
  • 3
    • 0037339166 scopus 로고    scopus 로고
    • Bonassi, S., Neri, M., Lando, C., Ceppi, M., Lin, Y., Chang, W.P., Holland, N., Kirsch-Volders, M., Zeiger, E. & Fenech, M.; the HUMN collaborative group. (2003) Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project. Mutat. Res., 543, 155-166.
    • Bonassi, S., Neri, M., Lando, C., Ceppi, M., Lin, Y., Chang, W.P., Holland, N., Kirsch-Volders, M., Zeiger, E. & Fenech, M.; the HUMN collaborative group. (2003) Effect of smoking habit on the frequency of micronuclei in human lymphocytes: results from the Human MicroNucleus project. Mutat. Res., 543, 155-166.
  • 6
    • 1842611683 scopus 로고    scopus 로고
    • Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells
    • Duesberg, P., Fabarius, A. & Hehlmann, R. (2004) Aneuploidy, the primary cause of the multilateral genomic instability of neoplastic and preneoplastic cells. IUBMB Life, 56, 65-81.
    • (2004) IUBMB Life , vol.56 , pp. 65-81
    • Duesberg, P.1    Fabarius, A.2    Hehlmann, R.3
  • 8
    • 1842407141 scopus 로고    scopus 로고
    • Comparison between micronucleated lymphocyte rates observed in healthy subjects and cancer patients
    • Duffaund, F., Orsière, T., Villani, P., Pelissier, A.L., Volot, F., Favre, R. & Botta, A. (1997) Comparison between micronucleated lymphocyte rates observed in healthy subjects and cancer patients. Mutagenesis, 12, 227-231.
    • (1997) Mutagenesis , vol.12 , pp. 227-231
    • Duffaund, F.1    Orsière, T.2    Villani, P.3    Pelissier, A.L.4    Volot, F.5    Favre, R.6    Botta, A.7
  • 9
    • 0027497435 scopus 로고
    • The cytokinesis-block micronucleus technique: A detailed description of the method and its application to genotoxicity studies in human populations
    • Fenech, M. (1993) The cytokinesis-block micronucleus technique: a detailed description of the method and its application to genotoxicity studies in human populations. Mutat. Res., 285, 35-44.
    • (1993) Mutat. Res , vol.285 , pp. 35-44
    • Fenech, M.1
  • 10
    • 0034693730 scopus 로고    scopus 로고
    • The in vitro micronucleus technique
    • Fenech, M. (2000) The in vitro micronucleus technique. Mutat. Res., 455, 81-95.
    • (2000) Mutat. Res , vol.455 , pp. 81-95
    • Fenech, M.1
  • 11
    • 33747335092 scopus 로고    scopus 로고
    • Cytokinesis-block micronucleus assay evolves into a "cytome" assay of chromosomal instability, mitotic dysfunction and cell death
    • Fenech, M. (2006) Cytokinesis-block micronucleus assay evolves into a "cytome" assay of chromosomal instability, mitotic dysfunction and cell death. Mutat. Res., 600, 58-66.
    • (2006) Mutat. Res , vol.600 , pp. 58-66
    • Fenech, M.1
  • 12
    • 0032785259 scopus 로고    scopus 로고
    • The Human Micro Nucleus Project-An international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans
    • Fenech, M., Holland, N., Chang, W.P., Zeiger, E. & Bonassi, S. (1999) The Human Micro Nucleus Project-An international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans. Mutat. Res., 428, 271-283.
    • (1999) Mutat. Res , vol.428 , pp. 271-283
    • Fenech, M.1    Holland, N.2    Chang, W.P.3    Zeiger, E.4    Bonassi, S.5
  • 13
    • 38148999467 scopus 로고    scopus 로고
    • Basal level micronucleus frequency in stimulated lymphocytes of untreated patients with leukemia
    • Hamurcu, Z., Dönmez-Altuntas, H. & Patiroglu, T. (2008) Basal level micronucleus frequency in stimulated lymphocytes of untreated patients with leukemia. Cancer Genet. Cytogenet., 180, 140-144.
    • (2008) Cancer Genet. Cytogenet , vol.180 , pp. 140-144
    • Hamurcu, Z.1    Dönmez-Altuntas, H.2    Patiroglu, T.3
  • 14
    • 0029902171 scopus 로고    scopus 로고
    • Primary vs. secondary neoplasia-associated chromosomal abnormalities-balanced rearrangements vs. genomic imbalances?
    • Johansson, B., Mertens, F. & Mitelman, F. (1996) Primary vs. secondary neoplasia-associated chromosomal abnormalities-balanced rearrangements vs. genomic imbalances? Genes Chromosomes Cancer, 16, 155-163.
    • (1996) Genes Chromosomes Cancer , vol.16 , pp. 155-163
    • Johansson, B.1    Mertens, F.2    Mitelman, F.3
  • 15
    • 0037170665 scopus 로고    scopus 로고
    • Micronuclei in cervical smears and peripheral blood lymphocytes from women with and without cervical uterine cancer
    • Leal-Garza, C.H., Cerda-Flores, R.M., Leal-Elizondo, E. & Cortés-Gutiérrez, E.I. (2002) Micronuclei in cervical smears and peripheral blood lymphocytes from women with and without cervical uterine cancer. Mutat. Res., 515, 57-62.
    • (2002) Mutat. Res , vol.515 , pp. 57-62
    • Leal-Garza, C.H.1    Cerda-Flores, R.M.2    Leal-Elizondo, E.3    Cortés-Gutiérrez, E.I.4
  • 16
    • 27744565789 scopus 로고    scopus 로고
    • Chromosomal alterations cause the high rates and wide ranges of drug resistance in cancer cells
    • Li, R., Hehlmann, R., Sachs, R. & Duesberg, P. (2005) Chromosomal alterations cause the high rates and wide ranges of drug resistance in cancer cells. Cancer Genet. Cytogenet., 163, 44-56.
    • (2005) Cancer Genet. Cytogenet , vol.163 , pp. 44-56
    • Li, R.1    Hehlmann, R.2    Sachs, R.3    Duesberg, P.4
  • 18
    • 33847698160 scopus 로고    scopus 로고
    • Investigating the genetic instability in the peripheral lymphocytes of 36 untreated lung cancer patients with comet assay and micronucleus assay
    • Lou, J., He, J., Zheng, W., Jin, L., Chen, Z., Chen, S., Lin, Y. & Xu, S. (2007) Investigating the genetic instability in the peripheral lymphocytes of 36 untreated lung cancer patients with comet assay and micronucleus assay. Mutat. Res., 617, 104-110.
    • (2007) Mutat. Res , vol.617 , pp. 104-110
    • Lou, J.1    He, J.2    Zheng, W.3    Jin, L.4    Chen, Z.5    Chen, S.6    Lin, Y.7    Xu, S.8
  • 19
    • 33751119273 scopus 로고    scopus 로고
    • Chromosomal changes: Induction, detection methods and applicability in human biomnitoring
    • Mateuca, R., Lombaert, N., Aka, P.V., Decordier, I. & Kirsch-Volders, M. (2006) Chromosomal changes: induction, detection methods and applicability in human biomnitoring. Biochimie, 88, 1515-1531.
    • (2006) Biochimie , vol.88 , pp. 1515-1531
    • Mateuca, R.1    Lombaert, N.2    Aka, P.V.3    Decordier, I.4    Kirsch-Volders, M.5
  • 21
    • 39249083917 scopus 로고    scopus 로고
    • Validation of micronuclei frequency in peripheral blood lymphocytes as early cancer risk biomarker in a nested case-control study
    • Murgia, E., Ballardin, M., Bonassi, S., Rossi, A.M. & Barale, R. (2008) Validation of micronuclei frequency in peripheral blood lymphocytes as early cancer risk biomarker in a nested case-control study. Mutat. Res., 639, 27-34.
    • (2008) Mutat. Res , vol.639 , pp. 27-34
    • Murgia, E.1    Ballardin, M.2    Bonassi, S.3    Rossi, A.M.4    Barale, R.5
  • 22
    • 0038393167 scopus 로고    scopus 로고
    • What do human micronuclei contain?
    • Norppa, H. & Falck, G.C. (2003) What do human micronuclei contain? Mutagenesis, 18, 221-233.
    • (2003) Mutagenesis , vol.18 , pp. 221-233
    • Norppa, H.1    Falck, G.C.2
  • 23
    • 4644276792 scopus 로고    scopus 로고
    • Chromosomal rearrangement as the basis for human tumourigenesis
    • Radford, I.R. (2004) Chromosomal rearrangement as the basis for human tumourigenesis. Int. J. Radiat. Biol., 80, 543-557.
    • (2004) Int. J. Radiat. Biol , vol.80 , pp. 543-557
    • Radford, I.R.1
  • 24
    • 0027254069 scopus 로고
    • How many mutations are required for tumorigenesis? Implications from human cancer data
    • Renan, M.J. (1993) How many mutations are required for tumorigenesis? Implications from human cancer data. Mol. Carcinog., 7, 139-146.
    • (1993) Mol. Carcinog , vol.7 , pp. 139-146
    • Renan, M.J.1
  • 26
    • 0034069125 scopus 로고    scopus 로고
    • Cytogenetic monitoring of hospital workers occupationally exposed to ionizing radiation using the micronucleus centromere assay
    • Thierens, H., Vral, A., Morthier, R., Aousalah, B. & De Ridder, L. (2000) Cytogenetic monitoring of hospital workers occupationally exposed to ionizing radiation using the micronucleus centromere assay. Mutagenesis, 15, 245-249.
    • (2000) Mutagenesis , vol.15 , pp. 245-249
    • Thierens, H.1    Vral, A.2    Morthier, R.3    Aousalah, B.4    De Ridder, L.5
  • 27
    • 0036001288 scopus 로고    scopus 로고
    • Assessment of genotoxic effects related to chronic low dose level exposure to ionizing radiations using biomarkers for DNA damage and repair
    • Touil, N., Aka, P.V., Buchet, J.P., Thierens, H. & Kirsch-Volders, M. (2002) Assessment of genotoxic effects related to chronic low dose level exposure to ionizing radiations using biomarkers for DNA damage and repair. Mutagenesis, 17, 223-232.
    • (2002) Mutagenesis , vol.17 , pp. 223-232
    • Touil, N.1    Aka, P.V.2    Buchet, J.P.3    Thierens, H.4    Kirsch-Volders, M.5
  • 29
    • 0024344681 scopus 로고
    • Increased numbers of spontaneous micronuclei in blood lymphocytes and cultures fibroblasts of individuals with familial cutaneous malignant melanoma
    • Weichenthal, M., Roser, M., Ehlert, U., Frenzer, S., Breitbart, E. & Rüdiger, H.W. (1989) Increased numbers of spontaneous micronuclei in blood lymphocytes and cultures fibroblasts of individuals with familial cutaneous malignant melanoma. J. Cancer Res. Clin. Oncol., 115, 264-268.
    • (1989) J. Cancer Res. Clin. Oncol , vol.115 , pp. 264-268
    • Weichenthal, M.1    Roser, M.2    Ehlert, U.3    Frenzer, S.4    Breitbart, E.5    Rüdiger, H.W.6
  • 30
    • 27744590127 scopus 로고    scopus 로고
    • Chromosomal abnormalities associated with neck nodal metastasis in nasopharyngeal carcinoma
    • Yan, W., Song, L., Wei, W., Li, A., Liu, J. & Fang, Y. (2005) Chromosomal abnormalities associated with neck nodal metastasis in nasopharyngeal carcinoma. Tumour Biol., 26, 306-312.
    • (2005) Tumour Biol , vol.26 , pp. 306-312
    • Yan, W.1    Song, L.2    Wei, W.3    Li, A.4    Liu, J.5    Fang, Y.6
  • 31
    • 33745713553 scopus 로고    scopus 로고
    • Micronucleus frequency in peripheral blood lymphocytes and exfoliated buccal cells of untreated cancer patients
    • Yildirim, I.H., Yesilada, E. & Yologlu, S. (2006) Micronucleus frequency in peripheral blood lymphocytes and exfoliated buccal cells of untreated cancer patients. Genetika, 42, 705-710.
    • (2006) Genetika , vol.42 , pp. 705-710
    • Yildirim, I.H.1    Yesilada, E.2    Yologlu, S.3
  • 32
    • 33748082699 scopus 로고    scopus 로고
    • Effects of benzopyrene-7,8-diol-9,10-epoxide (BPDE) in vitro and of maternal smoking in vivo on micronuclei frequencies in fetal cord blood
    • Zalacain, M., Sierrasesumaga, L., Larrannaga, C. & Patinno-Garcia, A. (2006) Effects of benzopyrene-7,8-diol-9,10-epoxide (BPDE) in vitro and of maternal smoking in vivo on micronuclei frequencies in fetal cord blood. Pediatr. Res., 60, 180-184.
    • (2006) Pediatr. Res , vol.60 , pp. 180-184
    • Zalacain, M.1    Sierrasesumaga, L.2    Larrannaga, C.3    Patinno-Garcia, A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.