NUP98-HMGB3: A novel oncogenic fusion

Leukemia

Volumn 24, Issue 3, 2010, Pages 654-658

  Petit, A ^a,b,d   Ragu, C ^a,b   Della Valle, V ^a,b   Mozziconacci, M J ^c   Lafage Pochitaloff, M ^c   Soler, G ^a,b   Schluth, C ^a,b,e   Radford, I ^a,b   Ottolenghi, C ^a,b   Bernard, O A ^a,b   Penard Lacronique, V ^a,b   Romana, S P ^a,b  

^a HÔPITAL NECKER ENFANTS MALADES   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c Hô Pital Timone Enfants   (France)

^d ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^e HOSPICES CIVILS DE LYON   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HIGH MOBILITY GROUP B3 PROTEIN; HYBRID PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN; NUCLEOPORIN 98;

ACUTE MYELOBLASTIC LEUKEMIA; AMINO ACID SEQUENCE; ANEMIA; CHROMOSOME TRANSLOCATION; CODON; CYTOMETRY; DOWN REGULATION; DYSPNEA; EXON; FLUORESCENCE ACTIVATED CELL SORTING; FLUORESCENCE IN SITU HYBRIDIZATION; GENE CLUSTER; GENE EXPRESSION REGULATION; GENE MAPPING; GENE OVEREXPRESSION; GENE REARRANGEMENT; GENETIC ASSOCIATION; HUMAN; LETTER; LEUKOCYTOSIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PALLOR; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA BINDING; PROTEIN MOTIF; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS; SPLENOMEGALY; SURVIVAL TIME; THROMBOCYTOPENIA; UPREGULATION;

EID: 77949425444     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2009.241     Document Type: Letter

References (18)

1. Romana SP, Radford-Weiss I, Ben Abdelali R, Schluth C, Petit A, Dastugue N, et al. NUP98 rearrangements in hematopoietic malignancies: a study of the Groupe Francophone de Cytogene-tique Hematologique. Leukemia 2006; 20: 696-706.
2. Moore MA, Chung KY, Plasilova M, Schuringa JJ, Shieh JH, Zhou P, et al. NUP98 dysregulation in myeloid leukemogenesis. Ann NY Acad Sci 2007; 1106: 114-142.
3. Kasper LH, Brindle PK, Schnabel CA, Pritchard CE, Cleary ML, van Deursen JM. CREB binding protein interacts with nucleoporin-specific FG repeats that activate transcription and mediate NUP98-HOXA9 oncogenicity. Mol Cell Biol 1999; 19: 764-776.
4. Wang GG, Cai L, Pasillas MP, Kamps MP. NUP98-NSD1 links H3K36 methylation to Hox-A gene activation and leukaemo-genesis. Nat Cell Biol 2007; 9: 804-812.
5. Wang GG, Song J, Wang Z, Dormann HL, Casadio F, Li H, et al. Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature 2009; 459: 847-851.
6. Travers AA. Priming the nucleosome: a role for HMGB proteins? EMBO Rep 2003; 4: 131-136.
7. Nemeth MJ, Curtis DJ, Kirby MR, Garrett-Beal LJ, Seidel NE, Cline AP, et al. Hmgb3: an HMG-box family member expressed in primitive hematopoietic cells that inhibits myeloid and B-cell differentiation. Blood 2003; 102: 1298-1306.
8. Nemeth MJ, Kirby MR, Bodine DM. Hmgb3 regulates the balance between hematopoietic stem cell self-renewal and differentiation. Proc Natl Acad Sci USA 2006; 103: 13783-13788.
9. Somervaille TC, Matheny CJ, Spencer GJ, Iwasaki M, Rinn JL, Witten DM, et al. Hierarchical maintenance of MLL myeloid leukemia stem cells employs a transcriptional program shared with embryonic rather than adult stem cells. Cell Stem Cell 2009; 4: 129-140.
10. Su X, Drabkin H, Clappier E, Morgado E, Busson M, Romana SP, et al. Transforming potential of the T-cell acute lymphoblastic leukemia-associated homeobox genes HOXA13, TLX1, and TLX3. Genes Chromosomes Cancer 2006; 45: 846-855.
11. Kroon E, Thorsteinsdottir U, Mayotte N, Nakamura T, Sauvageau G. NUP98-HOXA9 expression in hemopoietic stem cells induces chronic and acute myeloid leukemias in mice. EMBO J 2001; 20: 350-361.
12. Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, et al. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood 2002; 100: 238-245.
13. Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature 2000; 404: 193-197.
14. Cozzio A, Passegue E, Ayton PM, Karsunky H, Cleary ML, Weissman IL. Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors. Genes Dev 2003; 17: 3029-3035.
15. Krivtsov AV, Armstrong SA. MLL translocations, histone modifications and leukaemia stem-cell development. Nat Rev Cancer 2007; 7: 823-833.
16. Palmqvist L, Pineault N, Wasslavik C, Humphries RK. Candidate genes for expansion and transformation of hematopoietic stem cells by NUP98-HOX fusion genes. PLoS ONE 2007; 2: e768.
17. Hirose K, Abramovich C, Argiropoulos B, Humphries RK. Leukemogenic properties of NUP98-PMX1 are linked to NUP98 and homeodomain sequence functions but not to binding properties of PMX1 to serum response factor. Oncogene 2008; 27: 6056-6067.
18. Jankovic D, Gorello P, Liu T, Ehret S, La Starza R, Desjobert C, et al. Leukemogenic mechanisms and targets of a NUP98/HHEX fusion in acute myeloid leukemia. Blood 2008; 111: 5672-5682.