메뉴 건너뛰기




Volumn 192, Issue 6, 2010, Pages 1479-1486

ExsD inhibits expression of the Pseudomonas aeruginosa type III secretion system by disrupting ExsA self-association and DNA binding activity

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; PROTEIN EXSA; PROTEIN EXSC; PROTEIN EXSD; PROTEIN EXSE; UNCLASSIFIED DRUG;

EID: 77949411171     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.01457-09     Document Type: Article
Times cited : (39)

References (37)
  • 1
    • 61449116896 scopus 로고    scopus 로고
    • Structural evidence suggests that antiactivator ExsD from Pseudomonas aeruginosa is a DNA binding protein
    • Bernhards, R. C., X. Jing, N. J. Vogelaar, H. Robinson, and F. D. Schubot. 2009. Structural evidence suggests that antiactivator ExsD from Pseudomonas aeruginosa is a DNA binding protein. Protein Sci. 18:503-513.
    • (2009) Protein Sci , vol.18 , pp. 503-513
    • Bernhards, R.C.1    Jing, X.2    Vogelaar, N.J.3    Robinson, H.4    Schubot, F.D.5
  • 2
    • 41749108855 scopus 로고    scopus 로고
    • Characterization of ExsA and of ExsA-dependent promoters required for expression of the Pseudomonas aeruginosa type III secretion system
    • Brutinel, E. D., C. A. Vakulskas, K. M. Brady, and T. L. Yahr. 2008. Characterization of ExsA and of ExsA-dependent promoters required for expression of the Pseudomonas aeruginosa type III secretion system. Mol. Microbiol. 68:657-671.
    • (2008) Mol. Microbiol , vol.68 , pp. 657-671
    • Brutinel, E.D.1    Vakulskas, C.A.2    Brady, K.M.3    Yahr, T.L.4
  • 3
    • 67549138763 scopus 로고    scopus 로고
    • Functional domains of ExsA, the transcriptional activator of the Pseudomonas aeruginosa type III secretion system
    • Brutinel, E. D., C. A. Vakulskas, and T. L. Yahr. 2009. Functional domains of ExsA, the transcriptional activator of the Pseudomonas aeruginosa type III secretion system. J. Bacteriol. 191:3811-3821.
    • (2009) J. Bacteriol , vol.191 , pp. 3811-3821
    • Brutinel, E.D.1    Vakulskas, C.A.2    Yahr, T.L.3
  • 4
    • 42049102380 scopus 로고    scopus 로고
    • Control of gene expression by type III secretory activity
    • Brutinel, E. D., and T. L. Yahr. 2008. Control of gene expression by type III secretory activity. Curr. Opin. Microbiol. 11:128-133.
    • (2008) Curr. Opin. Microbiol , vol.11 , pp. 128-133
    • Brutinel, E.D.1    Yahr, T.L.2
  • 5
    • 0035035809 scopus 로고    scopus 로고
    • TrlR, a defective TraR-like protein of Agrobacterium tumefaciens, blocks TraR function in vitro by forming inactive TrlR:TraR dimers
    • Chai, Y., J. Zhu, and S. C. Winans. 2001. TrlR, a defective TraR-like protein of Agrobacterium tumefaciens, blocks TraR function in vitro by forming inactive TrlR:TraR dimers. Mol. Microbiol. 40:414-421.
    • (2001) Mol. Microbiol , vol.40 , pp. 414-421
    • Chai, Y.1    Zhu, J.2    Winans, S.C.3
  • 8
    • 0036440482 scopus 로고    scopus 로고
    • Use of LexA-based system to identify protein-protein interactions in vivo
    • Daines, D. A., M. Granger-Schnarr, M. Dimitrova, and R. P. Silver. 2002. Use of LexA-based system to identify protein-protein interactions in vivo. Methods Enzymol. 358:153-161.
    • (2002) Methods Enzymol , vol.358 , pp. 153-161
    • Daines, D.A.1    Granger-Schnarr, M.2    Dimitrova, M.3    Silver, R.P.4
  • 9
    • 3142549041 scopus 로고    scopus 로고
    • A novel anti-anti-activator mechanism regulates expression of the Pseudomonas aeruginosa type III secretion system
    • Dasgupta, N., G. L. Lykken, M. C. Wolfgang, and T. L. Yahr. 2004. A novel anti-anti-activator mechanism regulates expression of the Pseudomonas aeruginosa type III secretion system. Mol. Microbiol. 53:297-308.
    • (2004) Mol. Microbiol , vol.53 , pp. 297-308
    • Dasgupta, N.1    Lykken, G.L.2    Wolfgang, M.C.3    Yahr, T.L.4
  • 10
    • 0036786814 scopus 로고    scopus 로고
    • Growing repertoire of AraC/XylS activators
    • Egan, S. M. 2002. Growing repertoire of AraC/XylS activators. J. Bacteriol. 184:5529-5532.
    • (2002) J. Bacteriol , vol.184 , pp. 5529-5532
    • Egan, S.M.1
  • 11
    • 0025948303 scopus 로고
    • Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa
    • Frank, D. W., and B. H. Iglewski. 1991. Cloning and sequence analysis of a trans-regulatory locus required for exoenzyme S synthesis in Pseudomonas aeruginosa. J. Bacteriol. 173:6460-6468.
    • (1991) J. Bacteriol , vol.173 , pp. 6460-6468
    • Frank, D.W.1    Iglewski, B.H.2
  • 12
    • 7744220530 scopus 로고    scopus 로고
    • A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa
    • Goodman, A. L., B. Kulasekara, A. Rietsch, D. Boyd, R. S. Smith, and S. Lory. 2004. A signaling network reciprocally regulates genes associated with acute infection and chronic persistence in Pseudomonas aeruginosa. Dev. Cell 7:745-754.
    • (2004) Dev. Cell , vol.7 , pp. 745-754
    • Goodman, A.L.1    Kulasekara, B.2    Rietsch, A.3    Boyd, D.4    Smith, R.S.5    Lory, S.6
  • 13
    • 69249157248 scopus 로고    scopus 로고
    • The type III secretion system of Pseudomonas aeruginosa: Infection by injection
    • Hauser, A. R. 2009. The type III secretion system of Pseudomonas aeruginosa: infection by injection. Nat. Rev. Microbiol. 7:654-665.
    • (2009) Nat. Rev. Microbiol , vol.7 , pp. 654-665
    • Hauser, A.R.1
  • 14
    • 0032575051 scopus 로고    scopus 로고
    • A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: Application for isolation of unmarked Pseudomonas aeruginosa mutants
    • Hoang, T. T., R. R. Karkhoff-Schweizer, A. J. Kutchma, and H. P. Schweizer. 1998. A broad-host-range Flp-FRT recombination system for site-specific excision of chromosomally-located DNA sequences: application for isolation of unmarked Pseudomonas aeruginosa mutants. Gene 212:77-86.
    • (1998) Gene , vol.212 , pp. 77-86
    • Hoang, T.T.1    Karkhoff-Schweizer, R.R.2    Kutchma, A.J.3    Schweizer, H.P.4
  • 15
    • 1942505740 scopus 로고    scopus 로고
    • Expression of Pseudomonas aeruginosa exoS is controlled by quorum sensing and RpoS
    • Hogardt, M., M. Roeder, A. M. Schreff, L. Eberl, and J. Heesemann. 2004. Expression of Pseudomonas aeruginosa exoS is controlled by quorum sensing and RpoS. Microbiology 150:843-851.
    • (2004) Microbiology , vol.150 , pp. 843-851
    • Hogardt, M.1    Roeder, M.2    Schreff, A.M.3    Eberl, L.4    Heesemann, J.5
  • 16
    • 14544291492 scopus 로고    scopus 로고
    • A three-component regulatory system regulates biofilm maturation and type III secretion in Pseudomonas aeruginosa
    • Kuchma, S. L., J. P. Connolly, and G. A. O'Toole. 2005. A three-component regulatory system regulates biofilm maturation and type III secretion in Pseudomonas aeruginosa. J. Bacteriol. 187:1441-1454.
    • (2005) J. Bacteriol , vol.187 , pp. 1441-1454
    • Kuchma, S.L.1    Connolly, J.P.2    O'Toole, G.A.3
  • 18
    • 37349027967 scopus 로고    scopus 로고
    • Gac/Rsm signal transduction pathway of gamma-proteobacteria: From RNA recognition to regulation of social behaviour
    • Lapouge, K., M. Schubert, F. H. Allain, and D. Haas. 2008. Gac/Rsm signal transduction pathway of gamma-proteobacteria: from RNA recognition to regulation of social behaviour. Mol. Microbiol. 67:241-253.
    • (2008) Mol. Microbiol , vol.67 , pp. 241-253
    • Lapouge, K.1    Schubert, M.2    Allain, F.H.3    Haas, D.4
  • 19
    • 0032483558 scopus 로고    scopus 로고
    • Solution structure of a TBPTAF(II)230 complex: Protein mimicry of the minor groove surface of the TATA box unwound by TBP
    • Liu, D., R. Ishima, K. I. Tong, S. Bagby, T. Kokubo, D. R. Muhandiram, L. E. Kay, Y. Nakatani, and M. Ikura. 1998. Solution structure of a TBPTAF(II)230 complex: protein mimicry of the minor groove surface of the TATA box unwound by TBP. Cell 94:573-583.
    • (1998) Cell , vol.94 , pp. 573-583
    • Liu, D.1    Ishima, R.2    Tong, K.I.3    Bagby, S.4    Kokubo, T.5    Muhandiram, D.R.6    Kay, L.E.7    Nakatani, Y.8    Ikura, M.9
  • 20
    • 33749362995 scopus 로고    scopus 로고
    • Characterization of ExsC and ExsD self-association and heterocomplex formation
    • Lykken, G. L., G. Chen, E. D. Brutinel, L. Chen, and T. L. Yahr. 2006. Characterization of ExsC and ExsD self-association and heterocomplex formation. J. Bacteriol. 188:6832-6840.
    • (2006) J. Bacteriol , vol.188 , pp. 6832-6840
    • Lykken, G.L.1    Chen, G.2    Brutinel, E.D.3    Chen, L.4    Yahr, T.L.5
  • 21
    • 0036434715 scopus 로고    scopus 로고
    • ExsD is a negative regulator of the Pseudomonas aeruginosa type III secretion regulon
    • McCaw, M. L., G. L. Lykken, P. K. Singh, and T. L. Yahr. 2002. ExsD is a negative regulator of the Pseudomonas aeruginosa type III secretion regulon. Mol. Microbiol. 46:1123-1133.
    • (2002) Mol. Microbiol , vol.46 , pp. 1123-1133
    • McCaw, M.L.1    Lykken, G.L.2    Singh, P.K.3    Yahr, T.L.4
  • 22
    • 0029084487 scopus 로고
    • Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: Protein mimicry of DNA
    • Mol, C. D., A. S. Arvai, R. J. Sanderson, G. Slupphaug, B. Kavli, H. E. Krokan, D. W. Mosbaugh, and J. A. Tainer. 1995. Crystal structure of human uracil-DNA glycosylase in complex with a protein inhibitor: protein mimicry of DNA. Cell 82:701-708.
    • (1995) Cell , vol.82 , pp. 701-708
    • Mol, C.D.1    Arvai, A.S.2    Sanderson, R.J.3    Slupphaug, G.4    Kavli, B.5    Krokan, H.E.6    Mosbaugh, D.W.7    Tainer, J.A.8
  • 23
    • 43449122166 scopus 로고    scopus 로고
    • The type III secretion system tip complex and translocon
    • Mueller, C. A., P. Broz, and G. R. Cornelis. 2008. The type III secretion system tip complex and translocon. Mol. Microbiol. 68:1085-1095.
    • (2008) Mol. Microbiol , vol.68 , pp. 1085-1095
    • Mueller, C.A.1    Broz, P.2    Cornelis, G.R.3
  • 25
    • 0033580277 scopus 로고    scopus 로고
    • Broad-host-range expression vectors that carry the L-arabinose-inducible Escherichia coli araBAD promoter and the araC regulator
    • Newman, J. R., and C. Fuqua. 1999. Broad-host-range expression vectors that carry the L-arabinose-inducible Escherichia coli araBAD promoter and the araC regulator. Gene 227:197-203.
    • (1999) Gene , vol.227 , pp. 197-203
    • Newman, J.R.1    Fuqua, C.2
  • 26
    • 20344407810 scopus 로고    scopus 로고
    • A secreted anti-activator, OspD1, and its chaperone, Spa15, are involved in the control of transcription by the type III secretion apparatus activity in Shigella flexneri
    • Parsot, C., E. Ageron, C. Penno, M. Mavris, K. Jamoussi, H. d'Hauteville, P. Sansonetti, and B. Demers. 2005. A secreted anti-activator, OspD1, and its chaperone, Spa15, are involved in the control of transcription by the type III secretion apparatus activity in Shigella flexneri. Mol. Microbiol. 56:1627-1635.
    • (2005) Mol. Microbiol , vol.56 , pp. 1627-1635
    • Parsot, C.1    Ageron, E.2    Penno, C.3    Mavris, M.4    Jamoussi, K.5    d'Hauteville, H.6    Sansonetti, P.7    Demers, B.8
  • 27
    • 20344403312 scopus 로고    scopus 로고
    • ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa
    • Rietsch, A., I. Vallet-Gely, S. L. Dove, and J. J. Mekalanos. 2005. ExsE, a secreted regulator of type III secretion genes in Pseudomonas aeruginosa. Proc. Natl. Acad. Sci. U. S. A. 102:8006-8011.
    • (2005) Proc. Natl. Acad. Sci. U. S. A , vol.102 , pp. 8006-8011
    • Rietsch, A.1    Vallet-Gely, I.2    Dove, S.L.3    Mekalanos, J.J.4
  • 28
    • 67650133652 scopus 로고    scopus 로고
    • Anti-activator ExsD forms a 1:1 complex with ExsA to inhibit transcription of type III secretion operons
    • Thibault, J., E. Faudry, C. Ebel, I. Attree, and S. Elsen. 2009. Anti-activator ExsD forms a 1:1 complex with ExsA to inhibit transcription of type III secretion operons. J. Biol. Chem. 284:15762-15770.
    • (2009) J. Biol. Chem , vol.284 , pp. 15762-15770
    • Thibault, J.1    Faudry, E.2    Ebel, C.3    Attree, I.4    Elsen, S.5
  • 29
    • 34548475821 scopus 로고    scopus 로고
    • Translocation of ExsE into Chinese hamster ovary cells is required for transcriptional induction of the Pseudomonas aeruginosa type III secretion system
    • Urbanowski, M. L., E. D. Brutinel, and T. L. Yahr. 2007. Translocation of ExsE into Chinese hamster ovary cells is required for transcriptional induction of the Pseudomonas aeruginosa type III secretion system. Infect. Immun. 75:4432-4439.
    • (2007) Infect. Immun , vol.75 , pp. 4432-4439
    • Urbanowski, M.L.1    Brutinel, E.D.2    Yahr, T.L.3
  • 30
    • 22244459205 scopus 로고    scopus 로고
    • A secreted regulatory protein couples transcription to the secretory activity of the Pseudomonas aeruginosa type III secretion system
    • Urbanowski, M. L., G. L. Lykken, and T. L. Yahr. 2005. A secreted regulatory protein couples transcription to the secretory activity of the Pseudomonas aeruginosa type III secretion system. Proc. Natl. Acad. Sci. U. S. A. 102:9930-9935.
    • (2005) Proc. Natl. Acad. Sci. U. S. A , vol.102 , pp. 9930-9935
    • Urbanowski, M.L.1    Lykken, G.L.2    Yahr, T.L.3
  • 31
    • 70350455920 scopus 로고    scopus 로고
    • Mechanism of transcriptional activation by Pseudomonas aeruginosa ExsA
    • Vakulskas, C. A., K. M. Brady, and T. L. Yahr. 2009. Mechanism of transcriptional activation by Pseudomonas aeruginosa ExsA. J. Bacteriol. 191:6654-6664.
    • (2009) J. Bacteriol , vol.191 , pp. 6654-6664
    • Vakulskas, C.A.1    Brady, K.M.2    Yahr, T.L.3
  • 33
    • 77049313195 scopus 로고
    • Acetylornithinase of Escherichia coli: Partial purification and some properties
    • Vogel, H. J., and D. M. Bonner. 1956. Acetylornithinase of Escherichia coli: partial purification and some properties. J. Biol. Chem. 218:97-106.
    • (1956) J. Biol. Chem , vol.218 , pp. 97-106
    • Vogel, H.J.1    Bonner, D.M.2
  • 34
    • 0037322193 scopus 로고    scopus 로고
    • Coordinate regulation of bacterial virulence genes by a novel adenylate cyclase-dependent signaling pathway
    • Wolfgang, M. C., V. T. Lee, M. E. Gilmore, and S. Lory. 2003. Coordinate regulation of bacterial virulence genes by a novel adenylate cyclase-dependent signaling pathway. Dev. Cell 4:253-263.
    • (2003) Dev. Cell , vol.4 , pp. 253-263
    • Wolfgang, M.C.1    Lee, V.T.2    Gilmore, M.E.3    Lory, S.4
  • 35
    • 7744241363 scopus 로고    scopus 로고
    • MucA-mediated coordination of type III secretion and alginate synthesis in Pseudomonas aeruginosa
    • Wu, W., H. Badrane, S. Arora, H. V. Baker, and S. Jin. 2004. MucA-mediated coordination of type III secretion and alginate synthesis in Pseudomonas aeruginosa. J. Bacteriol. 186:7575-7585.
    • (2004) J. Bacteriol , vol.186 , pp. 7575-7585
    • Wu, W.1    Badrane, H.2    Arora, S.3    Baker, H.V.4    Jin, S.5
  • 36
    • 33749175594 scopus 로고    scopus 로고
    • Transcriptional regulation of the Pseudomonas aeruginosa type III secretion system
    • Yahr, T. L., and M. C. Wolfgang. 2006. Transcriptional regulation of the Pseudomonas aeruginosa type III secretion system. Mol. Microbiol. 62:631-640.
    • (2006) Mol. Microbiol , vol.62 , pp. 631-640
    • Yahr, T.L.1    Wolfgang, M.C.2
  • 37
    • 34250318628 scopus 로고    scopus 로고
    • Biochemical characterization of a regulatory cascade controlling transcription of the Pseudomonas aeruginosa type III secretion system
    • Zheng, Z., G. Chen, S. Joshi, E. D. Brutinel, T. L. Yahr, and L. Chen. 2007. Biochemical characterization of a regulatory cascade controlling transcription of the Pseudomonas aeruginosa type III secretion system. J. Biol. Chem. 282:6136-6142.
    • (2007) J. Biol. Chem , vol.282 , pp. 6136-6142
    • Zheng, Z.1    Chen, G.2    Joshi, S.3    Brutinel, E.D.4    Yahr, T.L.5    Chen, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.