Gene expression patterns of normal human skin, actinic keratosis, and squamous cell carcinoma: A spectrum of disease progression

Archives of Dermatology

Volumn 146, Issue 3, 2010, Pages 288-293

  Padilla, R Steven ^a,b   Sebastian, Sheldon ^a,d   Jiang, Zeyu ^b   Nindl, Ingo ^c   Larson, Richard ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d Dermatology and Skin Cancer Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINIC KERATOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; MICROARRAY ANALYSIS; MUTATION; PRIORITY JOURNAL; SKIN BIOPSY; SKIN CARCINOMA; SKIN DEFECT; SQUAMOUS CELL CARCINOMA; SUN EXPOSURE;

BIOPSY; CARCINOMA, SQUAMOUS CELL; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; KERATOSIS, ACTINIC; MALE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA; SKIN; SKIN NEOPLASMS;

EID: 77949404061     PISSN: 0003987X     EISSN: 15383652     Source Type: Journal    
DOI: 10.1001/archdermatol.2009.378     Document Type: Article

References (19)

1. American Cancer Society. Cancer Facts & Figures 2008. Atlanta, GA: American Cancer Society; 2008.
2. Brash DE, Ponten J. Skin precancer. Cancer Surv. 1998;32:69-113.
3. Miller SJ, Maloney ME, eds. Cutaneous Oncology. Oxford, England: Blackwell Science; 1998.
4. Liang SB, Ohtsuki Y, Furihata M, et al. Sun-exposure- and aging-dependent p53 protein accumulation results in growth advantage for tumor cells in carcinogenesis of nonmelanocytic skin cancer. Virchows Arch. 1999;434(3):193-199.
5. Jonason AS, Kunala S, Price GJ, et al. Frequent clones of p53-mutated keratinocytes in normal human skin. Proc Natl Acad Sci U S A. 1996;93(24):14025-14029.
6. Williams C, Ponten F, Ahmadian A, et al. Clones of normal keratinocytes and a variety of simultaneously present epidermal neoplastic lesions contain a multitude of p53 gene mutations in a xeroderma pigmentosum patient. Cancer Res. 1998;58(11):2449-2455.
7. Einspahr J, Alberts DS, Aickin M, et al. Expression of p53 protein in actinic keratosis, adjacent, normal-appearing, and non-sun-exposed human skin. Cancer Epidemiol Biomarkers Prev. 1997;6(8):583-587.
8. Mittelbronn MA, Mullins DL, Ramos-Caro FA, Flowers FP. Frequency of pre-existing actinic keratosis in cutaneous squamous cell carcinoma. Int J Dermatol. 1998;37(9):677-681.
9. Marks R. Squamous cell carcinoma. Lancet. 1996;347(9003):735-738.
10. Park WS, Lee HK, Lee JY, Yoo NJ, Kim CS, Kim SH. p53 Mutations in solar keratoses. Hum Pathol. 1996;27(11):1180-1184.
11. Nagano T, Ueda M, Ichihashi M. Expression of p53 protein is an early event in ultraviolet light-induced cutaneous squamous cell carcinogenesis. Arch Dermatol. 1993;129(9):1157-1161.
12. Nelson MA, Einspahr JG, Alberts DS, et al. Analysis of the p53 gene in human precancerous actinic keratosis lesions and squamous cell cancers. Cancer Lett. 1994;85(1):23-29.
13. Taguchi M, Watanabe S, Yashima K, Murakami Y, Sekiya T, Ikeda S. Aberrations of the tumor suppressor p53 gene and p53 protein in solar keratosis in human skin. J Invest Dermatol. 1994;103(4):500-503.
14. Pelengaris S, Littlewood T, Khan M, Elia G, Evan G. Reversible activation of c-Myc in skin: induction of a complex neoplastic phenotype by a single oncogenic lesion. Mol Cell. 1999;3(5):565-577.
15. ARF expression occurs frequently in human nonmelanoma skin cancers. Br J Dermatol. 2008;158(2):291-297.
16. Mäkelä M, Larjava H, Pirila E, et al. Matrix metalloproteinase 2 (gelatinase A) is related to migration of keratinocytes. Exp Cell Res. 1999;251(1):67-78.
17. Sakaki T, Wato M, Kaji R, Mushimoto K, Shirasu R, Tanaka A. Correlation of E-and P-cadherin expression with differentiation grade and mode of invasion in gingival carcinoma. Pathol Int. 1994;44(4):280-286.
18. Peddada SD, Lobenhofer EK, Li L, Afshari CA, Weinberg CR, Umbach DM. Gene selection and clustering for time-course and dose-response microarray experiments using order-restricted inference. Bioinformatics. 2003;19(7):834-841.
19. Nindl I, Dang C, Forschner T, et al. Identification of differentially expressed genes in cutaneous squamous cell carcinoma by microarray expression profiling. Mol Cancer. 2006;5:e30. doi:10.1186/1476-4598-5-30.