Topical treatment of actinic keratoses with piroxicam 1 gel: A preliminary open-label study utilizing a new clinical score

American Journal of Clinical Dermatology

Volumn 11, Issue 1, 2010, Pages 45-50

  Campione, Elena ^a   Diluvio, Laura ^a   Paternò, Evelin Jasmine ^a   Chimenti, Sergio ^a  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

PIROXICAM;

ACTINIC KERATOSIS; ADULT; AGED; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG ERUPTION; DRUG TOLERABILITY; DRY SKIN; EPILUMINESCENCE MICROSCOPY; ERYTHEMA; FEMALE; GEL; HUMAN; MALE; PRIORITY JOURNAL; PRURITUS; REMISSION; SCORING SYSTEM; SKIN ATROPHY; TREATMENT DURATION; TREATMENT RESPONSE;

EID: 77949389187     PISSN: 11750561     EISSN: 11791888     Source Type: Journal    
DOI: 10.2165/11311170-000000000-00000     Document Type: Article

References (33)

1. Salasche SJ. Epidemiology of actinic keratoses and squamous cell carcinoma. J Am Acad Dermatol 2000; 42: 4-7
2. Moller R, Reymann F, Hou-Jensen K. Metastases in dermatological patients with squamous cell carcinoma. Arch Dermatol 1979; 115: 703-705
3. Black J, Herd A, Goldberg LH, et al. Effect of a low-fat diet on the incidence of actinic keratosis. N Engl J Med 1994; 330: 1272-1275
4. Boyle J, MacKie RM, Briggs JD, et al. Cancer, warts, and sunshine in renal transplant patients: a case-control study. Lancet 1994; I: 702-705
5. McGreor JM, Barker JN, MacDonald DM. The development of excess num-bers of melanocyte naevi in an immunosuppressed identical twin. Clin Exp Dermatol 1991; 16: 131-132
6. Jackson S, Storey A. E6 protein from diverse cutaneous HPV types inhibit apoptosis in response to UV damage. Oncogene 2000; 19: 592-598
7. Jackson S, Harwood C,ThomasM,et al. Role ofBak in UV-induced apoptosis in skin cancer and abrogation byHPV E6 protein. Genes Dev 2000; 14: 3065-3073
8. Braakius BJM, Tabor MP, Kummer JA, et al. A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications. Cancer Res 2003; 63: 1727-1730
9. Callen JP, Bickers DR, May RL. Actinic keratoses. J Am Acad Dermatol 1997; 36: 650-653
10. Ashton KJ, Weinstein SR, Maguire DJ, et al. Chromosomal aberrations in squamous cell carcinoma and solar keratoses revealed by comparative genomic hybridization. Arch Dermatol 2003; 139: 876-882
11. Berhane T, Halliday GM, Cooke B, et al. Inflammation is associated with progression of actinic keratoses to squamous cell carcinomas in humans. Br J Dermatol 2002; 146: 810-815
12. Szeimies RM, Karrer S, Radakovic-Fijan S, et al. Photodynamic therapy using topical methyl 5-aminolevulinat compared with cryotherapy for actinic ker-atosis: a prospective, randomized study. J Am Acad Dermatol 2002; 47: 258-262
13. Gupta AK. The management of actinic keratoses in the United States with topical fluorouracil: a pharmacoeconomic evaluation. Cutis 2002; 70: 30-36
14. Moriarti M, Dunn J, Darragh A, et al. Etretinate in treatment of actinic ker-atosis: a double-blind cross-over study. Lancet 1982; 13: 364-365
15. Campanelli A, Naldi L. A retrospective study of the effect of long-term topical application of retinaldehyde (0.05%) on the development of actinic keratosis. Dermatology 2000; 205: 146-152
16. Tarstdedt M, Rosdahl I, Berne B, et al. A randomized multicenter study to compare two treatment regimens of topical methyl aminolevulinate (Metvix)-PDT in actinic keratosis of the face and scalp. Acta Derm Venereol 2005; 85: 424-428
17. Lebwohl M, Dinehart S, Whiting D, et al. Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials. J Am Acad Dermatol 2004; 50: 714-721
18. Zhan H, Zheng H. The role of topical cyclo-oxygenase-2 inhibitors in skin cancer: treatment and prevention. Am J Clin Dermatol 2007; 8: 195-200
19. Stockfleth E, Kerl H. Guideline Subcommittee of the European Dermatology Forum: guidelines for the management of actinic keratoses. Eur J Dermatol 2006; 16: 599-606
20. Rivers JK, Arlette J, Shear N, et al. Topical treatment of actinic keratoses with 3.0% diclofenac in 2.5% hyaluronan gel. Br J Dermatol 2002; 146: 194-200
21. Di Bernardi L, Dore M, Davis JA, et al. Study of feline oral squamous cell carcinoma: potential target for cyclooxygenase inhibitor treatment. J PLEFA 2007; 76: 245-250
22. Fitzpatrick TB. The validity and practicability of sun reactive skin types I through VI. Arch Dermatol 1988; 124: 869-871
23. Zalaudek I, Giacomel J, Argenziano G, et al. Dermoscopy of facial non-pigmented actinic keratosis. Br J Dermatol 2006; 155: 951-956
24. Chan G, Boyle JO, Yang EK, et al. Cyclooxygenase-2 expression is up-regulated in squamous cell carcinoma of the head and neck. Cancer Res 1999; 59: 991-994
25. Leung WK, To KF, Ng TP, et al. Association between cyclo-oxygenase-2 overexpression and missense p53 mutations in gastric cancer. Br J Cancer 2001; 84: 335-339
26. Buckman SY, Gresham A, Hale P, et al. COX-2 expression is induced by UVB exposure in human skin: implications for the development of skin cancer. Carcinogenesis 1998; 19: 723-729
27. Nakagawa K, Yamamura K, Maeda S, et al. Bcl-2 expression in epidermal keratinocytic diseases. Cancer 1994; 74: 1720-1724
28. Tiano HF, Lofrin CD, Akunda J, et al. Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. Cancer Res 2002; 62: 3395-3401
29. Rivers JK, McLean DI. An open study to assess the efficacy and safety of topical 3% diclofenac in a 2.5% hyaloronic acid gel for the treatment of actinic keratoses. Arch Dermatol 1997; 133: 1239-1242
30. Nelson C, Rigel D, Smith S, et al. Phase IV, open-label assessment of the treatment of actinic keratosis with 3.0% diclofenac sodium topical gel (Solaraze). J Drugs Dermatol 2004; 3: 401-407
31. Wolf Jr JE, Taylor JR, Tschen E, et al. Topical 3.0% diclofenac in 2.5% hyaluronan gel in the treatment of actinic keratoses. Int J Dermatol 2001; 40: 709-713
32. Gebauer K, Brown P, Varigos G. Topical diclofenac in hyaluronan gel for the treatment of solar keratoses. Australas J Dermatol 2003; 44: 40-43
33. Butler GJ, Neale R, Green AC, et al. Non-steroidal anti-inflammatory drugs and the risk of actinic keratoses and squamous cell cancers of the skin. J Am Acad Dermatol 2005; 53: 966-972