Circadian stage-dependent inhibition of human breast cancer metabolism and growth by the nocturnal melatonin signal: Consequences of its disruption by light at night in rats and women

Integrative Cancer Therapies

Volumn 8, Issue 4, 2009, Pages 347-353

  Blask, David E ^a   Dauchy, Robert T ^a   Brainard, George C ^b   Hanifin, John P ^b  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Breast cancer; Circadian disruption; Light at night; Melatonin; Tumor metabolism

Indexed keywords

CORIOLIC ACID; CYCLIC AMP; ESTROGEN RECEPTOR ALPHA; LINOLEIC ACID; MELATONIN; MELATONIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OMEGA 6 FATTY ACID;

BREAST CANCER; CANCER GROWTH; CANCER INHIBITION; CANCER RISK; CELL PROLIFERATION; CELL STRAIN MCF 7; CELL SURVIVAL; CIRCADIAN RHYTHM; DNA CONTENT; FATTY ACID TRANSPORT; FEMALE; HUMAN; HUMAN CELL; LIGHT EXPOSURE; LIGHT INTENSITY; METABOLISM; NIGHT; NIGHTTIME LIGHT; NONHUMAN; NUDE RAT; PINEAL BODY; PRIORITY JOURNAL; RAT; REVIEW; SIGNAL TRANSDUCTION; TUMOR METABOLISM; TUMOR XENOGRAFT;

ANIMALS; ANTICARCINOGENIC AGENTS; BREAST NEOPLASMS; CELL GROWTH PROCESSES; CELL PROLIFERATION; CIRCADIAN RHYTHM; FEMALE; HUMANS; LIGHT; LINOLEIC ACID; LINOLEIC ACIDS; MELATONIN; NEOPLASM TRANSPLANTATION; PHOTOPERIOD; RATS; RATS, NUDE; RECEPTORS, MELATONIN; SIGNAL TRANSDUCTION; TRANSPLANTATION, HETEROLOGOUS;

EID: 77949388493     PISSN: 15347354     EISSN: 1552695X     Source Type: Journal    
DOI: 10.1177/1534735409352320     Document Type: Review

References (22)

1. Hrushesky WJM. The temporal organization of life: the impact of multifrequency non-linear biological time structure upon the host-cancer balance. Jpn J Clin Oncol. 2000;30:529-533.
2. Canaple L, Kakizawa T, Laudet V. The days and nights of cancer cells. Cancer Res. 2003;63:7545-7552.
3. Blask DE, Dauchy RT, Sauer LA. Putting cancer to sleep at night: the neuroendocrine/circadian melatonin signal. Endocrine. 2005;27:179-188.
4. Blask DE, Sauer LA, Dauchy RT. Melatonin as a chronobiotic/ anticancer agent: cellular, biochemical, and molecular mechanisms of action and their implications for circadian-based cancer therapy. Curr Top Med Chem. 2002;2:113-132.
5. Sauer LA, Dauchy RT, Blask DE. Polyunsaturated fatty acids, melatonin, and cancer prevention. Biochem Pharmacol. 2001;61:1455-1462.
6. Blask DE, Brainard GC, Dauchy RT, et al. Melatonin-depleted blood from premenopausal women exposed to light at night stimulates growth of human breast cancer xenografts in nude rats. Cancer Res. 2005;65:11174-11184.
7. 1 receptor-mediated suppression of signal transduction and linoleic acid uptake and metabolism [abstract 5776]. Am Assoc Cancer Res. 2005;46:1358.
8. Cos S, Mediavilla D, Martinez-Campa C, et al. Exposure to light-at-night increases the growth of DMBA-induced mammary adenocarcinoma in rats. Cancer Lett. 2006;235:266-271.
9. Stevens RG, London SJ. Breast cancer. In: Stevens RG, Wilson BW, Anderson LE, eds. The Melatonin Hypothesis: Breast Cancer and the Use of Electric Power. Columbus, OH: Battelle Press; 1997:9-24.
10. Stevens RG. Electric power use and breast cancer: a hypothesis. Am J Epidemiol. 1987;125:556-561.
11. Stevens RG, Rea MS. Light in the built-in environment: potential role of circadian disruption in endocrine disruption and breast cancer. Cancer Causes Control. 2001;12:279-287.
12. Stevens RG, Blask DE, Brainard GC, et al. Meeting report: the role of environmental lighting and circadian disruption in cancer and other diseases. Environ Health Perspect. 2007;115: 1357-1362.
13. Hansen J. Increased breast cancer among women who work predominantly at night. Epidemiology. 2002;12:74-77.
14. Davis S, Mirick DK, Stevens RG. Night shift work, light at night, and risk of breast cancer. J Natl Cancer Inst. 2001;93: 1557-1562.
15. Schernhammer ES, Laden F, Speizer FE, et al. Rotating night shifts and risk of breast cancer in women participating in the nurses' health study. J Natl Cancer Inst. 2001;93:1563-1568.
16. Schernhammer ES, Kroenke CH, Laden F, et al. Night work and risk of breast cancer. Epidemiology. 2006;17:108-111.
17. Viswanathan AN, Hankinson SE, Schernhammer ES. Night shift work and the risk of endometrial cancer. Cancer Res. 2007;67:10618-10622.
18. Schernhammer ES, Laden F, Speizer FE, et al. Night-shift work and risk of colorectal cancer in the nurses' health study. J Natl Cancer Inst. 2003;95:825-828.
19. Kubo T, Ozasa K, Mikami K, et al. Prospective cohort study of the risk of prostate cancer among rotating-shift workers: findings from the Japan collaborative cohort study. Am J Epidemiol. 2006;164:549-555.
20. Schernhammer ES, Hankinson SE. Urinary melatonin levels and breast cancer risk. J Natl Cancer Inst. 2005; 97:1084-1087.
21. Schernhammer ES, Berrino F, Krogh V, et al. Urinary 6-sulfatoxymelatonin levels and risk of breast cancer in postmenopausal women. J Natl Cancer Inst. 2008;100:898-905.
22. You S, Wood PA, Xiong Y, et al. Daily coordination of cancer growth and circadian clock gene expression. Breast Cancer Res Treat. 2005;91:47-60.