The 5-lipoxygenase pathway regulates vasculogenesis in differentiating mouse embryonic stem cells

Cardiovascular Research

Volumn 86, Issue 1, 2010, Pages 37-44

  Finkensieper, Andreas ^a   Kieser, Sophia ^a   Bekhite, Mohamed M ^a   Richter, Madeleine ^a   Mueller, Joerg P ^a   Graebner, Rolf ^a   Figulla, Hans Reiner ^a   Sauer, Heinrich ^b   Wartenberg, Maria ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

5 lipoxygenase; 5 lipoxygenase activating protein; Embryoid body; Embryonic stem cells; Leukotrienes

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CALCIUM; CD31 ANTIGEN; CD45 ANTIGEN; CHLORDANE; ENDOGLIN; LEUKOTRIENE B4; LEUKOTRIENE D4; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; SHORT HAIRPIN RNA; VASCULOTROPIN RECEPTOR 2;

ANGIOGENESIS; ARTICLE; CELL DIFFERENTIATION; EMBRYONIC STEM CELL; ENZYME PHOSPHORYLATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; TREATMENT RESPONSE; WESTERN BLOTTING;

ANIMALS; ARACHIDONATE 5-LIPOXYGENASE; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL LINEAGE; CELLS, CULTURED; EMBRYONIC STEM CELLS; EPOXIDE HYDROLASES; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUTATHIONE TRANSFERASE; LEUKOTRIENE B4; LEUKOTRIENE D4; LEUKOTRIENES; LYMPHOCYTES; MACROPHAGES; MEMBRANE PROTEINS; MICE; NEOVASCULARIZATION, PATHOLOGIC; PHOSPHORYLATION; RECEPTORS, LEUKOTRIENE; RECEPTORS, LEUKOTRIENE B4; RNA, MESSENGER; RNA, SMALL INTERFERING; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 77949373676     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvp385     Document Type: Article

References (39)

1. Imhof BA, Aurrand-Lions M. Angiogenesis and inflammation face off. Nat Med 2006;12:171-172.
2. Kalantaridou SN, Zoumakis E, Makrigiannakis A, Godoy H, Chrousos GP. The role of corticotropin-releasing hormone in blastocyst implantation and early fetal immunotolerance. Horm Metab Res 2007;39:474-477.
3. Arnold F, West DC. Angiogenesis in wound healing. Pharmacol Ther 1991;52:407-422.
4. Jackson JR, Seed MP, Kircher CH, Willoughby DA, Winkler JD. The codependence of angiogenesis and chronic inflammation. FASEB J 1997;11:457-465.
5. Akino K, Mineda T, Mori N, Hirano A, Imaizumi T, Akita S. Attenuation of cysteinyl leukotrienes induces human mesenchymal stem cell differentiation. Wound Repair Regen 2006;14:343-349.
6. Miki T, Miura T, Nishino Y, Yano T, Sakamoto J, Nakamura Y et al. Granulocyte colony stimulating factor/macrophage colony stimulating factor improves postinfarct ventricular function by suppression of border zone remodelling in rats. Clin Exp Pharmacol Physiol 2004;31:873-882.
7. Williams JD, Czop JK, Austen KF. Release of leukotrienes by human monocytes on stimulation of their phagocytic receptor for particulate activators. J Immunol 1984;132:3034-3040.
8. Goldyne ME, Burrish GF, Poubelle P, Borgeat P. Arachidonic acid metabolism among human mononuclear leukocytes. Lipoxygenase-related pathways. J Biol Chem 1984;259:8815-8819.
9. Maclouf J, Fitzpatrick FA, Murphy RC. Transcellular biosynthesis of eicosanoids. Pharmacol Res 1989;21:1-7.
10. Peters-Golden M, Brock TG. 5-lipoxygenase and FLAP. Prostaglandins Leukot Essent Fatty Acids 2003;69:99-109.
11. Vickers PJ. 5-Lipoxygenase-activating protein (FLAP). J Lipid Mediat Cell Signal 1995;12:185-194.
12. Lotzer K, Funk CD, Habenicht AJ. The 5-lipoxygenase pathway in arterial wall biology and atherosclerosis. Biochim Biophys Acta 2005;1736:30-37.
13. Flamand N, Surette ME, Picard S, Bourgoin S, Borgeat P. Cyclic AMP-mediated inhibition of 5-lipoxygenase translocation and leukotriene biosynthesis in human neutrophils. Mol Pharmacol 2002;62:250-256.
14. Rouzer CA, Shimizu T, Samuelsson B. On the nature of the 5-lipoxygenase reaction in human leukocytes: characterization of a membrane-associated stimulatory factor. Proc Natl Acad Sci USA 1985;82:7505-7509.
15. Ciana P, Fumagalli M, Trincavelli ML, Verderio C, Rosa P, Lecca D et al. The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor. EMBO J 2006;25:4615- 4627.
16. Tsopanoglou NE, Pipili-Synetos E, Maragoudakis ME. Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction. Eur J Pharmacol 1994;258:151-154.
17. Vittet D, Prandini MH, Berthier R, Schweitzer A, Martin-Sisteron H, Uzan G et al. Embryonic stem cells differentiate in vitro to endothelial cells through successive maturation steps. Blood 1996;88:3424-3431.
18. Hannig M, Figulla HR, Sauer H, Wartenberg M. Control of leukocyte differentiation from embryonic stem cells upon vasculogenesis and confrontation with tumour tissue. J Cell Mol Med 2008; doi:10.1111/j.1582-4934.2008. 00424.x. Published online ahead of print 9 July 2008.
19. Keller G, Kennedy M, Papayannopoulou T, Wiles MV. Hematopoietic commitment during embryonic stem cell differentiation in culture. Mol Cell Biol 1993;13:473-486.
20. de Pooter RF, Cho SK, Carlyle JR, Zuniga-Pflucker JC. In vitro generation of T lymphocytes from embryonic stem cell-derived prehematopoietic progenitors. Blood 2003;102:1649-1653.
21. de Pooter RF, Cho SK, Zuniga-Pflucker JC. In vitro generation of lymphocytes from embryonic stem cells. Methods Mol Biol 2005;290:135-147.
22. Senju S, Hirata S, Matsuyoshi H, Masuda M, Uemura Y, Araki K et al. Generation and genetic modification of dendritic cells derived from mouse embryonic stem cells. Blood 2003;101:3501-3508.
23. Sauer H, Bekhite MM, Hescheler J, Wartenberg M. Redox control of angiogenic factors and CD31-positive vessel-like structures in mouse embryonic stem cells after direct current electrical field stimulation. Exp Cell Res 2005;304:380-390.
24. Lotzer K, Spanbroek R, Hildner M, Urbach A, Heller R, Bretschneider E et al. Differential leukotriene receptor expression and calcium responses in endothelial cells and macrophages indicate 5-lipoxygenase-dependent circuits of inflammation and atherogenesis. Arterioscler Thromb Vasc Biol 2003;23:e32-e36.
25. Sauer H, Ruhe C, Muller JP, Schmelter M, D'Souza R,Wartenberg M. Reactive oxygen species and upregulation of NADPH oxidases in mechanotransduction of embryonic stem cells. Methods Mol Biol 2008;477:397-418.
26. Unger WG, Stamford IF, Bennett A. Extraction of prostaglandins from human blood. Nature 1971;233:336-337.
27. Fels AO, Pawlowski NA, Cramer EB, King TK, Cohn ZA, Scott WA. Human alveolar macrophages produce leukotriene B4. Proc Natl Acad Sci USA 1982;79:7866-7870.
28. Ribatti D, Crivellato E. Immune cells and angiogenesis. J Cell Mol Med 2009; doi:10.1111/j.1582-4934.2009.00810.x. Published online ahead of print 16 June 2009.
29. Wartenberg M, Gunther J, Hescheler J, Sauer H. The embryoid body as a novel in vitro assay system for antiangiogenic agents. Lab Invest 1998;78:1301-1314.
30. Albert D, Pergola C, Koeberle A, Dodt G, Steinhilber D, Werz O. The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5-lipoxygenase in polymorphonuclear leukocytes. J Leukoc Biol 2008;83:1019-1027.
31. Koshino T, Takano S, Houjo T, Sano Y, Kudo K, Kihara H et al. Expression of 5- lipoxygenase and 5-lipoxygenase-activating protein mRNAs in the peripheral blood leukocytes of asthmatics. Biochem Biophys Res Commun 1998;247:510-513.
32. Spanbroek R, Grabner R, Lotzer K, Hildner M, Urbach A, Ruhling K et al. Expanding expression of the 5-lipoxygenase pathway within the arterial wall during human atherogenesis. Proc Natl Acad Sci USA 2003;100:1238-1243.
33. Sjostrom M, Jakobsson PJ, Juremalm M, Ahmed A, Nilsson G, Macchia L et al. Human mast cells express two leukotriene C(4) synthase isoenzymes and the CysLT(1) receptor. Biochim Biophys Acta 2002;1583:53-62.
34. Thivierge M, Stankova J, Rola-Pleszczynski M. IL-13 and IL-4 up-regulate cysteinyl leukotriene 1 receptor expression in human monocytes and macrophages. J Immunol 2001;167:2855-2860.
35. Maekawa A, Austen KF, Kanaoka Y. Targeted gene disruption reveals the role of cysteinyl leukotriene 1 receptor in the enhanced vascular permeability of mice undergoing acute inflammatory responses. J Biol Chem 2002;277:20820-20824.
36. Qiu H, Johansson AS, Sjostrom M, Wan M, Schroder O, Palmblad J et al. Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4. Proc Natl Acad Sci USA 2006;103:6913-6918.
37. Uzonyi B, Lotzer K, Jahn S, Kramer C, Hildner M, Bretschneider E et al. Cysteinyl leukotriene 2 receptor and protease-activated receptor 1 activate strongly correlated early genes in human endothelial cells. Proc Natl Acad Sci USA 2006;103:6326-6331.
38. Sanchez-Galan E, Gomez-Hernandez A, Vidal C, Martin-Ventura JL, Blanco-Colio LM, Munoz-Garcia B et al. Leukotriene B4 enhances the activity of nuclear factor-kappaB pathway through BLT1 and BLT2 receptors in atherosclerosis. Cardiovasc Res 2009;81:216-225.
39. Mehrabian M, Allayee H, Wong J, Shi W, Wang XP, Shaposhnik Z et al. Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in mice. Circ Res 2002;91:120-126.