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Volumn 5, Issue 2, 2010, Pages

Ghrelin stimulation of growth hormone-releasing hormone neurons is direct in the arcuate nucleus

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 4 AMINOBUTYRIC ACID; CALCIUM CHANNEL BLOCKING AGENT; GHRELIN; GHRELIN RECEPTOR; GLUTAMIC ACID; GROWTH HORMONE RELEASING FACTOR; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; SOMATOSTATIN; 1 (6 ((3 METHOXYESTRA 1,3,5(10) TRIEN 17 YL)AMINO)HEXYL) 1H PYRROLE 2,5 DIONE; 1-(6-((3-METHOXYESTRA-1,3,5(10)-TRIEN-17-YL)AMINO)HEXYL)-1H-PYRROLE-2,5-DIONE; 2 PYRROLIDONE DERIVATIVE; AIB TRP GTRP CHO; AIB-TRP-GTRP-CHO; CALCIUM CHANNEL; ESTRANE DERIVATIVE; GREEN FLUORESCENT PROTEIN; GROWTH HORMONE RELEASING HEXAPEPTIDE; OLIGOPEPTIDE; PHOSPHOLIPASE C;

EID: 77949366418     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0009159     Document Type: Article
Times cited : (63)

References (72)
  • 1
    • 34147177520 scopus 로고    scopus 로고
    • Model-projected mechanistic bases for sex differences in growth hormone regulation in humans
    • Farhy LS, Bowers CY, Veldhuis JD (2007) Model-projected mechanistic bases for sex differences in growth hormone regulation in humans. Am J Physiol Regul Integr Comp Physiol 292: R1577-93.
    • (2007) Am J Physiol Regul Integr Comp Physiol , vol.292
    • Farhy, L.S.1    Bowers, C.Y.2    Veldhuis, J.D.3
  • 2
    • 48849107624 scopus 로고    scopus 로고
    • Brain circuits regulating energy homeostasis
    • Abizaid A, Horvath TL (2008) Brain circuits regulating energy homeostasis. Regul Pept 149: 3-10.
    • (2008) Regul Pept , vol.149 , pp. 3-10
    • Abizaid, A.1    Horvath, T.L.2
  • 3
    • 0021322884 scopus 로고
    • On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone
    • Bowers CY, Momany FA, Reynolds GA, Hong A (1984) On the in vitro and in vivo activity of a new synthetic hexapeptide that acts on the pituitary to specifically release growth hormone. Endocrinology 114: 1537-45.
    • (1984) Endocrinology , vol.114 , pp. 1537-1545
    • Bowers, C.Y.1    Momany, F.A.2    Reynolds, G.A.3    Hong, A.4
  • 4
    • 18844404431 scopus 로고    scopus 로고
    • Development of growth hormone secretagogues
    • Smith RG (2005) Development of growth hormone secretagogues. Endocr Rev 26: 346-360.
    • (2005) Endocr Rev , vol.26 , pp. 346-360
    • Smith, R.G.1
  • 6
    • 33747625691 scopus 로고    scopus 로고
    • Biological, physiological, and pharmacological aspects of ghrelin
    • Hosoda H, Kojima M, Kangawa K (2006) Biological, physiological, and pharmacological aspects of ghrelin. J Pharmacol Sci 100: 398-410.
    • (2006) J Pharmacol Sci , vol.100 , pp. 398-410
    • Hosoda, H.1    Kojima, M.2    Kangawa, K.3
  • 7
    • 35648974703 scopus 로고    scopus 로고
    • Ghrelin and reproduction: Ghrelin as novel regulator of the gonadotropic axis
    • Tena-Sempere M (2008) Ghrelin and reproduction: ghrelin as novel regulator of the gonadotropic axis. Vitam Horm 77: 285-300.
    • (2008) Vitam Horm , vol.77 , pp. 285-300
    • Tena-Sempere, M.1
  • 8
    • 0030732108 scopus 로고    scopus 로고
    • Hypothalamic growth hormone secretagogue-receptor (GHS-R) expression is regulated by growth hormone in the rat
    • Bennett PA, Thomas GB, Howard AD, Feighner SD, van der Ploeg LH, et al. (1997) Hypothalamic growth hormone secretagogue-receptor (GHS-R) expression is regulated by growth hormone in the rat. Endocrinology 138: 4552-4557.
    • (1997) Endocrinology , vol.138 , pp. 4552-4557
    • Bennett, P.A.1    Thomas, G.B.2    Howard, A.D.3    Feighner, S.D.4    van der Ploeg, L.H.5
  • 9
    • 0031765095 scopus 로고    scopus 로고
    • Expression of Growth Hormone Secretagogue- -Receptor in the Mediobasal Hypothalamus
    • Tannenbaum G, Lapointe M, Beaudet A (1998) Expression of Growth Hormone Secretagogue- -Receptor in the Mediobasal Hypothalamus. Endocrinology 139: 4420-4423.
    • (1998) Endocrinology , vol.139 , pp. 4420-4423
    • Tannenbaum, G.1    Lapointe, M.2    Beaudet, A.3
  • 10
    • 0032744366 scopus 로고    scopus 로고
    • Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat
    • Willesen MG, Kristensen P, Rømer J (1999) Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 70: 306-316.
    • (1999) Neuroendocrinology , vol.70 , pp. 306-316
    • Willesen, M.G.1    Kristensen, P.2    Rømer, J.3
  • 11
  • 12
    • 0037456519 scopus 로고    scopus 로고
    • The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    • Cowley MA, Smith RG, Diano S, Tschöp M, Pronchuk N, et al. (2003) The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37: 649-661.
    • (2003) Neuron , vol.37 , pp. 649-661
    • Cowley, M.A.1    Smith, R.G.2    Diano, S.3    Tschöp, M.4    Pronchuk, N.5
  • 13
    • 9044228028 scopus 로고    scopus 로고
    • Mediation by the central nervous system is critical to the in vivo activity of the GH secretagogue L-692,585
    • Hickey GJ, Drisko J, Faidley T, Chang C, Anderson LL, et al. (1996) Mediation by the central nervous system is critical to the in vivo activity of the GH secretagogue L-692,585. J Endocrinol 148: 371-380.
    • (1996) J Endocrinol , vol.148 , pp. 371-380
    • Hickey, G.J.1    Drisko, J.2    Faidley, T.3    Chang, C.4    Anderson, L.L.5
  • 14
    • 0037960962 scopus 로고    scopus 로고
    • Ghrelin Main Action of Growth Hormone Release is Exerted at hypothalamic Level
    • Popovic V, Miljic D, Micic D, Damjanovic S, Arvat E, et al. (2003) Ghrelin Main Action of Growth Hormone Release is Exerted at hypothalamic Level. J Clin Endocrinol Metab 88: 3450-3453.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 3450-3453
    • Popovic, V.1    Miljic, D.2    Micic, D.3    Damjanovic, S.4    Arvat, E.5
  • 15
    • 0028026646 scopus 로고
    • Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep
    • Guillaume V, Magnan E, Cataldi M, Dutour A, Sauze N, et al. (1994) Growth hormone (GH)-releasing hormone secretion is stimulated by a new GH-releasing hexapeptide in sheep. Endocrinology 135: 1073-1076.
    • (1994) Endocrinology , vol.135 , pp. 1073-1076
    • Guillaume, V.1    Magnan, E.2    Cataldi, M.3    Dutour, A.4    Sauze, N.5
  • 16
    • 0031057817 scopus 로고    scopus 로고
    • Induction of c-fos Messenger Ribonucleic Acid in Neuropeptide Y and Growth Hormone (GH)-Releasing Factor Neurons in the Rat Arcuate Nucleus Following Systemic Injection of the GH secretagogue, GH-releasing peptide-6
    • Dickson S, Luckman S (1997) Induction of c-fos Messenger Ribonucleic Acid in Neuropeptide Y and Growth Hormone (GH)-Releasing Factor Neurons in the Rat Arcuate Nucleus Following Systemic Injection of the GH secretagogue, GH-releasing peptide-6. Endocrinology 138: 771-777.
    • (1997) Endocrinology , vol.138 , pp. 771-777
    • Dickson, S.1    Luckman, S.2
  • 17
    • 0031951257 scopus 로고    scopus 로고
    • The nonpeptide growth hormone secretagogue, MK-0677, activates hypothalamic arcuate nucleus neurons in vivo
    • Bailey AR, Smith RG, Leng G (1998) The nonpeptide growth hormone secretagogue, MK-0677, activates hypothalamic arcuate nucleus neurons in vivo. J Neuroendocrinol 10: 111-118.
    • (1998) J Neuroendocrinol , vol.10 , pp. 111-118
    • Bailey, A.R.1    Smith, R.G.2    Leng, G.3
  • 18
    • 0032742765 scopus 로고    scopus 로고
    • GHRP-6-induced changes in electrical activity of single cells in the arcuate, ventromedial and periventricular nucleus neurons of a hypothalamic slice preparation in vitro
    • Hewson AK, Viltart O, McKenzie DN, Dyball RE, Dickson SL (1999) GHRP-6-induced changes in electrical activity of single cells in the arcuate, ventromedial and periventricular nucleus neurons of a hypothalamic slice preparation in vitro. J Neuroendocrinol 11: 919-923.
    • (1999) J Neuroendocrinol , vol.11 , pp. 919-923
    • Hewson, A.K.1    Viltart, O.2    McKenzie, D.N.3    Dyball, R.E.4    Dickson, S.L.5
  • 20
    • 0037382853 scopus 로고    scopus 로고
    • Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin
    • Kohno D, Gao HZ, Muroya S, Kikuyama S, Yada T (2003) Ghrelin directly interacts with neuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes 52: 948-956.
    • (2003) Diabetes , vol.52 , pp. 948-956
    • Kohno, D.1    Gao, H.Z.2    Muroya, S.3    Kikuyama, S.4    Yada, T.5
  • 21
    • 11144349012 scopus 로고    scopus 로고
    • Galanin-like peptide and ghrelin increase cytosolic Ca2+ in neurons containing growth hormonereleasing hormone in the arcuate nucleus
    • Kuramochi M, Kohno D, Onaka T, Kato S, Yada T (2005) Galanin-like peptide and ghrelin increase cytosolic Ca2+ in neurons containing growth hormonereleasing hormone in the arcuate nucleus. Regul Pept 126: 85-89.
    • (2005) Regul Pept , vol.126 , pp. 85-89
    • Kuramochi, M.1    Kohno, D.2    Onaka, T.3    Kato, S.4    Yada, T.5
  • 22
    • 33947098380 scopus 로고    scopus 로고
    • Role of endogenous ghrelin in growth hormone secretion, appetite regulation and metabolism
    • Dimaraki EV, Jaffe CA (2006) Role of endogenous ghrelin in growth hormone secretion, appetite regulation and metabolism. Rev Endocr Metab Disord 7: 237-29.
    • (2006) Rev Endocr Metab Disord , vol.7 , pp. 237-329
    • Dimaraki, E.V.1    Jaffe, C.A.2
  • 23
    • 2542475178 scopus 로고    scopus 로고
    • Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein
    • Chen HY, Trumbauer ME, Chen AS, Weingarth DT, Adams JR, et al. (2004) Orexigenic action of peripheral ghrelin is mediated by neuropeptide Y and agouti-related protein. Endocrinology 145: 2607-2612.
    • (2004) Endocrinology , vol.145 , pp. 2607-2612
    • Chen, H.Y.1    Trumbauer, M.E.2    Chen, A.S.3    Weingarth, D.T.4    Adams, J.R.5
  • 24
    • 50249120768 scopus 로고    scopus 로고
    • Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
    • Tong Q, Ye CP, Jones JE, Elmquist JK, Lowell BB (2008) Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci 11: 998-1000.
    • (2008) Nat Neurosci , vol.11 , pp. 998-1000
    • Tong, Q.1    Ye, C.P.2    Jones, J.E.3    Elmquist, J.K.4    Lowell, B.B.5
  • 25
    • 34249791214 scopus 로고    scopus 로고
    • Fasting inhibits the growth and reproductive axes via distinct Y2 and Y4 receptor-mediated pathways
    • Lin S, Lin EJ, Boey D, Lee NJ, Slack K, et al. (2007) Fasting inhibits the growth and reproductive axes via distinct Y2 and Y4 receptor-mediated pathways. Endocrinology 148: 2056-2065.
    • (2007) Endocrinology , vol.148 , pp. 2056-2065
    • Lin, S.1    Lin, E.J.2    Boey, D.3    Lee, N.J.4    Slack, K.5
  • 26
    • 33845874695 scopus 로고    scopus 로고
    • Severity of the catabolic condition differentially modulates hypothalamic expression of growth hormone-releasing hormone in the fasted mouse: Potential role of neuropeptide Y and corticotropin-releasing hormone
    • Luque RM, Park S, Kineman RD (2007) Severity of the catabolic condition differentially modulates hypothalamic expression of growth hormone-releasing hormone in the fasted mouse: potential role of neuropeptide Y and corticotropin-releasing hormone. Endocrinology 148: 300-309.
    • (2007) Endocrinology , vol.148 , pp. 300-309
    • Luque, R.M.1    Park, S.2    Kineman, R.D.3
  • 27
    • 33847145032 scopus 로고    scopus 로고
    • Dual-level afferent control of growth hormone-releasing hormone (GHRH) neurons in GHRH-green fluorescent protein transgenic mice
    • Baccam N, Alonso G, Costecalde T, Fontanaud P, Molino F, et al. (2007) Dual-level afferent control of growth hormone-releasing hormone (GHRH) neurons in GHRH-green fluorescent protein transgenic mice. J Neuroscience 27: 1631-1641.
    • (2007) J Neuroscience , vol.27 , pp. 1631-1641
    • Baccam, N.1    Alonso, G.2    Costecalde, T.3    Fontanaud, P.4    Molino, F.5
  • 28
    • 0037508542 scopus 로고    scopus 로고
    • Growth hormone-releasing hormone (GHRH) neurons in GHRH-enhanced green fluorescent protein transgenic mice: A ventral hypothalamic network
    • Balthasar N, Méry PF, Magoulas CB, Mathers KE, Martin A, et al. (2003) Growth hormone-releasing hormone (GHRH) neurons in GHRH-enhanced green fluorescent protein transgenic mice: a ventral hypothalamic network. Endocrinology 144: 2728-2740.
    • (2003) Endocrinology , vol.144 , pp. 2728-2740
    • Balthasar, N.1    Méry, P.F.2    Magoulas, C.B.3    Mathers, K.E.4    Martin, A.5
  • 29
    • 33947387971 scopus 로고    scopus 로고
    • Selective alteration at the growth-hormone- releasing-hormone nerve terminals during aging in GHRH-green fluorescent protein mice
    • Alonso G, Sanchez-Hormigo A, Loudes C, El Yandouzi T, Carmignac D, et al. (2007) Selective alteration at the growth-hormone- releasing-hormone nerve terminals during aging in GHRH-green fluorescent protein mice. Aging Cell 6: 197-207.
    • (2007) Aging Cell , vol.6 , pp. 197-207
    • Alonso, G.1    Sanchez-Hormigo, A.2    Loudes, C.3    El Yandouzi, T.4    Carmignac, D.5
  • 30
    • 0036733916 scopus 로고    scopus 로고
    • EP1572: A novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man
    • Broglio F, Boutignon F, Benso A, Gottero C, Prodam F, et al. (2002) EP1572: a novel peptido-mimetic GH secretagogue with potent and selective GH-releasing activity in man. J Endocrinol Invest 25: RC26-RC28.
    • (2002) J Endocrinol Invest , vol.25
    • Broglio, F.1    Boutignon, F.2    Benso, A.3    Gottero, C.4    Prodam, F.5
  • 31
    • 36148975300 scopus 로고    scopus 로고
    • Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations
    • Moulin A, Demange L, Bergé G, Gagne D, Ryan J, et al. (2007) Toward potent ghrelin receptor ligands based on trisubstituted 1,2,4-triazole structure. 2. Synthesis and pharmacological in vitro and in vivo evaluations. J Med Chem 50: 5790-5806.
    • (2007) J Med Chem , vol.50 , pp. 5790-5806
    • Moulin, A.1    Demange, L.2    Bergé, G.3    Gagne, D.4    Ryan, J.5
  • 33
    • 39149128278 scopus 로고    scopus 로고
    • New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations
    • Moulin A, Demange L, Ryan J, Mousseaux D, Sanchez P, et al. (2008) New trisubstituted 1,2,4-triazole derivatives as potent ghrelin receptor antagonists. 3. Synthesis and pharmacological in vitro and in vivo evaluations. J Med Chem 51: 689-693.
    • (2008) J Med Chem , vol.51 , pp. 689-693
    • Moulin, A.1    Demange, L.2    Ryan, J.3    Mousseaux, D.4    Sanchez, P.5
  • 34
    • 0032985009 scopus 로고    scopus 로고
    • Growth hormone-releasing hormone receptor (GHRH-R) and growth hormone secretagogue receptor (GHS-R) mRNA levels during postnatal development in male and female rats
    • Kamegai J, Wakabayashi I, Kineman RD, Frohman LA (1999) Growth hormone-releasing hormone receptor (GHRH-R) and growth hormone secretagogue receptor (GHS-R) mRNA levels during postnatal development in male and female rats. J Neuroendocrinol 11: 299-306.
    • (1999) J Neuroendocrinol , vol.11 , pp. 299-306
    • Kamegai, J.1    Wakabayashi, I.2    Kineman, R.D.3    Frohman, L.A.4
  • 35
    • 0034502899 scopus 로고    scopus 로고
    • Developmentally and regionally regulated expression of growth hormone secretagogue receptor mRNA in rat brain and pituitary gland
    • Katayama M, Nogami H, Nishiyama J, Kawase T, Kawamura K (2000) Developmentally and regionally regulated expression of growth hormone secretagogue receptor mRNA in rat brain and pituitary gland. Neuroendocrinology 72: 333-340.
    • (2000) Neuroendocrinology , vol.72 , pp. 333-340
    • Katayama, M.1    Nogami, H.2    Nishiyama, J.3    Kawase, T.4    Kawamura, K.5
  • 36
    • 33847081784 scopus 로고    scopus 로고
    • Ghrelin and growth hormone secretagogue receptor expression in mice during aging
    • Sun Y, Garcia JM, Smith RG (2007) Ghrelin and growth hormone secretagogue receptor expression in mice during aging. Endocrinology 148: 1323-1329.
    • (2007) Endocrinology , vol.148 , pp. 1323-1329
    • Sun, Y.1    Garcia, J.M.2    Smith, R.G.3
  • 37
    • 34548436635 scopus 로고    scopus 로고
    • Ghrelin uses Galphai2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet beta-cells: Novel signal transduction of ghrelin
    • Dezaki K, Kakei M, Yada T (2007) Ghrelin uses Galphai2 and activates voltage-dependent K+ channels to attenuate glucose-induced Ca2+ signaling and insulin release in islet beta-cells: novel signal transduction of ghrelin. Diabetes 56: 2319-27.
    • (2007) Diabetes , vol.56 , pp. 2319-2327
    • Dezaki, K.1    Kakei, M.2    Yada, T.3
  • 38
    • 0028842290 scopus 로고
    • Effects of the phospholipase-C inhibitor, U73122, on signaling and secretion in pituitary gonadotrophs
    • Zheng L, Paik WY, Cesnjaj M, Balla T, Tomić M, et al. (1995) Effects of the phospholipase-C inhibitor, U73122, on signaling and secretion in pituitary gonadotrophs. Endocrinology 136: 1079-88.
    • (1995) Endocrinology , vol.136 , pp. 1079-1088
    • Zheng, L.1    Paik, W.Y.2    Cesnjaj, M.3    Balla, T.4    Tomić, M.5
  • 39
    • 33744485247 scopus 로고    scopus 로고
    • Regulation of ERK1/2 activity by ghrelin-activated growth hormone secretagogue receptor 1A involves a PLC/PKC epsilon pathway
    • Mousseaux D, Le Gallic L, Ryan J, Oiry C, Gagne D, et al. (2006) Regulation of ERK1/2 activity by ghrelin-activated growth hormone secretagogue receptor 1A involves a PLC/PKC epsilon pathway. Br J Pharmacol 148: 350-65.
    • (2006) Br J Pharmacol , vol.148 , pp. 350-365
    • Mousseaux, D.1    Le Gallic, L.2    Ryan, J.3    Oiry, C.4    Gagne, D.5
  • 40
    • 50449087725 scopus 로고    scopus 로고
    • Kisspeptin excites gonadotropin- releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels
    • Liu X, Lee K, Herbison AE (2008) Kisspeptin excites gonadotropin- releasing hormone neurons through a phospholipase C/calcium-dependent pathway regulating multiple ion channels. Endocrinology 149: 4605-14.
    • (2008) Endocrinology , vol.149 , pp. 4605-4614
    • Liu, X.1    Lee, K.2    Herbison, A.E.3
  • 41
    • 0032823244 scopus 로고    scopus 로고
    • The effect of GHRP-6 on the intracellular Na+ concentration of rat pituitary cells in primary culture
    • Kato M, Sakuma Y (1999) The effect of GHRP-6 on the intracellular Na+ concentration of rat pituitary cells in primary culture. J Neuroendocrinol 11: 795-800.
    • (1999) J Neuroendocrinol , vol.11 , pp. 795-800
    • Kato, M.1    Sakuma, Y.2
  • 42
    • 49649122302 scopus 로고    scopus 로고
    • UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals
    • Andrews ZB, Liu ZW, Walllingford N, Erion DM, Borok E, et al. (2008) UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals. Nature 454: 846-51.
    • (2008) Nature , vol.454 , pp. 846-851
    • Andrews, Z.B.1    Liu, Z.W.2    Walllingford, N.3    Erion, D.M.4    Borok, E.5
  • 44
    • 36248983762 scopus 로고    scopus 로고
    • Calcium-dependent fast depolarizing afterpotentials in vasopressin neurons in the rat supraoptic nucleus
    • Teruyama R, Armstrong WE (2007) Calcium-dependent fast depolarizing afterpotentials in vasopressin neurons in the rat supraoptic nucleus. J Neurophysiol 98: 2612-21.
    • (2007) J Neurophysiol , vol.98 , pp. 2612-2621
    • Teruyama, R.1    Armstrong, W.E.2
  • 45
    • 0036595607 scopus 로고    scopus 로고
    • Inhibition of transiently expressed low- and high-voltage-activated calcium channels by trivalent metal cations
    • Beedle AM, Hamid J, Zamponi GW (2002) Inhibition of transiently expressed low- and high-voltage-activated calcium channels by trivalent metal cations. J Membr Biol 187: 225-38.
    • (2002) J Membr Biol , vol.187 , pp. 225-238
    • Beedle, A.M.1    Hamid, J.2    Zamponi, G.W.3
  • 46
    • 0023518468 scopus 로고
    • Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones
    • Fox AP, Nowycky MC, Tsien RW (1987) Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones. J Physiol 394: 149-72.
    • (1987) J Physiol , vol.394 , pp. 149-172
    • Fox, A.P.1    Nowycky, M.C.2    Tsien, R.W.3
  • 47
    • 0034968209 scopus 로고    scopus 로고
    • Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth
    • Low MJ, Otero-Corchon V, Parlow AF, Ramirez JL, Kumar U, et al. (2001) Somatostatin is required for masculinization of growth hormone-regulated hepatic gene expression but not of somatic growth. J Clin Invest 107: 1571-1580.
    • (2001) J Clin Invest , vol.107 , pp. 1571-1580
    • Low, M.J.1    Otero-Corchon, V.2    Parlow, A.F.3    Ramirez, J.L.4    Kumar, U.5
  • 48
    • 0034640334 scopus 로고    scopus 로고
    • Effect of a selective neuropeptide Y Y(2) receptor antagonist, BIIE0246 on neuropeptide Y release
    • King PJ, Williams G, Doods H, Widdowson PS (2000) Effect of a selective neuropeptide Y Y(2) receptor antagonist, BIIE0246 on neuropeptide Y release. Eur J Pharmacol 396: R1-R3.
    • (2000) Eur J Pharmacol , vol.396
    • King, P.J.1    Williams, G.2    Doods, H.3    Widdowson, P.S.4
  • 49
    • 34250818029 scopus 로고    scopus 로고
    • NKCC1 phosphorylation stimulates neurite growth of injured adult sensory neurons
    • Pieraut S, Laurent-Matha V, Sar C, Hubert T, Méchaly I, et al. (2007) NKCC1 phosphorylation stimulates neurite growth of injured adult sensory neurons. J Neuroscience 27: 6751-6759.
    • (2007) J Neuroscience , vol.27 , pp. 6751-6759
    • Pieraut, S.1    Laurent-Matha, V.2    Sar, C.3    Hubert, T.4    Méchaly, I.5
  • 50
    • 1642464956 scopus 로고    scopus 로고
    • Physiological studies of transgenic mice overexpressing growth hormone (GH) secretagogue receptor 1A in GH-releasing hormone neurons
    • Lall S, Balthasar N, Carmignac D, Magoulas C, Sesay A, et al. (2004) Physiological studies of transgenic mice overexpressing growth hormone (GH) secretagogue receptor 1A in GH-releasing hormone neurons. Endocrinology 145: 1602-1611.
    • (2004) Endocrinology , vol.145 , pp. 1602-1611
    • Lall, S.1    Balthasar, N.2    Carmignac, D.3    Magoulas, C.4    Sesay, A.5
  • 51
    • 0037382853 scopus 로고    scopus 로고
    • Ghrelin directly interacts withneuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin
    • Kohno D, Gao HZ, Muroya S, Kikuyama S, Yada T (2003) Ghrelin directly interacts withneuropeptide-Y-containing neurons in the rat arcuate nucleus: Ca2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes 52: 948-56.
    • (2003) Diabetes , vol.52 , pp. 948-956
    • Kohno, D.1    Gao, H.Z.2    Muroya, S.3    Kikuyama, S.4    Yada, T.5
  • 52
    • 0344407033 scopus 로고    scopus 로고
    • Site-specific effects of ghrelin on the neuronal activity in the hypothalamic arcuate nucleus
    • Riediger T, Traebert M, Schmid HA, Scheel C, Lutz TA, et al. (2003) Site-specific effects of ghrelin on the neuronal activity in the hypothalamic arcuate nucleus. Neurosci Lett 341: 151-155.
    • (2003) Neurosci Lett , vol.341 , pp. 151-155
    • Riediger, T.1    Traebert, M.2    Schmid, H.A.3    Scheel, C.4    Lutz, T.A.5
  • 53
    • 43049127762 scopus 로고    scopus 로고
    • Effects of ghrelin on neuronal activity in the ventromedial nucleus of the hypothalamus in infantile rats: An in vitro study
    • Yanagida H, Morita T, Kim J, Yoshida K, Nakajima K, et al. (2008) Effects of ghrelin on neuronal activity in the ventromedial nucleus of the hypothalamus in infantile rats: an in vitro study. Peptides 29: 912-918.
    • (2008) Peptides , vol.29 , pp. 912-918
    • Yanagida, H.1    Morita, T.2    Kim, J.3    Yoshida, K.4    Nakajima, K.5
  • 54
    • 34249051111 scopus 로고    scopus 로고
    • Calcium homeostasis and modulation of synaptic plasticity in the aged brain
    • Foster TC (2007) Calcium homeostasis and modulation of synaptic plasticity in the aged brain. Aging Cell 6: 319-25.
    • (2007) Aging Cell , vol.6 , pp. 319-325
    • Foster, T.C.1
  • 55
    • 0027303617 scopus 로고
    • Growth hormone release evoked by electrical stimulation of the arcuate nucleus in anesthetized male rats
    • Dickson SL, Leng G, Robinson ICAF (1993) Growth hormone release evoked by electrical stimulation of the arcuate nucleus in anesthetized male rats. Brain Res 623: 95-100.
    • (1993) Brain Res , vol.623 , pp. 95-100
    • Dickson, S.L.1    Leng, G.2    Robinson, I.C.A.F.3
  • 56
    • 33344479006 scopus 로고    scopus 로고
    • Ghrelin controls hippocampal spine synapse density and memory performance
    • Diano S, Farr SA, Benoit SC, McNay EC, da Silva I, et al. (2006) Ghrelin controls hippocampal spine synapse density and memory performance. Nat Neurosci 9: 381-388.
    • (2006) Nat Neurosci , vol.9 , pp. 381-388
    • Diano, S.1    Farr, S.A.2    Benoit, S.C.3    McNay, E.C.4    da Silva, I.5
  • 57
    • 54149094094 scopus 로고    scopus 로고
    • Effects of triglycerides, obesity, and starvation on ghrelin transport across the blood-brain barrier
    • Banks WA, Burney BO, Robinson SM (2008) Effects of triglycerides, obesity, and starvation on ghrelin transport across the blood-brain barrier. Peptides 29: 2061-2065.
    • (2008) Peptides , vol.29 , pp. 2061-2065
    • Banks, W.A.1    Burney, B.O.2    Robinson, S.M.3
  • 58
    • 0033784980 scopus 로고    scopus 로고
    • Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats
    • Hewson AK, Dickson SL (2000) Systemic administration of ghrelin induces Fos and Egr-1 proteins in the hypothalamic arcuate nucleus of fasted and fed rats. J Neuroendocrinol 12: 1047-1049.
    • (2000) J Neuroendocrinol , vol.12 , pp. 1047-1049
    • Hewson, A.K.1    Dickson, S.L.2
  • 59
    • 9444246501 scopus 로고    scopus 로고
    • A receptor in pituitary and hypothalamus that functions in growth hormone release
    • Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, et al. (1996) A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 273: 974-977.
    • (1996) Science , vol.273 , pp. 974-977
    • Howard, A.D.1    Feighner, S.D.2    Cully, D.F.3    Arena, J.P.4    Liberator, P.A.5
  • 60
    • 0033540056 scopus 로고    scopus 로고
    • Ghrelin is a growth-hormone-releasing acylated peptide from stomach
    • Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, et al. (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature London 402: 656-660.
    • (1999) Nature London , vol.402 , pp. 656-660
    • Kojima, M.1    Hosoda, H.2    Date, Y.3    Nakazato, M.4    Matsuo, H.5
  • 62
    • 9944222423 scopus 로고    scopus 로고
    • The effect of agouti-related protein on growth hormone secretion in adult male rats
    • Tamura H, Kamegai J, Shimizu T, Ishii S, Sugihara H, et al. (2005) The effect of agouti-related protein on growth hormone secretion in adult male rats. Regul Pept 125: 145-149.
    • (2005) Regul Pept , vol.125 , pp. 145-149
    • Tamura, H.1    Kamegai, J.2    Shimizu, T.3    Ishii, S.4    Sugihara, H.5
  • 63
    • 0037187322 scopus 로고    scopus 로고
    • Ghrelin gene expression is age-dependent and influenced by gender and the level of circulating IGF-I
    • Liu YL, Yakar S, Otero-Corchon V, Low MJ, Liu JL (2002) Ghrelin gene expression is age-dependent and influenced by gender and the level of circulating IGF-I. Mol Cell Endocrinol 189: 97-103.
    • (2002) Mol Cell Endocrinol , vol.189 , pp. 97-103
    • Liu, Y.L.1    Yakar, S.2    Otero-Corchon, V.3    Low, M.J.4    Liu, J.L.5
  • 64
    • 0036106519 scopus 로고    scopus 로고
    • Ghrelin in neonatal rats: Distribution in stomach and its possible role
    • Hayashida T, Nakahara K, Mondal MS, Date Y, Nakazato M, et al. (2002) Ghrelin in neonatal rats: distribution in stomach and its possible role. J Endocrinol 173: 239-245.
    • (2002) J Endocrinol , vol.173 , pp. 239-245
    • Hayashida, T.1    Nakahara, K.2    Mondal, M.S.3    Date, Y.4    Nakazato, M.5
  • 65
    • 0037221584 scopus 로고    scopus 로고
    • Role of ghrelin in the control of growth hormone secretion in prepubertal rats: Interactions with excitatory amino acids
    • Pinilla L, Barreiro ML, Tena-Sempere M, Aguilar E (2003) Role of ghrelin in the control of growth hormone secretion in prepubertal rats: interactions with excitatory amino acids. Neuroendocrinology 77: 83-90.
    • (2003) Neuroendocrinology , vol.77 , pp. 83-90
    • Pinilla, L.1    Barreiro, M.L.2    Tena-Sempere, M.3    Aguilar, E.4
  • 66
    • 0033378508 scopus 로고    scopus 로고
    • Neuropeptide Y induced inhibition of noradrenaline release in rat hypothalamus: Role of receptor subtype and nitric oxide
    • Bitran M, Tapia W, Eugenín E, Orio P, Boric MP (1999) Neuropeptide Y induced inhibition of noradrenaline release in rat hypothalamus: role of receptor subtype and nitric oxide. Brain Res 851: 87-93.
    • (1999) Brain Res , vol.851 , pp. 87-93
    • Bitran, M.1    Tapia, W.2    Eugenín, E.3    Orio, P.4    Boric, M.P.5
  • 67
    • 0032852850 scopus 로고    scopus 로고
    • Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: Further evidence for a role of nitric oxide in feeding
    • Morley JE, Alshaher MM, Farr SA, Flood JF, Kumar VB (1999) Leptin and neuropeptide Y (NPY) modulate nitric oxide synthase: further evidence for a role of nitric oxide in feeding. Peptides 20: 595-600.
    • (1999) Peptides , vol.20 , pp. 595-600
    • Morley, J.E.1    Alshaher, M.M.2    Farr, S.A.3    Flood, J.F.4    Kumar, V.B.5
  • 68
    • 0041929602 scopus 로고    scopus 로고
    • Ghrelin-induced feeding is dependent on nitric oxide
    • Gaskin FS, Farr SA, Banks WA, Kumar VB, et al. (2003) Ghrelin-induced feeding is dependent on nitric oxide. Peptides 24: 913-918.
    • (2003) Peptides , vol.24 , pp. 913-918
    • Gaskin, F.S.1    Farr, S.A.2    Banks, W.A.3    Kumar, V.B.4
  • 70
    • 33751547882 scopus 로고    scopus 로고
    • Nitric oxide directly inhibits ghrelin-activated neurons of the arcuate nucleus
    • Riediger T, Giannini P, Erguven E, Lutz T (2006) Nitric oxide directly inhibits ghrelin-activated neurons of the arcuate nucleus. Brain Res 1125: 37-45.
    • (2006) Brain Res , vol.1125 , pp. 37-45
    • Riediger, T.1    Giannini, P.2    Erguven, E.3    Lutz, T.4
  • 71
    • 33745008298 scopus 로고
    • On the Estimation of the Intensity Function of a Stationary Point Process
    • Cox DR (1965) On the Estimation of the Intensity Function of a Stationary Point Process. J Royal Statistical Soc Series B 27: 332-337.
    • (1965) J Royal Statistical Soc Series B , vol.27 , pp. 332-337
    • Cox, D.R.1
  • 72
    • 0003281213 scopus 로고
    • Estimation of the Second-Order Intensities of a Bivariate Stationary Point Process
    • Brillinger D (1976) Estimation of the Second-Order Intensities of a Bivariate Stationary Point Process. Journal of the Royal Statistical Society Series B 38: 60-66.
    • (1976) Journal of the Royal Statistical Society Series B , vol.38 , pp. 60-66
    • Brillinger, D.1


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