Case 7-2010: A 49-year-old man with peripheral neuropathy and ascites

New England Journal of Medicine

Volumn 362, Issue 10, 2010, Pages 929-940

  Ropper, Allan H ^a,b   Raje, Noopur S ^b   Lawrimore, Tara M ^b   Camelo Piragua, Sandra ^b,c   Sohani, Aliyah R ^b,c  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AZATHIOPRINE; FUROSEMIDE; GABAPENTIN; IMMUNOGLOBULIN;

ADULT; ARTICLE; ASCITES; CASE REPORT; CEREBROSPINAL FLUID ANALYSIS; CHRONIC INFLAMMATORY DEMYELINATING POLYNEUROPATHY; COMPUTER ASSISTED TOMOGRAPHY; DIFFERENTIAL DIAGNOSIS; DRUG WITHDRAWAL; ELECTROMYOGRAM; GASTROCNEMIUS MUSCLE; HUMAN; KIDNEY FUNCTION TEST; LABORATORY TEST; LIVER FUNCTION TEST; MALE; MOTOR PERFORMANCE; NERVE CONDUCTION; NUCLEAR MAGNETIC RESONANCE IMAGING; PERCEPTION; PERIPHERAL NEUROPATHY; PLASMAPHERESIS; POEMS SYNDROME; PRIORITY JOURNAL; RESPIRATORY FUNCTION; SENSORY SYSTEM; SURAL NERVE; VIBRATION; VISION; BONE TUMOR; BRACHIAL PLEXUS; CLINICAL OBSERVATION; CLINICAL STUDY; DEMYELINATING DISEASE; DIAGNOSIS; LUNG FUNCTION TEST; MIDDLE AGED; PATHOLOGY; PLASMACYTOMA; SACRUM;

ASCITES; BONE NEOPLASMS; BRACHIAL PLEXUS; DEMYELINATING DISEASES; DIAGNOSIS, DIFFERENTIAL; HUMANS; MALE; MIDDLE AGED; PERIPHERAL NERVOUS SYSTEM DISEASES; PLASMACYTOMA; POEMS SYNDROME; RESPIRATORY FUNCTION TESTS; SACRUM; TOMOGRAPHY, X-RAY COMPUTED;

EID: 77949364564     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMcpc0907805     Document Type: Article

References (23)

1. Crow RS. Peripheral neuritis in myelomatosis. Br Med J 1956;2:802-4.
2. Fukase M, Kakimatsu T, Nishitani H, et al. Report of a case of solitary plasmacytoma in the abdomen presenting with polyneuropathy, and endocrinologic disorders. Clin Neurol 1969;9:657. abstract.
3. Bardwick PA, Zvaifler NJ, Gill GN, Newman D, Greenway GD, Resnick DL. Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: the POEMS syndrome: report on two cases and a review of the literature. Medicine (Baltimore) 1980;59:311-22.
4. Dispenzieri A. POEMS syndrome. Blood Rev 2007;21:285-99.
5. Higuchi M, Kamijo H, Koyama T, et al. POEMS syndrome caused refractory ascites in a polycystic disease patient undergoing hemodialysis. Clin Exp Nephrol 2003;7:301-5.
6. Loeb JM, Hauger PH, Carney JD, Cooper AD. Refractory ascites due to POEMS syndrome. Gastroenterology 1989;96: 247-9.
7. Dispenzieri A, Kyle RA, Lacy MQ, et al. POEMS syndrome: definitions and long-term outcome. Blood 2003;101:2496-506.
8. Miralles GD, O'Fallon JR, Talley NJ. Plasma-cell dyscrasia with polyneuropathy: the spectrum of POEMS syndrome. N Engl J Med 1992;327:1919-23.
9. Nakanishi T, Sobue I, Toyokura Y, et al. The Crow-Fukase syndrome: a study of 102 cases in Japan. Neurology 1984;34: 712-20.
10. Hashiguchi T, Arimura K, Matsumuro K, et al. Highly concentrated vascular endothelial growth factor in platelets in Crow-Fukase syndrome. Muscle Nerve 2000;23:1051-6.
11. Watanabe O, Maruyama I, Arimura K, et al. Overproduction of vascular endothelial growth factor/vascular permeability factor is causative in Crow-Fukase (POEMS) syndrome. Muscle Nerve 1998; 21:1390-7.
12. Ropper AH, Gorson KC, Gooch CL, et al. Vascular endothelial growth factor gene transfer for diabetic polyneuropathy: a randomized, double-blinded trial. Ann Neurol 2009;65:386-93.
13. Bélec L, Mohamed AS, Authier FJ, et al. Human herpesvirus 8 infection in patients with POEMS syndrome-associated multicentric Castleman's disease. Blood 1999;93:3643-53.
14. Feinberg L, Temple D, de Marchena E, Patarca R, Mitrani A. Soluble immune mediators in POEMS syndrome with pulmonary hypertension: case report and review of the literature. Crit Rev Oncog 1999;10: 293-302.
15. Watanabe O, Arimura K, Kitajima I, Osame M, Maruyama I. Greatly raised vascular endothelial growth factor (VEGF) in POEMS syndrome. Lancet 1996;347:702.
16. Abe D, Nakaseko C, Takeuchi M, et al. Restrictive usage of monoclonal immunoglobulin lambda light chain germline in POEMS syndrome. Blood 2008;112:836-9.
17. Soubrier M, Labauge P, Jouanel P, Viallard JL, Piette JC, Sauvezie B. Restricted use of Vλ genes in POEMS syndrome. Haematologica 2004;89(4):e4-e5.
18. Dispenzieri A, Kyle RA, Lacy MQ, et al. Superior survival in primary systemic amyloidosis patients undergoing peripheral blood stem cell transplantation: a case-control study. Blood 2004;103:3960-3.
19. Dispenzieri A, Moreno-Aspitia A, Suarez GA, et al. Peripheral blood stem cell transplantation in 16 patients with POEMS syndrome, and a review of the literature. Blood 2004;104:3400-7.
20. Badros A, Porter N, Zimrin A. Bevacizumab therapy for POEMS syndrome. Blood 2005;106:1135.
21. Dietrich PY, Duchosal MA. Bevacizumab therapy before autologous stem-cell transplantation for POEMS syndrome. Ann Oncol 2008;19:595.
22. Dispenzieri A, Klein CJ, Mauermann ML. Lenalidomide therapy in a patient with POEMS syndrome. Blood 2007;110:1075-6.
23. Kuwabara S, Misawa S, Kanai K, et al. Thalidomide reduces serum VEGF levels and improves peripheral neuropathy in POEMS syndrome. J Neurol Neurosurg Psychiatry 2008;79:1255-7.