Penetration of enrofloxacin into the nasal secretions and relationship between nasal secretions and plasma enrofloxacin concentrations after intramuscular administration in healthy pigs

Journal of Veterinary Pharmacology and Therapeutics

Volumn 33, Issue 2, 2010, Pages 183-188

  Bimazubute, M ^a   Cambier, C ^b   Baert, K ^c   Vanbelle, S ^a   Chiap, P ^d   Albert, A ^a   Delporte, J P ^a   Gustin, P ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b Pharnimal Sprl ^*  (Belgium)

^c GHENT UNIVERSITY   (Belgium)

^d UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; ENROFLOXACIN;

ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG HALF LIFE; HALF LIFE TIME; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; NOSE SECRETION; PREDICTION; PRIORITY JOURNAL; SWINE;

ANIMALS; ANTI-BACTERIAL AGENTS; AREA UNDER CURVE; FEMALE; FLUOROQUINOLONES; HALF-LIFE; INJECTIONS, INTRAMUSCULAR; MALE; MUCUS; NASAL MUCOSA; SWINE;

ANIMALIA; SUIDAE;

EID: 77949349014     PISSN: 01407783     EISSN: 13652885     Source Type: Journal    
DOI: 10.1111/j.1365-2885.2009.01123.x     Document Type: Article

References (20)

1. Aarestrup, F.M., Oliver Duran, C. & Burch, D.G.S. (2008) Antimicrobial resistance in swine production. Animal Health Research Reviews, 9, 135-148.
2. Agersø, H. & Friis, C. (1998) Penetration of amoxycillin into the respiratory tract tissues and secretions in pigs. Research in Veterinary Sciences, 64, 245-250.
3. Anadón, A., Martinez-Larrañaga, M.R., Diaz, M.J., Fernandez, R., Martinez, M.A. & Fernandez, M.C. (1995) Pharmacokinetics and tissue residues of norfloxacin and its N-desethyl- and oxo-metabolites in healthy pigs. Journal of Veterinary Pharmacology and Therapeutics, 18, 220-225.
4. Anadón, A., Martínez-Larrañaga, M.R., Díaz, M.J., Fernández-Cruz, M.L., Martínez, M.A., Frejo, M.T., Mart́nez, M., Iturbe, J. & Tafur, M. (1999) Pharmacokinetic variables and tissue residues of enrofloxacin and ciprofloxacin in healthy pigs. American Journal of Veterinary Research, 60, 1377-1382.
5. Bimazubute, M., Rozet, E., Dizier, I., Gustin, P., Hubert, P., Crommen, J. & Chiap, P. (2008) Liquid chromatographic determination of enrofloxacin in nasal secretions and plasma of healthy pigs using restricted access material for on-line sample clean-up. Journal of Chromatography. A., 1189, 456-466.
6. Cox, S.K., Cottrell, M.B., Smith, L., Papich, M.G., Frazier, D.L. & Bartges, J. (2004) Allometric analysis of ciprofloxacin and enrofloxacin pharmacokinetics across species. Journal of Veterinary Pharmacology and Therapeutics, 27, 139-146.
7. Davis, J.L., Foster, D.M. & Papich, M.G. (2007) Pharmacokinetics and tissue distribution of enrfloxacin and its active metabolite ciprofloxacin in calves. Journal of Veterinary Pharmacology and Therapeutics, 30, 564-571.
8. Friis, C. (1993) Penetration of danofloxacin into the respiratory tract tissues and secretions in calves. American Journal of Veterinary Research, 54, 1122-1127.
9. Kadlec, K., Kehrenberg, C., Wallmann, J. & Schwarz, S. (2004) Antimicrobial susceptibility of Bordetella bronchiseptica isolates from porcine respiratory tract infections. Antimicrobial agents and Chemotherapy, 48, 4903-4906.
10. Küng, K., Riond, J.L. & Wanner, M. (1993) Pharmacokinetics of enrofloxacin and its metabolite ciprofloxacin after intravenous and oral administration of enrofloxacin in dogs. Journal of Veterinary Pharmacology and Therapeutics, 16, 462-468.
11. Lizarazo, Y.A., Ferri, E.F., de la Fuente, A.J. & Martín, C.B. (2006) Evaluation of changes in antimicrobial susceptibility patterns of Pasteurella multocida subsp multocida isolates from pigs in Spain in 1987-1988 and 2003-2004. American Journal of Veterinary Research, 67, 663-668.
12. Papich, M.G. & Rivière, J.E. (2001) Fluoroquinolone antimicrobial drugs. In Veterinary Pharmacology and Therapeutics, 8th edn. Ed. Adams, R., Chapter 45, pp. 898-917. Iowa State University Press, Ames.
13. Pijpers, A., Heinen, E., De Jong, A. & Verheijden, J.H.M. (1997) Enrofloxacin pharmacokinetics after intravenous and intramuscular administration in pig. Journal of Veterinary Pharmacology and Therapeutics, 20, 42-43.
14. Post, L.O., Cope, C.V., Farrell, D.E., Baker, J.D. & Myers, M.J. (2002) Influence of porcine Actinobacillus pleuropneumoniae infection and dexamethasone on the pharmacokinetic parameters of enrofloxacin. The Journal of Pharmacology and Experimental Therapeutics, 301, 217-222.
15. Richez, P., Pedersen Mörner, A., De Jong, A. & Monlouis, J.D. (1997) Plasma pharmacokinetics of parenterally administered danofloxacin and enrofloxacin in pigs. Journal of Veterinary Pharmacology and Therapeutics, 20, 41-42.
16. Villa, R., Prandini, E., Caloni, F. & Carli, S. (1997) Serum protein binding of some sulfonamides, quinolones and fluoroquinolones in farm and domestic animals. Journal of Veterinary Pharmacology and Therapeutics, 20 (Suppl. 1), 34-35.
17. Walker, R.D. & Dowling, P.M. (2006) Fluoroquinolones. In Antimicrobial Therapy in Veterinary Medicine, 4th edn. Eds Giguère, S., Prescott, J.F., Baggot, J.D., Walker, R.D. & Dowling, P.M., Chapter 17, pp. 263-284. Iowa State University Press, Ames.
18. Wallmann, J., Kaspar, H. & Kroker, R. (2004) Data on the prevalence of antimicrobial susceptibility of veterinary pathogens from cattle and pigs: national antibiotic resistance monitoring 2002 ? 2003 of the BVL (Bundesamt für Verbraucherschutz und Lebensmittelsicherheit, Berlin). Berliner und Münchener Tierärztliche Wochenschrift, 117, 480-492.
19. Wiuff, C., Lykkesfeldt, J., Aarestrup, F.M. & Svendsen, O. (2002) Distribution of enrofloxacin in intestinal tissue and contents of healthy pigs after oral and intramuscular administrations. Journal of Veterinary Pharmacology and Therapeutics, 25, 335-342.
20. Zeng, Z. & Fung, K. (1997) Effects of experimentally induced Escherichia coli infection on the pharmacokinetics of enrofloxacin in pigs. Journal of Veterinary Pharmacology and Therapeutics, 20 (Suppl. 1), 39.