C/EBPβ Is a Major Regulatory Element Driving Transcriptional Activation of the CXCL12 Promoter

Journal of Molecular Biology

Volumn 396, Issue 3, 2010, Pages 463-472

  Calonge, E ^a   Alonso Lobo, J M ^a   Escandon C ^a   Gonzalez N ^a   Bermejo, M ^a   Santiago, B ^b   Mestre, L ^c   Pablos, J L ^b   Caruz, A ^d   Alcami J ^a  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b HOSPITAL UNIVERSITARIO 12 DE OCTUBRE   (Spain)

^c INSTITUTO CAJAL   (Spain)

^d UNIVERSITY OF JAÉN   (Spain)

Author keywords

C EBP transcription factor; CXCL12 chemokine; Promoter regulation

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CCAAT ENHANCER BINDING PROTEIN BETA; INTERLEUKIN 1; INTERLEUKIN 6; STROMAL CELL DERIVED FACTOR 1; CXCL12 PROTEIN, HUMAN; CYTOKINE; DNA;

ARTICLE; BINDING AFFINITY; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENE LOCATION; HUMAN; HUMAN CELL; INFLAMMATION; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROMOTER REGION; STIMULUS; TRANSCRIPTION INITIATION; UPREGULATION; BIOSYNTHESIS; CELL LINE; CELL PROLIFERATION; DNA RESPONSIVE ELEMENT; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; PROTEIN BINDING;

BASE SEQUENCE; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL LINE; CELL PROLIFERATION; CHEMOKINE CXCL12; CHROMATIN IMMUNOPRECIPITATION; CYTOKINES; DNA; GENE EXPRESSION REGULATION; HUMANS; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RESPONSE ELEMENTS; TRANSCRIPTIONAL ACTIVATION;

EID: 77949333587     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2009.11.064     Document Type: Article

References (44)

1. Baggiolini M., Dewald B., Moser B. Human chemokines: an update. Annu. Rev. Immunol. 1997, 15:675-705.
2. Arai A., Jin A., Yan W., Mizuchi D., Yamamoto K., Nanki T., Miura O. SDF-1 synergistically enhances IL-3-induced activation of the Raf-1/MEK/Erk signaling pathway through activation of Rac and its effector Pak kinases to promote hematopoiesis and chemotaxis. Cell. Signal. 2005, 17:497-506.
3. Bleul C.C., Fuhlbrigge R.C., Casasnovas J.M., Aiuti A., Springer T.A. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J. Exp. Med. 1996, 184:1101-1109.
4. Jo D.Y., Rafii S., Hamada T., Moore M.A. Chemotaxis of primitive hematopoietic cells in response to stromal cell-derived factor-1. J. Clin. Invest. 2000, 105:101-111.
5. Lapidot T., Dar A., Kollet O. How do stem cells find their way home?. Blood 2005, 106:1901-1910.
6. Rossi D., Zlotnik A. The biology of chemokines and their receptors. Annu. Rev. Immunol. 2000, 18:217-242.
7. Salvucci O., Yao L., Villalba S., Sajewicz A., Pittaluga S., Tosato G. Regulation of endothelial cell branching morphogenesis by endogenous chemokine stromal-derived factor-1. Blood 2002, 99:2703-2711.
8. Kim K.J., Kim H.H., Kim J.H., Choi Y.H., Kim Y.H., Cheong J.H. Chemokine stromal cell-derived factor-1 induction by C/EBPbeta activation is associated with all-trans-retinoic acid-induced leukemic cell differentiation. J. Leukoc. Biol. 2007, 82:1332-1339.
9. Chen M., Xie H.Q., Deng L., Li X.Q., Wang Y., Zhi W., Yang Z.M. Stromal cell-derived factor-1 promotes bone marrow-derived cells differentiation to cardiomyocyte phenotypes in vitro. Cell Prolif. 2008, 41:336-347.
10. Shirozu M., Nakano T., Inazawa J., Tashiro K., Tada H., Shinohara T., Honjo T. Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics 1995, 28:495-500.
11. Yu L., Cecil J., Peng S.B., Schrementi J., Kovacevic S., Paul D., et al. Identification and expression of novel isoforms of human stromal cell-derived factor 1. Gene 2006, 374:174-179.
12. Burger J.A., Kipps T.J. CXCR4: a key receptor in the crosstalk between tumor cells and their microenvironment. Blood 2006, 107:1761-1767.
13. Orimo A., Gupta P.B., Sgroi D.C., Arenzana-Seisdedos F., Delaunay T., Naeem R., et al. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005, 121:335-348.
14. Pablos J.L., Santiago B., Galindo M., Torres C., Brehmer M.T., Blanco F.J., Garcia-Lazaro F.J. Synoviocyte-derived CXCL12 is displayed on endothelium and induces angiogenesis in rheumatoid arthritis. J. Immunol. 2003, 170:2147-2152.
15. Ponomaryov T., Peled A., Petit I., Taichman R.S., Habler L., Sandbank J., et al. Induction of the chemokine stromal-derived factor-1 following DNA damage improves human stem cell function. J. Clin. Invest. 2000, 106:1331-1339.
16. Ceradini D.J., Gurtner G.C. Homing to hypoxia: HIF-1 as a mediator of progenitor cell recruitment to injured tissue. Trends Cardiovasc. Med. 2005, 15:57-63.
17. Garcia-Moruja C., Alonso-Lobo J.M., Rueda P., Torres C., Gonzalez N., Bermejo M., et al. Functional characterization of SDF-1 proximal promoter. J. Mol. Biol. 2005, 348:43-62.
18. Ehtesham M., Winston J.A., Kabos P., Thompson R.C. CXCR4 expression mediates glioma cell invasiveness. Oncogene 2006, 25:2801-2806.
19. Hong X., Jiang F., Kalkanis S.N., Zhang Z.G., Zhang X.P., deCarvalho A.C., et al. SDF-1 and CXCR4 are up-regulated by VEGF and contribute to glioma cell invasion. Cancer Lett. 2006, 236:39-45.
20. Zhou Y., Larsen P.H., Hao C., Yong V.W. CXCR4 is a major chemokine receptor on glioma cells and mediates their survival. J. Biol. Chem. 2002, 277:49481-49487.
21. Mukhopadhyay P., Ali M.A., Nandi A., Carreon P., Choy H., Saha D. The cyclin-dependent kinase 2 inhibitor down-regulates interleukin-1beta-mediated induction of cyclooxygenase-2 expression in human lung carcinoma cells. Cancer Res. 2006, 66:1758-1766.
22. Hoelzinger D.B., Demuth T., Berens M.E. Autocrine factors that sustain glioma invasion and paracrine biology in the brain microenvironment. J. Natl. Cancer Inst. 2007, 99:1583-1593.
23. Somasundaram R., Herlyn D. Chemokines and the microenvironment in neuroectodermal tumor-host interaction. Semin. Cancer Biol. 2009, 19:92-96.
24. Findlay J.K., Drummond A.E. Regulation of the FSH receptor in the ovary. Trends Endocrinol. Metab. 1999, 10:183-188.
25. Szabo G., Katarova Z., Kortvely E., Greenspan R.J., Urban Z. Structure and the promoter region of the mouse gene encoding the 67-kD form of glutamic acid decarboxylase. DNA Cell Biol. 1996, 15:1081-1091.
26. Tanabe T., Tohnai N. Cyclooxygenase isozymes and their gene structures and expression. Prostaglandins Other Lipid Mediat. 2002, 68-69:95-114.
27. Atchley W.R., Fitch W.M. A natural classification of the basic helix-loop-helix class of transcription factors. Proc. Natl Acad. Sci. USA 1997, 94:5172-5176.
28. Tabatabai G., Frank B., Mohle R., Weller M., Wick W. Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-beta-dependent HIF-1alpha-mediated induction of CXCL12. Brain 2006, 129:2426-2435.
29. Leitlein J., Aulwurm S., Waltereit R., Naumann U., Wagenknecht B., Garten W., et al. Processing of immunosuppressive pro-TGF-beta 1,2 by human glioblastoma cells involves cytoplasmic and secreted furin-like proteases. J. Immunol. 2001, 166:7238-7243.
30. Pan J.J., Chang W.J., Barone T.A., Plunkett R.J., Ostrow P.T., Greenberg S.J. Increased expression of TGF-beta1 reduces tumor growth of human U-87 glioblastoma cells in vivo. Cancer Immunol. Immunother. 2006, 55:918-927.
31. Aldinucci C., Maiorca S.M., De R.P., Palmi M., Sticozzi C., Ciccoli L., et al. The effects of hypoxia/reoxygenation on the physiological behaviour of U373-Mg astrocytes. Neurochem. Res. 2009, 10.1007/s11064-009-0028-3.
32. Gillespie D.L., Whang K., Ragel B.T., Flynn J.R., Kelly D.A., Jensen R.L. Silencing of hypoxia inducible factor-1alpha by RNA interference attenuates human glioma cell growth in vivo. Clin. Cancer Res. 2007, 13:2441-2448.
33. Saidi A., Hagedorn M., Allain N., Verpelli C., Sala C., Bello L., et al. Combined targeting of interleukin-6 and vascular endothelial growth factor potently inhibits glioma growth and invasiveness. Int. J. Cancer 2009, 125:1054-1064.
34. Kudo M., Jono H., Shinriki S., Yano S., Nakamura H., Makino K., et al. Antitumor effect of humanized anti-interleukin-6 receptor antibody (tocilizumab) on glioma cell proliferation. Laboratory investigation. J. Neurosurg. 2009, 111:219-225.
35. Ramji D.P., Foka P. CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem. J. 2002, 365:561-575.
36. Pham T.H., Langmann S., Schwarzfischer L., El C.C., Lichtinger M., Klug M., et al. CCAAT enhancer-binding protein beta regulates constitutive gene expression during late stages of monocyte to macrophage differentiation. J. Biol. Chem. 2007, 282:21924-21933.
37. Laiosa C.V., Stadtfeld M., Xie H., de Andres-Aguayo L., Graf T. Reprogramming of committed T cell progenitors to macrophages and dendritic cells by C/EBP alpha and PU.1 transcription factors. Immunity 2006, 25:731-744.
38. Xie H., Ye M., Feng R., Graf T. Stepwise reprogramming of B cells into macrophages. Cell 2004, 117:663-676.
39. Cram E.J., Ramos R.A., Wang E.C., Cha H.H., Nishio Y., Firestone G.L. Role of the CCAAT/enhancer binding protein-alpha transcription factor in the glucocorticoid stimulation of p21waf1/cip1 gene promoter activity in growth-arrested rat hepatoma cells. J. Biol. Chem. 1998, 273:2008-2014.
40. Hocke G.M., Barry D., Fey G.H. Synergistic action of interleukin-6 and glucocorticoids is mediated by the interleukin-6 response element of the rat alpha 2 macroglobulin gene. Mol. Cell. Biol. 1992, 12:2282-2294.
41. Nishio Y., Isshiki H., Kishimoto T., Akira S. A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat alpha 1-acid glycoprotein gene via direct protein-protein interaction. Mol. Cell. Biol. 1993, 13:1854-1862.
42. Yang J.Q., Rudiger J.J., Hughes J.M., Goulet S., Gencay-Cornelson M.M., Borger P., et al. Cell density and serum exposure modify the function of the glucocorticoid receptor C/EBP complex. Am. J. Respir. Cell Mol. Biol. 2008, 38:414-422.
43. Hernandez-Lopez C., Valencia J., Hidalgo L., Martinez V.G., Zapata A.G., Sacedon R., et al. CXCL12/CXCR4 signaling promotes human thymic dendritic cell survival regulating the Bcl-2/Bax ratio. Immunol. Lett. 2008, 120:72-78.
44. Molina-Holgado E., Vela J.M., Arevalo-Martin A., Almazan G., Molina-Holgado F., Borrell J., Guaza C. Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling. J. Neurosci. 2002, 22:9742-9753.