Long-term tegaserod treatment for dysmotility-like functional dyspepsia: Results of two identical 1-year cohort studies

Digestive Diseases and Sciences

Volumn 55, Issue 3, 2010, Pages 684-697

  Chey, William D ^a   Howden, Colin W ^b   Tack, Jan ^c   Ligozio, Gregory ^d   Earnest, David L ^d  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^d NOVARTIS PHARMA AG   (Switzerland)

Author keywords

Dysmotility; Dyspepsia; Long term; Quality of life; Safety; Tegaserod

Indexed keywords

PLACEBO; TEGASEROD; GASTROINTESTINAL AGENT; INDOLE DERIVATIVE;

ABDOMINAL DISTENSION; ABDOMINAL PAIN; ADULT; ARTICLE; BRADYCARDIA; BREAST CANCER; CLINICAL TRIAL; COHORT ANALYSIS; CONSTIPATION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DIABETES MELLITUS; DIARRHEA; DIZZINESS; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG INDUCED HEADACHE; DRUG RESPONSE; DRUG SAFETY; DRUG WITHDRAWAL; DYSLIPIDEMIA; DYSPEPSIA; FEMALE; FUNCTIONAL DYSPEPSIA; HEART ATRIUM FIBRILLATION; HEART INFARCTION; HEART MURMUR; HEART PALPITATION; HUMAN; LONG TERM CARE; MAJOR CLINICAL STUDY; MASTALGIA; MULTICENTER STUDY; MUSCULOSKELETAL DISEASE; NAUSEA; OUTCOME ASSESSMENT; PERIPHERAL VASCULAR DISEASE; PRIORITY JOURNAL; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; SUPRAVENTRICULAR PREMATURE BEAT; SYNCOPE; TACHYCARDIA; THORAX PAIN; TIETZE SYNDROME; VOMITING; QUESTIONNAIRE;

ADULT; DOUBLE-BLIND METHOD; DYSPEPSIA; FEMALE; GASTROINTESTINAL AGENTS; HUMANS; INDOLES; QUALITY OF LIFE; QUESTIONNAIRES;

EID: 77949333044     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-009-1049-0     Document Type: Article

References (26)

1. S Mahadeva KL Goh 2006 Epidemiology of functional dyspepsia: a global perspective World J Gastroenterol 12 17 2661 2666 16718749 (Pubitemid 43796472)
2. J Tack NJ Talley M Camilleri, et al. 2006 Functional gastroduodenal disorders Gastroenterology 130 5 1466 1479 10.1053/j.gastro.2005.11.059 16678560
3. Drossman DA, Corazziari E, Talley NJ, Thompson WG, Whitehead W. Rome II: The Functional Gastrointestinal Disorders. McLean, VA: Degnon Associates; 2000.
4. V Stanghellini C Tosetti G Barbara, et al. 2002 Dyspeptic symptoms and gastric emptying in the irritable bowel syndrome Am J Gastroenterol 97 11 2738 2743 10.1111/j.1572-0241.2002.07062.x 12425541 (Pubitemid 35265422)
5. J Keohane EM Quigley 2007 Functional dyspepsia and nonerosive reflux disease: clinical interactions and their implications MedGenMed 9 3 31 18092037 (Pubitemid 47249281)
6. NJ Talley 2008 Functional gastrointestinal disorders as a public health problem Neurogastroenterol Motil 20 Suppl. 1 121 129 10.1111/j.1365-2982.2008. 01097.x 18402649 (Pubitemid 351514531)
7. CL Lu HC Lang FY Chang, et al. 2005 Prevalence and health/social impacts of functional dyspepsia in Taiwan: a study based on the Rome criteria questionnaire survey assisted by endoscopic exclusion among a physical check-up population Scand J Gastroenterol 40 4 402 411 10.1080/00365520510012190 16028434 (Pubitemid 40546907)
8. 4 agonist, stimulates canine colonic motility and transit in vivo Gastroenterology 110 A724
9. 4 receptors Neurogastroenterol Motil 10 459 10.1046/j.1365-2982.1998.00086.x (Pubitemid 28181878)
10. 4 receptor agonist induces cAMP-mediated Cl-efflux from rat colonocytes Gastroenterology 116 G287
11. MD Gershon 2003 Serotonin and its implication for the management of irritable bowel syndrome Rev Gastroenterol Disord 3 Suppl. 2 S25 S34 12776000
12. A Schikowski M Thewiben C Mathis, et al. 2002 Serotonin type-4 receptors modulate the sensitivity of intramural mechanoreceptive afferents of the cat rectum Neurogastroenterol Motil 14 221 227 10.1046/j.1365-2982.2002.00328.x 1:STN:280:DC%2BD38zitVCgug%3D%3D 12061906 (Pubitemid 34639449)
13. N Vakil L Laine NJ Talley, et al. 2008 Tegaserod treatment for dysmotility-like functional dyspepsia: Results of two randomized, controlled trials Am J Gastroenterol 103 8 1906 1919 18616658
14. NJ Talley M Verlinden M Jones 2001 Quality of life in functional dyspepsia: responsiveness of the Nepean Dyspepsia Index and development of a new 10-item short form Aliment Pharmacol Ther 15 2 207 216 10.1046/j.1365-2036. 2001.00900.x 1:STN:280:DC%2BD3M7isF2nsw%3D%3D 11148439 (Pubitemid 32142498)
15. M Jones N Talley 2008 Estimation of the minimum clinically important difference (Mcid) for the Nepean Dyspepsia Index (Ndi), a validated quality of life (QOL) scale for functional dyspepsia Gastroenterology 134 Suppl. 1 A627
16. P Layer J Keller S Mueller-Lissner, et al. 2005 Tegaserod: long-term treatment for irritable bowel syndrome patients with constipation in primary care Digestion 71 4 238 244 10.1159/000087049 16024929 (Pubitemid 41166562)
17. G Tougas WJ Snape MH Otten, et al. 2002 Long-term safety of tegaserod in patients with constipation-predominant irritable bowel syndrome Aliment Pharmacol Ther 16 10 1701 1708 10.1046/j.1365-2036.2002.01347.x 1:CAS:528:DC%2BD38XotlOhsLc%3D 12269961
18. S Muller-Lissner MA Kamm A Musoglu, et al. 2006 Safety, tolerability, and efficacy of tegaserod over 13 months in patients with chronic constipation Am J Gastroenterol 101 11 2558 2569 17090282 (Pubitemid 44665253)
19. M Camilleri D Dubois B Coulie, et al. 2005 Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US Upper Gastrointestinal Study Clin Gastroenterol Hepatol 3 6 543 552 10.1016/S1542-3565(05)00153-9 15952096 (Pubitemid 40824747)
20. Moayyedi P, Soo S, Deeks J, et al. Eradication of Helicobacter pylori for non-ulcer dyspepsia. Cochrane Database Syst Rev. 2006;(2):CD002096. doi: 10.1002/14651858.CD002096.pub4.
21. HJ Pfannkuche T Buhl R Gamse, et al. 1995 The properties of a new prokinetically active drug SDZ HTF 919 Neurogastroenterol Motil 7 280
22. T Hiyama M Yoshihara K Matsuo, et al. 2007 Treatment of functional dyspepsia with serotonin agonists: a meta-analysis of randomized controlled trials J Gastroenterol Hepatol 22 10 1566 1570 10.1111/j.1440-1746.2006.04723.x 17845684 (Pubitemid 47383326)
23. Moayyedi P, Soo S, Deeks J, et al. Pharmacological interventions for non-ulcer dyspepsia. Cochrane Database Syst Rev. 2006;(4):CD001960. doi: 10.1002/14651858.CD001960.pub3.
24. 4 receptor agonists: similar but not the same Neurogastroenterol Motil 20 2 99 112 18199093
25. A Madisch S Miehlke J Labenz 2005 Management of functional dyspepsia: unsolved problems and new perspectives World J Gastroenterol 11 42 6577 6581 16425347 (Pubitemid 43072693)
26. RJ Saad WD Chey 2006 Review article: current and emerging therapies for functional dyspepsia Aliment Pharmacol Ther 24 3 475 492 10.1111/j.1365-2036. 2006.03005.x 1:STN:280:DC%2BD28vmtlOrsg%3D%3D 16886913 (Pubitemid 44051323)