Native-unlike long-lived intermediates along the folding pathway of the amyloidogenic protein β2-microglobulin revealed by real-time two-dimensional NMR

Journal of Biological Chemistry

Volumn 285, Issue 8, 2010, Pages 5827-5835

  Corazza, Alessandra ^a   Rennella, Enrico ^a   Schanda, Paul ^b,f   Mimmi, Maria Chiara ^a   Cutuil, Thomas ^b   Raimondi, Sara ^c,d   Giorgetti, Sofia ^c,d   Fogolari, Federico ^a   Viglino, Paolo ^a   Frydman, Lucio ^e   Gal, Maayan ^e   Bellotti, Vittorio ^c,d   Brutscher, Bernhard ^b   Esposito, Gennaro ^a  

^a UNIVERSITY OF UDINE   (Italy)

^b INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^c UNIVERSITY OF PAVIA   (Italy)

^d FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

^e WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^f ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMBIENT TEMPERATURES; AMYLOID FIBRIL; AMYLOID FIBRIL FORMATION; ATOMIC RESOLUTION; CLASS I; DIALYSIS-RELATED AMYLOIDOSIS; ENERGY LANDSCAPE; FIBRIL FORMATION; FLIP ANGLE; FOLDING PATHWAY; INTERMEDIATE SPECIE; KINETIC SCHEME; LIGHT CHAIN; LONG TERM; MAJOR HISTOCOMPATIBILITY COMPLEX; NMR TECHNIQUES; OPTICAL SPECTROSCOPIC; REFOLDING KINETICS; WILD TYPES;

DIALYSIS; GLYCOPROTEINS; NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPIC ANALYSIS; TWO DIMENSIONAL;

PROTEINS;

BETA 2 MICROGLOBULIN; AMYLOID;

AMYLOIDOSIS; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENVIRONMENTAL TEMPERATURE; ISOMERIZATION; MOLECULAR DYNAMICS; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN FOLDING; AMINO ACID SUBSTITUTION; CHEMISTRY; GENETICS; HUMAN; KINETICS; MISSENSE MUTATION;

AMINO ACID SUBSTITUTION; AMYLOID; BETA 2-MICROGLOBULIN; HUMANS; KINETICS; MUTATION, MISSENSE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN FOLDING;

EID: 77949320904     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.061168     Document Type: Article

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