KSHV-induced notch components render endothelial and mural cell characteristics and cell survival

Blood

Volumn 115, Issue 4, 2010, Pages 887-895

  Liu, Ren ^a   Li, Xiuqing ^a   Tulpule, Anil ^a   Zhou, Yue ^a   Scehnet, Jeffrey S ^a   Zhang, Shaobing ^a   Lee, Jong Soo ^a   Chaudhary, Preet M ^b   Jung, Jae ^a   Gill, Parkash S ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CALPONIN; CD133 ANTIGEN; DESMIN; FLICE INHIBITORY PROTEIN; GAMMA SECRETASE INHIBITOR; INTERLEUKIN 6; JAGGED1; LATENCY ASSOCIATED NUCLEAR ANTIGEN; NOTCH RECEPTOR; NOTCH2 RECEPTOR; NOTCH3 RECEPTOR; NOTCH4 RECEPTOR; VIRUS PROTEIN; CALCIUM BINDING PROTEIN; DLL4 PROTEIN, HUMAN; MEMBRANE PROTEIN; NOTCH1 PROTEIN, HUMAN; NOTCH1 RECEPTOR; NOTCH2 PROTEIN, HUMAN; NOTCH3 PROTEIN, HUMAN; NOTCH4 PROTEIN, HUMAN; ONCOPROTEIN; SERRATE PROTEINS; SIGNAL PEPTIDE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL DEDIFFERENTIATION; CELL GROWTH; CELL LINE; CELL SURVIVAL; CELL TRANSDIFFERENTIATION; CELL TRANSFORMATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GROWTH INHIBITION; HERPES VIRUS INFECTION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; IN VIVO STUDY; LYMPH VESSEL ENDOTHELIUM; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR CELL; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CYTOLOGY; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; GENETICS; METABOLISM; NUDE MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; UMBILICAL ARTERY; UMBILICAL VEIN; VIROLOGY; VIRUS CELL TRANSFORMATION; VIRUS LATENCY; XENOGRAFT;

ANIMALS; CALCIUM-BINDING PROTEINS; CELL SURVIVAL; CELL TRANSFORMATION, VIRAL; CELLS, CULTURED; ENDOTHELIAL CELLS; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRIDAE INFECTIONS; HERPESVIRUS 8, HUMAN; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; MICE, NUDE; PROTO-ONCOGENE PROTEINS; RECEPTOR, NOTCH1; RECEPTOR, NOTCH2; RECEPTORS, NOTCH; RNA, SMALL INTERFERING; TRANSFECTION; TRANSPLANTATION, HETEROLOGOUS; UMBILICAL ARTERIES; UMBILICAL VEINS; VIRUS LATENCY;

EID: 77949317451     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-08-236745     Document Type: Article

References (49)

1. Chang Y, Cesarman E, Pessin MS, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi's sarcoma. Science. 1994;266(5192):1865-1869.
2. Staskus KA, Zhong W, Gebhard K, et al. Kaposi's sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol. 1997;71(1):715-719. (Pubitemid 26412345)
3. Sturzl M, Hohenadl C, Zietz C, et al. Expression of K13/v-FLIP gene of human herpesvirus 8 and apoptosis in Kaposi's sarcoma spindle cells. J Natl Cancer Inst. 1999;91(20):1725-1733. (Pubitemid 29518767)
4. Lan K, Verma SC, Murakami M, Bajaj B, Kaul R, Robertson ES. Kaposi's sarcoma herpesvirusen-coded latency-associated nuclear antigen stabilizes intracellular activated notch by targeting the Sel10 protein. Proc Natl Acad Sci U S A. 2007;104(41):16287-16292. (Pubitemid 350099398)
5. Sun Q, Zachariah S, Chaudhary PM. The human herpes virus 8-encoded viral FLICE-inhibitory protein induces cellular transformation via NF-kappaB activation. J Biol Chem. 2003;278(52): 52437-52445. (Pubitemid 38035836)
6. Bais C, Santomasso B, Coso O, et al. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature. 1998;391(6662):86-89. (Pubitemid 28079220)
7. Nicholas J, Ruvolo VR, Burns WH, et al. Kaposi's sarcoma-associated human herpesvirus-8 encodes homologues of macrophage inflammatory protein-1 and interleukin-6. Nat Med. 1997;3(3): 287-292. (Pubitemid 27112925)
8. Sun R, Lin SF, Gradoville L, Yuan Y, Zhu F, Miller G. A viral gene that activates lytic cycle expression of Kaposi's sarcoma-associated herpesvirus. Proc Natl Acad Sci U S A. 1998;95(18):10866-10871. (Pubitemid 28413160)
9. Liang Y, Chang J, Lynch SJ, Lukac DM, Ganem D. The lytic switch protein of KSHV activates gene expression via functional interaction with RBP-Jkappa (CSL), the target of the notch signaling pathway. Genes Dev. 2002;16(15):1977-1989.
10. Curry CL, Reed LL, Golde TE, Miele L, Nickoloff BJ, Foreman KE. Gamma secretase inhibitor blocks notch activation and induces apoptosis in Kaposi's sarcoma tumor cells. Oncogene. 2005; 24(42):6333-6344. (Pubitemid 41486467)
11. Struhl G, Adachi A. Nuclear access and action of notch in vivo. Cell. 1998;93(4):649-660. (Pubitemid 28240725)
12. Bolos V, Grego-Bessa J, de la Pompa JL. Notch signaling in development and cancer. Endocr Rev. 2007;28(3):339-363.
13. Swift MR, Weinstein BM. Arterial-venous specification during development. Circ Res. 2009;104(5):576-588.
14. Domenga V, Fardoux P, Lacombe P, et al. Notch3 is required for arterial identity and maturation of vascular smooth muscle cells. Genes Dev. 2004; 18(22):2730-2735. (Pubitemid 39507766)
15. Huppert SS, Le A, Schroeter EH, et al. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature. 2000; 405(6789):966-970.
16. Xue Y, Gao X, Lindsell CE, et al. Embryonic lethality and vascular defects in mice lacking the notch ligand Jagged1. Hum Mol Genet. 1999; 8(5):723-730. (Pubitemid 29189039)
17. Duarte A, Hirashima M, Benedito R, et al. Dosage-sensitive requirement for mouse Dll4 in artery development. Genes Dev. 2004;18(20):2474-2478. (Pubitemid 39362889)
18. Wang Z, Li Y, Banerjee S, Sarkar FH. Emerging role of notch in stem cells and cancer. Cancer Lett. 2009;279(1):8-12.
19. Maillard I, Pear WS. Notch and cancer: best to avoid the ups and downs. Cancer Cell. 2003;3(3): 203-205. (Pubitemid 37443875)
20. Hirakawa S, Hong YK, Harvey N, et al. Identification of vascular lineage-specific genes by transcriptional profiling of isolated blood vascular and lymphatic endothelial cells. Am J Pathol. 2003; 162(2):575-586. (Pubitemid 36267864)
21. Vieira J, O'Hearn PM. Use of the red fluorescent protein as a marker of Kaposi's sarcoma-associated herpesvirus lytic gene expression. Virology. 2004;325(2):225-240. (Pubitemid 38902789)
22. Albini A, Paglieri I, Orengo G, et al. The beta-core fragment of human chorionic gonadotrophin inhibits growth of Kaposi's sarcoma-derived cells and a new immortalized Kaposi's sarcoma cell line. AIDS. 1997;11(6):713-721. (Pubitemid 27186940)
23. Matta H, Surabhi RM, Zhao J, et al. Induction of spindle cell morphology in human vascular endothelial cells by human herpesvirus 8-encoded viral FLICE inhibitory protein K13. Oncogene. 2007;26(11):1656-1660. (Pubitemid 46398733)
24. Liu H, Kennard S, Lilly B. NOTCH3 expression is induced in mural cells through an autoregulatory loop that requires endothelial-expressed JAGGED1. Circ Res. 2009;104(4):466-475.
25. Scehnet JS, Ley EJ, Krasnoperov V, et al. The role of ephs, ephrins, and growth factors in Kaposi sarcoma and implications of EphrinB2 blockade. Blood. 2009;113(1):254-263.
26. Kumar SR, Singh J, Xia G, et al. Receptor tyrosine kinase EphB4 is a survival factor in breast cancer. Am J Pathol. 2006;169(1):279-293.
27. Bettenhausen B, Hrabe de Angelis M, Simon D, Guenet JL, Gossler A. Transient and restricted expression during mouse embryogenesis of Dll1, a murine gene closely related to drosophila delta. Development. 1995;121(8):2407-2418.
28. An FQ, Folarin HM, Compitello N, et al. Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivo. J Virol. 2006;80(10):4833-4846.
29. Weich HA, Salahuddin SZ, Gill P, Nakamura S, Gallo RC, Folkmann J. AIDS-associated Kaposi's sarcoma-derived cells in long-term culture express and synthesize smooth muscle alpha-actin. Am J Pathol. 1991;139(6):1251-1258.
30. Peichev M, Naiyer AJ, Pereira D, et al. Expression of VEGFR-2 and AC133 by circulating human CD34(+) cells identifies a population of functional endothelial precursors. Blood. 2000; 95(3):952-958. (Pubitemid 30062717)
31. Bagley RG, Rouleau C, St Martin T, et al. Human endothelial precursor cells express tumor endothelial marker 1/endosialin/CD248. Mol Cancer Ther. 2008;7(8):2536-2546.
32. Grossmann C, Podgrabinska S, Skobe M, Ganem D. Activation of NF-kappaB by the latent vFLIP gene of Kaposi's sarcoma-associated herpesvirus is required for the spindle shape of virus-infected endothelial cells and contributes to their proinflammatory phenotype. J Virol. 2006;80(14): 7179-7185.
33. Cannon ML, Cesarman E. The KSHV G protein-coupled receptor signals via multiple pathways to induce transcription factor activation in primary effusion lymphoma cells. Oncogene. 2004;23(2): 514-523. (Pubitemid 38175006)
34. Cai J, Gill PS, Masood R, et al. Oncostatin-M is an autocrine growth factor in Kaposi's sarcoma. Am J Pathol. 1994;145(1):74-79. (Pubitemid 24217485)
35. Nagpal S, Cai J, Zheng T, et al. Retinoid antagonism of NF-IL-6: insight into the mechanism of antiproliferative effects of retinoids in Kaposi's sarcoma. Mol Cell Biol. 1997;17(7):4159-4168. (Pubitemid 27281892)
36. Lane BR, Liu J, Bock PJ, et al. Interleukin-8 and growth-regulated oncogene alpha mediate angiogenesis in Kaposi's sarcoma. J Virol. 2002; 76(22):11570-11583. (Pubitemid 35231313)
37. Scehnet JS, Jiang W, Kumar SR, et al. Inhibition of Dll4-mediated signaling induces proliferation of immature vessels and results in poor tissue perfusion. Blood. 2007;109(11):4753-4760. (Pubitemid 46827768)
38. Hellstrom M, Phng LK, Hofmann JJ, et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis. Nature. 2007; 445(7129):776-780. (Pubitemid 46279716)
39. Trindade A, Kumar SR, Scehnet JS, et al. Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos. Blood. 2008;112(5):1720-1729.
40. Bais C, Van Geelen A, Eroles P, et al. Kaposi's sarcoma associated herpesvirus G protein-coupled receptor immortalizes human endothelial cells by activation of the VEGF receptor-2/ KDR. Cancer Cell. 2003;3(2):131-143. (Pubitemid 37443386)
41. Lobov IB, Renard RA, Papadopoulos N, et al. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting. Proc Natl Acad Sci U S A. 2007;104(9):3219-3224. (Pubitemid 46364140)
42. Yang TY, Chen SC, Leach MW, et al. Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi's sarcoma. J Exp Med. 2000;191(3):445-454.
43. Wan X, Wang H, Nicholas J. Human herpesvirus 8 interleukin-6 (vIL-6) signals through gp130 but has structural and receptor-binding properties distinct from those of human IL-6. J Virol. 1999; 73(10):8268-8278. (Pubitemid 29441688)
44. Yang J, Hagan MK, Offermann MK. Induction of IL-6 gene expression in Kaposi's sarcoma cells. J Immunol. 1994;152(2):943-955. (Pubitemid 24073000)
45. Adam N, Rabe B, Suthaus J, Grotzinger J, Rose-John S, Scheller J. Unraveling viral interleukin-6 binding to gp130 and activation of STAT-signaling pathways independently of the interleukin-6 receptor. J Virol. 2009;83(10):5117-5126.
46. Burdon T, Smith A, Savatier P. Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol. 2002;12(9):432-438. (Pubitemid 35239952)
47. Nair BC, DeVico AL, Nakamura S, et al. Identification of a major growth factor for AIDS-Kaposi's sarcoma cells as oncostatin M. Science. 1992; 255(5050):1430-1432.
48. Georgakopoulos A, Litterst C, Ghersi E, et al. Metalloproteinase/ Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signaling. EMBO J. 2006;25(6):1242-1252.
49. Li T, Wen H, Brayton C, et al. Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. J Biol Chem. 2007;282(44):32264-32273. (Pubitemid 350106457)