Efficient synthesis of symmetrical α,α-disubstituted β-amino acids and α,α-disubstituted aldehydes via dialkylation of nucleophilic β-alanine equivalent

Journal of Organic Chemistry

Volumn 75, Issue 5, 2010, Pages 1717-1722

  Lin, Daizong ^a   Deng, Guanghui ^a   Wang, Jiang ^a   Ding, Xiao ^a   Jiang, Hualiang ^a   Liu, Hong ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALKYL HALIDES; ATOM ECONOMY; DECOMPOSITION METHODS; DIALKYLATION; EFFICIENT SYNTHESIS; EXPERIMENTAL PROCEDURE; GENERAL METHOD; INERT ATMOSPHERES; LOW TEMPERATURES; NI COMPLEXES; SCHIFF-BASE;

ALDEHYDES; ALKYLATION; AMINO ACIDS; FUNCTIONAL GROUPS; HYDROCARBONS; SYNTHESIS (CHEMICAL);

ORGANIC ACIDS;

1 (BROMOMETHYL) 4 NITROBENZENE; 2 [N (ALPHA PICOLYL) AMINO] BENZOPHENONE; ALDEHYDE; BENZOPHENONE; BETA ALANINE; BETA AMINO ACID; HALIDE; NICKEL COMPLEX; NUCLEOPHILE; SCHIFF BASE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DECOMPOSITION; DIALKYLATION; LOW TEMPERATURE; SYNTHESIS;

ALDEHYDES; ALKYLATION; AMINO ACIDS; BETA-ALANINE; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; NICKEL; ORGANOMETALLIC COMPOUNDS; SCHIFF BASES; STEREOISOMERISM;

EID: 77949293416     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo902699t     Document Type: Article

References (2)

1. f) Wang, J.; Shi, J. M.; Zhang, X. D.; Lin, D. Z.; Jiang, H. L.; Liu, H. Synthesis 2009, 1744-1752.
2. a) Soloshonok, V. A.; Cai, C.; Hruby, V. J. Tetrahedron Lett. 2000, 41, 135-139.