Detection of responsible mutations for beta thalassemia in the Kermanshah Province of Iran using PCR-based techniques

Molecular Biology Reports

Volumn 37, Issue 1, 2010, Pages 149-154

  Rahimi, Zohreh ^a,b   Muniz, Adriana ^c   Parsian, Abbas ^d  

^a KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^d NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Beta thalassemia; Molecular analysis; Mutation; Western Iran

Indexed keywords

CD15 ANTIGEN; CD36 ANTIGEN; CD37 ANTIGEN; CD8 ANTIGEN; CD9 ANTIGEN;

ADOLESCENT; ALLELE; ANALYTIC METHOD; ARTICLE; BETA THALASSEMIA; BETA THALASSEMIA INTERMEDIA; CHROMOSOME MUTATION; DIRECT GENOMIC SEQUENCING; ETHNIC GROUP; FEMALE; GENE SEQUENCE; GENETIC SCREENING; HUMAN; IRAN; MAJOR CLINICAL STUDY; MALE; MUTATIONAL ANALYSIS; POLYMERASE CHAIN REACTION; POLYMERASE CHAIN REACTION AMPLIFICATION REFRACTORY MUTATION SYSTEM; POPULATION GENETICS; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; THALASSEMIA MAJOR;

ADOLESCENT; BETA-THALASSEMIA; FEMALE; GEOGRAPHY; HUMANS; IRAN; MALE; MUTATION; POLYMERASE CHAIN REACTION;

EID: 77949272252     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-009-9560-0     Document Type: Article

References (27)

1. VC Reichert SM de Castro SC Wagner DM de Albuquerque MH Hutz S Leistner-Segal 2008 Identification of β-thalassemia mutations in South Brazilians Ann Hematol 87 381 384 10.1007/s00277-007-0418-z 10.1007/s00277-007- 0418-z 1:CAS:528:DC%2BD1cXjslSrsbw%3D 18071703
2. H Abolghasemi A Amid S Zeinali MH Radfar P Eshghi MS Rahiminejad MA Ehsani H Najmabadi MT Akbari A Afrasiabi H Akhavan-Niaki H Hoorfar 2007 Thalassemia in Iran: epidemiology, prevention and management J Pediatr Hematol Oncol 29 233 238 10.1097/MPH.0b013e3180437e02 10.1097/MPH.0b013e3180437e02 17414565 (Pubitemid 46597687)
3. Weatheral DJ (2001) The thalassemia. In: Beutler E, Lichtman MA, Coller BS, Kipps TJ, Seligsohn U (eds) Williams hematology, 6th edn. McGraw-Hill, New York, pp 547-580
4. N Ghotbi T Tsukatani 2005 Evaluation of the national health policy of thalassemia screening in the Islamic Republic of Iran East Mediterr Health J 11 308 318 1:STN:280:DC%2BD287ps1Ckug%3D%3D 16602449
5. H Najmabadi R Karimi-Nejad S Sahebjam F Pourfarzad S Teimourian F Sahebjam N Amirizadeh MH Karimi-Nejad 2001 The β-thalassemia mutation spectrum in the Iranian population Hemoglobin 25 285 296 10.1081/HEM-100105221 10.1081/HEM-100105221 1:CAS:528:DC%2BD3MXmvF2mtLY%3D 11570721 (Pubitemid 32845932)
6. AA Kiani Y Mortazavi S Zeinali Y Shirkhani 2007 The molecular analysis of β-thalassemia mutations in Lorestan province, Iran Hemoglobin 31 343 349 10.1080/03630260701459382 10.1080/03630260701459382 1:CAS:528: DC%2BD2sXotFSjtrc%3D 17654071 (Pubitemid 47123781)
7. K Betke HR Marti I Schlict 1959 Estimation of small percentages of fetal haemoglobin Nature 184 1877 1878 10.1038/1841877a0 10.1038/1841877a0 1:CAS:528:DyaF3cXnsFSnsA%3D%3D 13800165
8. Fairbanks VF, Klee GG (1994) Biochemical aspects of hematology. In: Burtis CA, Ashwood ER (eds) Tietz text book of clinical chemistry. W.B. Saunders, Philadelphia, pp 2041-2042
9. Old JM, Higgs DR (1983) Gene analysis. In: Weatherall DJ (ed) Methods in hemotology, vol 6. The thalassemias, Livingstone, pp 74-101
10. Old JM (1996) Hemoglobinopathies. In: Elles R (ed) Methods in molecular medicine: molecular diagnosis of genetic disease. Humana press Inc, Totowa, pp 169-183
11. Gibbons JD (1971) Nonparametric statistical inference. McGrow-Hill, New York
12. G Nozari S Rahbar A Golshaiyzan S Rahmanzadeh 1995 Molecular analyses of β-thalassema in Iran Hemoglobin 19 425 431 10.3109/03630269509005836 10.3109/03630269509005836 1:CAS:528:DyaK2MXhtVSjurjK 8718703
13. MA Hosseinpour Feizi AA Hosseinpour Feizi N Pouladi M Haghi P Azarfam 2008 Molecular spectrum of β-thalassemia in Northwestern Iran Hemoglobin 32 255 261 10.1080/03630260802004145 10.1080/03630260802004145 1:CAS:528:DC%2BD1cXntFarsr8%3D 18473241 (Pubitemid 351882848)
14. P Derakhshandeh-Peykar H Akhavan-Niaki A Tamaddoni S Ghawidel-Parsa KH Naieni M Rahmani F Babrzadeh M Dilmaghani-Zadeh DD Farhud 2007 Distribution of β-thalassemia mutations in the northern province of Iran Hemoglobin 31 351 356 10.1080/03630260701462030 10.1080/03630260701462030 1:CAS:528: DC%2BD2sXotFSjtL8%3D 17654072 (Pubitemid 47123792)
15. M Karimi H Yarmohammadi S Farjadian S Zeinali Z Moghaddam MD Cappellini PC Giordano 2002 Beta-thalassemia intermedia from southern Iran: IVS-II-1 (G→A) is the prevalent thalassemia intermedia allele Hemoglobin 26 147 154 10.1081/HEM-120005452 10.1081/HEM-120005452 1:CAS:528:DC%2BD38XlsFClsL0%3D 12144057 (Pubitemid 34779263)
16. P Derakhshandeh-Peykar H Hourfar M Heidari M Kheirollahi M Miryounesi 2008 The spectrum of β-thalassemia mutations in Isfahan province of Iran Iran J Public Health 37 106 111 1:CAS:528:DC%2BD1MXnt1aiu74%3D
17. M Yavarian CL Harteveld D Batelaan LF Bernini PC Giordano 2001 Molecular spectrum of β-thalassemia in the Iranian province of Hormozgan Hemoglobin 25 35 43 10.1081/HEM-100103068 10.1081/HEM-100103068 1:CAS:528: DC%2BD3MXksFGiu78%3D 11300348 (Pubitemid 32249964)
18. P Eshghi A Zadeh-Vakili A Rashidi E Miri-Moghadam 2008 An unusually frequent beta-thalassemia mutation in an Iranian province Hemoglobin 32 387 392 10.1080/03630260701758932 10.1080/03630260701758932 1:CAS:528: DC%2BD1cXovFWksbY%3D 18654889
19. L Zahed M Qatanani M Nabulsi A Taher 2000 β-Thalassemia mutations and haplotype analysis in Lebanon Hemoglobin 24 269 276 10.3109/ 03630260008993133 10.3109/03630260008993133 1:CAS:528:DC%2BD3cXos1SmsLw%3D 11186256
20. MF Sadiq A Eigel J Horst 2001 Spectrum of β-thalassemia in Jordan: identification of two novel mutations Am J Hematol 68 16 22 10.1002/ajh.1143 10.1002/ajh.1143 1:CAS:528:DC%2BD3MXms1WitLk%3D 11559932 (Pubitemid 32738715)
21. K Kyriacou F Al-Quobaili E Pavlou G Christopoulos P Ioannou M Kleanthous 2000 Molecular characterization of β-thalassemia in Syria Hemoglobin 24 1 13 10.3109/03630260009002268 10.3109/03630260009002268 1:CAS:528: DC%2BD3cXhvVaktbw%3D 10722110
22. S Daar HM Hussein T Merghoub R Krishnamoorthy 1998 Spectrum of β-thalassemia mutations in Oman Ann N Y Acad Sci 850 404 406 10.1111/j.1749-6632.1998.tb10504.x 10.1111/j.1749-6632.1998.tb10504.x 1:STN:280:DyaK1czjtlWltg%3D%3D 9668567 (Pubitemid 28369787)
23. S El-Kalla AR Mathews 1997 A significant β-thalassemia heterogeneity in the United Arab Emirates Hemoglobin 21 237 247 10.3109/03630269708997384 10.3109/03630269708997384 1:CAS:528:DyaK2sXjtVGlsb8%3D 9140720
24. S haplotypes among Kuwaiti Arabs Acta Haematol 92 176 181 10.1159/000204216 10.1159/000204216 1:STN:280:DyaK2M3hs1Cluw%3D%3D 7701914
25. MA El-Hazmi AR Al-Swailem AS Warsy 1995 Molecular defects in beta-thalassemias in the population of Saudi Arabia Hum Hered 45 278 285 10.1159/000154314 10.1159/000154314 1:CAS:528:DyaK2MXotlWgsLo%3D 7590760
26. M Karimi N Jamalian H Yarmohammadi A Askarnejad A Afrasiabi A Hashemi 2007 Premarital screening for beta-thalassaemia in Southern Iran: options for improving the programme J Med Screen 14 62 66 10.1258/096914107781261882 10.1258/096914107781261882 17626703 (Pubitemid 47067758)
27. G Khorasani M Kosaryan K Vahidshahi S Shakeri MM Nasehi 2008 Results of the national program for prevention of beta-thalassemia major in the Iranian Province of Mazandaran Hemoglobin 32 263 271 10.1080/03630260802004269 10.1080/03630260802004269 1:CAS:528:DC%2BD1cXntFarsrw%3D 18473242 (Pubitemid 351882844)