Loss of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 and reduced O-glycosylation in colon carcinoma cells selected for hepatic metastasis

Glycoconjugate Journal

Volumn 27, Issue 2, 2010, Pages 267-276

  Kato, Kentaro ^a   Takeuchi, Hideyuki ^a   Kanoh, Akira ^a   Miyahara, Naoki ^a   Nemoto Sasaki, Yoko ^a   Morimoto Tomita, Megumi ^a   Matsubara, Azusa ^a   Ohashi, Yoshimi ^a   Waki, Michihiko ^a   Usami, Katsuaki ^a   Mandel, Ulla ^b   Clausen, Henrik ^c   Higashi, Nobuaki ^a   Irimura, Tatsuro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Mucin; O glycosylation; PpGalNAc T; UDP N acetyl D galactosamine:polypeptide N acetylgalactosaminyltransferases

Indexed keywords

POLYCLONAL ANTIBODY; URIDINE DIPHOSPHATE N ACETYLGALACTOSAMINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; COLON CARCINOMA; CONTROLLED STUDY; GLYCOSYLATION; LIVER METASTASIS; MICROSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ACETYLGALACTOSAMINE; AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES; CELL LINE, TUMOR; COLONIC NEOPLASMS; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOPEPTIDES; GLYCOSYLATION; HUMANS; LECTINS; LIVER NEOPLASMS; MICE; MICROSOMES; MOLECULAR SEQUENCE DATA; MUCINS; N-ACETYLGALACTOSAMINYLTRANSFERASES; RNA, MESSENGER; SUBSTRATE SPECIFICITY;

MURINAE;

EID: 77949270759     PISSN: 02820080     EISSN: 15734986     Source Type: Journal    
DOI: 10.1007/s10719-009-9275-4     Document Type: Article

References (43)

1. EP Bennett H Hassan H Clausen 1996 cDNA cloning and expression of a novel human UDP-N-acetyl-alpha-D-galactosamine. Polypeptide N- acetylgalactosaminyltransferase, GalNAc-t3 J Biol Chem. 271 17006 17012 10.1074/jbc.271.29.17006 1:CAS:528:DyaK28XksFant7s%3D 8663203 (Pubitemid 26244245)
2. EP Bennett H Hassan U Mandel E Mirgorodskaya P Roepstorff J Burchell J Taylor-Papadimitriou MA Hollingsworth G Merkx AG van Kessel H Eiberg R Steffensen H Clausen 1998 Cloning of a human UDP-N-acetyl-alpha-D-Galactosamine: polypeptide N-acetylgalactosaminyltransferase that complements other GalNAc-transferases in complete O-glycosylation of the MUC1 tandem repeat J Biol Chem. 273 30472 30481 10.1074/jbc.273.46.30472 1:CAS:528:DyaK1cXnsVyru7w%3D 9804815 (Pubitemid 28545522)
3. EP Bennett H Hassan MA Hollingsworth H Clausen 1999 A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates FEBS Lett. 460 226 230 10.1016/S0014-5793(99)01268-5 1:CAS:528: DyaK1MXmvFWnu7o%3D 10544240 (Pubitemid 29495945)
4. EP Bennett H Hassan U Mandel MA Hollingsworth N Akisawa Y Ikematsu G Merkx AG van Kessel S Olofsson H Clausen 1999 Cloning and characterization of a close homologue of human UDP-N-acetyl-alpha-D-galactosamine:Polypeptide N-acetylgalactosaminyltransferase-T3, designated GalNAc-T6. Evidence for genetic but not functional redundancy J Biol Chem. 274 25362 25370 10.1074/jbc.274.36. 25362 1:CAS:528:DyaK1MXmtVWitbk%3D 10464263 (Pubitemid 29418556)
5. L Cheng K Tachibana Y Zhang J Guo K Kahori Tachibana A Kameyama H Wang T Hiruma H Iwasaki A Togayachi T Kudo H Narimatsu 2002 Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T10 FEBS Lett. 531 115 121 10.1016/S0014-5793(02)03399-9 1:CAS:528:DC%2BD38Xotl2ntLk%3D 12417297 (Pubitemid 35341180)
6. L Cheng K Tachibana H Iwasaki A Kameyama Y Zhang T Kubota T Hiruma T Kudo JM Guo H Narimatsu 2004 Characterization of a novel human UDP-GalNAc transferase, pp-GalNAc-T15 FEBS Lett. 566 17 24 10.1016/j.febslet.2004.03.108 1:CAS:528:DC%2BD2cXktVOltrg%3D 15147861 (Pubitemid 38625925)
7. JM Guo Y Zhang L Cheng H Iwasaki H Wang T Kubota K Tachibana H Narimatsu 2002 Molecular cloning and characterization of a novel member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, pp-GalNAc-T12 FEBS Lett. 524 211 218 10.1016/S0014-5793(02)03007-7 1:CAS:528: DC%2BD38Xls1Wks74%3D 12135769 (Pubitemid 34804862)
8. T Schwientek EP Bennett C Flores J Thacker M Hollmann CA Reis J Behrens U Mandel B Keck MA Schafer K Haselmann R Zubarev P Roepstorff JM Burchell J Taylor-Papadimitriou MA Hollingsworth H Clausen 2002 Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in Drosophila J Biol Chem. 277 22623 22638 10.1074/jbc.M202684200 1:CAS:528:DC%2BD38XltVGktbw%3D 11925450 (Pubitemid 34967240)
9. AD Simmons MM Musy CS Lopes LY Hwang YP Yang M Lovett 1999 A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses Hum Mol Genet. 8 2155 2164 10.1093/hmg/8.12.2155 1:CAS:528:DyaK1MXnsVGns7c%3D 10545594 (Pubitemid 29525329)
10. S Toba M Tenno M Konishi T Mikami N Itoh A Kurosaka 2000 Brain-specific expression of a novel human UDP-GalNAc:polypeptide N- acetylgalactosaminyltransferase (GalNAc-T9) Biochim Biophys Acta. 1493 264 268 1:CAS:528:DC%2BD3cXmt1Sntr8%3D 10978536
11. H Wang K Tachibana Y Zhang H Iwasaki A Kameyama L Cheng J Guo T Hiruma A Togayachi T Kudo N Kikuchi H Narimatsu 2003 Cloning and characterization of a novel UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, pp-GalNAc-T14 Biochem Biophys Res Commun. 300 738 744 10.1016/S0006-291X(02)02908-X 1:CAS:528:DC%2BD38XpvVWls78%3D 12507512 (Pubitemid 36268899)
12. KE White B Lorenz WE Evans T Meitinger TM Strom MJ Econs 2000 Molecular cloning of a novel human UDP-GalNAc:polypeptide N- acetylgalactosaminyltransferase, GalNAc-T8, and analysis as a candidate autosomal dominant hypophosphatemic rickets (ADHR) gene Gene. 246 347 356 10.1016/S0378-1119(00)00050-0 1:CAS:528:DC%2BD3cXitlersL8%3D 10767557 (Pubitemid 30192133)
13. T White EP Bennett K Takio T Sorensen N Bonding H Clausen 1995 Purification and cDNA cloning of a human UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase J Biol Chem. 270 24156 24165 10.1074/jbc.270.41.24156 1:CAS:528:DyaK2MXovVSgtL0%3D 7592619
14. Y Zhang H Iwasaki H Wang T Kudo TB Kalka T Hennet T Kubota L Cheng N Inaba M Gotoh A Togayachi J Guo H Hisatomi K Nakajima S Nishihara M Nakamura JD Marth H Narimatsu 2003 Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen J Biol Chem. 278 573 584 10.1074/jbc.M203094200 1:CAS:528:DC%2BD38XpvVWnsrg%3D 12407114 (Pubitemid 36043611)
15. FK Hagen KG Ten Hagen TM Beres MM Balys BC VanWuyckhuyse LA Tabak 1997 cDNA cloning and expression of a novel UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase J Biol Chem. 272 13843 13848 10.1074/jbc.272.21.13843 1:CAS:528:DyaK2sXjsFWht7w%3D 9153242 (Pubitemid 27224824)
16. FK Hagen B Hazes R Raffo D deSa LA Tabak 1999 Structure-function analysis of the UDP-N-acetyl-D-galactosamine:polypeptide N- acetylgalactosaminyltransferase. Essential residues lie in a predicted active site cleft resembling a lactose repressor fold J Biol Chem. 274 6797 6803 10.1074/jbc.274.10.6797 1:CAS:528:DyaK1MXhs1eru74%3D 10037781 (Pubitemid 29111104)
17. J Zara FK Hagen KG Ten Hagen BC Van Wuyckhuyse LA Tabak 1996 Cloning and expression of mouse UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3 Biochem Biophys Res Commun. 228 38 44 10.1006/bbrc.1996.1613 8912633 (Pubitemid 26390627)
18. KG Ten Hagen TA Fritz LA Tabak 2003 All in the family: the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases Glycobiology. 13 1R 16R 10.1093/glycob/cwg007 12634319 (Pubitemid 36372510)
19. AP Elhammer FJ Kezdy A Kurosaka 1999 The acceptor specificity of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferases Glycoconj J. 16 171 180 10.1023/A:1026465232149 1:CAS:528:DyaK1MXntFSjsrk%3D 10612416 (Pubitemid 29472142)
20. FG Hanisch S Muller H Hassan H Clausen N Zachara AA Gooley H Paulsen K Alving J Peter-Katalinic 1999 Dynamic epigenetic regulation of initial O-glycosylation by UDP-N-Acetylgalactosamine:Peptide N- acetylgalactosaminyltransferases. site-specific glycosylation of MUC1 repeat peptide influences the substrate qualities at adjacent or distant Ser/Thr positions J Biol Chem. 274 9946 9954 10.1074/jbc.274.15.9946 1:CAS:528:DyaK1MXis1GjsLk%3D 10187769 (Pubitemid 29180856)
21. FG Hanisch CA Reis H Clausen H Paulsen 2001 Evidence for glycosylation-dependent activities of polypeptide N- acetylgalactosaminyltransferases rGalNAc-T2 and -T4 on mucin glycopeptides Glycobiology. 11 731 740 10.1093/glycob/11.9.731 1:CAS:528:DC%2BD3MXnsV2itrs%3D 11555617
22. Hassan, H., Bennett, E.P., Mandel, U., Hollingsworth, M.A., Clausen, H.: Control of mucin type O-glycosylation: O-glycan occupancy is directed by substrate specificities of polypeptide GalNAc-transferases. Wiley-VCH, Weinheim (2000)
23. S Hennebicq D Tetaert B Soudan A Boersma G Briand C Richet J Gagnon P Degand 1998 Influence of the amino acid sequence on the MUC5AC motif peptide O-glycosylation by human gastric UDP-GalNAc:polypeptide N- acetylgalactosaminyltransferase(s) Glycoconj J. 15 275 282 10.1023/A: 1006949129456 1:CAS:528:DyaK1cXitlGltLo%3D 9579804 (Pubitemid 28121379)
24. S Hennebicq D Tetaert B Soudan G Briand C Richet D Demeyer J Gagnon Y Petillot P Degand 1998 Polypeptide:N-acetylgalactosaminyltransferase activities towards the mucin MUC5AC peptide motif using microsomal preparations of normal and tumoral digestive mucosa Biochimie. 80 69 73 10.1016/S0300-9084(98)80058-8 1:CAS:528:DyaK1cXjt1Smsbw%3D 9587664 (Pubitemid 28211655)
25. K Kato H Takeuchi N Miyahara A Kanoh H Hassan H Clausen T Irimura 2001 Distinct orders of GalNAc incorporation into a peptide with consecutive threonines Biochem Biophys Res Commun. 287 110 115 10.1006/bbrc.2001.5562 1:CAS:528:DC%2BD3MXms1amsLk%3D 11549261 (Pubitemid 32912470)
26. B Soudan D Tetaert S Hennebicq G Briand F Zerimech C Richet D Demeyer J Gagnon Y Petillot P Degand 1998 Dipeptidyl aminotransferase activity and in vitro O-glycosylation of MUC5AC mucin motif peptides by human gastric microsomal preparations J Pept Res. 51 346 354 1:CAS:528:DyaK1cXis1GltrY%3D 9606014
27. H Takeuchi K Kato H Hassan H Clausen T Irimura 2002 O-GalNAc incorporation into a cluster acceptor site of three consecutive threonines.Distinct specificity of GalNAc-transferase isoforms Eur J Biochem. 269 6173 6183 10.1046/j.1432-1033.2002.03334.x 1:CAS:528:DC%2BD3sXht1Gmug%3D%3D 12473113 (Pubitemid 35461830)
28. HH Wandall H Hassan E Mirgorodskaya AK Kristensen P Roepstorff EP Bennett PA Nielsen MA Hollingsworth J Burchell J Taylor-Papadimitriou H Clausen 1997 Substrate specificities of three members of the human UDP-N-acetyl-alpha-D- galactosamine:Polypeptide N-acetylgalactosaminyltransferase family, GalNAc-T1, -T2, and -T3 J Biol Chem. 272 23503 23514 10.1074/jbc.272.38.23503 1:CAS:528:DyaK2sXmtlOnt78%3D 9295285 (Pubitemid 27410917)
29. K Kato H Takeuchi A Kanoh U Mandel H Hassan H Clausen T Irimura 2001 N-acetylgalactosamine incorporation into a peptide containing consecutive threonine residues by UDP-N-acetyl-D-galactosaminide:polypeptide N-acetylgalactosaminyltransferases Glycobiology. 11 821 829 10.1093/glycob/11. 10.821 1:CAS:528:DC%2BD3MXns1Gitr8%3D 11588158
30. TH Corbett DP Griswold Jr BJ Roberts JC Peckham FM Schabel Jr 1975 Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure Cancer Res. 35 2434 2439 1:CAS:528:DyaE2MXlsFyru7k%3D 1149045
31. M Morimoto-Tomita Y Ohashi A Matsubara M Tsuiji T Irimura 2005 Mouse colon carcinoma cells established for high incidence of experimental hepatic metastasis exhibit accelerated and anchorage-independent growth Clin Exp Metastasis. 22 513 521 10.1007/s10585-005-3585-0 16320114 (Pubitemid 41750703)
32. Y Nemoto-Sasaki M Mitsuki M Morimoto-Tomita A Maeda M Tsuiji T Irimura 2001 Correlation between the sialylation of cell surface Thomsen-Friedenreich antigen and the metastatic potential of colon carcinoma cells in a mouse model Glycoconj J. 18 895 906 10.1023/A:1022252509765 1:CAS:528:DC%2BD3sXotVyrsw%3D%3D 12820723 (Pubitemid 36315054)
33. ME Sutherlin I Nishimori T Caffrey EP Bennett H Hassan U Mandel D Mack T Iwamura H Clausen MA Hollingsworth 1997 Expression of three UDP-N-acetyl-alpha- D-galactosamine:polypeptide GalNAc N-acetylgalactosaminyltransferases in adenocarcinoma cell lines Cancer Res. 57 4744 4748 1:CAS:528:DyaK2sXnt12gurY%3D 9354435
34. A Kanoh H Takeuchi K Kato M Waki K Usami T Irimura 2008 Interleukin-4 induces specific pp-GalNAc-T expression and alterations in mucin O-glycosylation in colonic epithelial cells Biochim Biophys Acta. 1780 577 584 1:CAS:528:DC%2BD1cXjsVSitrY%3D 17916404
35. K Kato H Takeuchi T Ohki M Waki K Usami H Hassan H Clausen T Irimura 2008 A lectin recognizes differential arrangements of O-glycans on mucin repeats Biochem Biophys Res Commun. 371 698 701 10.1016/j.bbrc.2008.04.120 1:CAS:528:DC%2BD1cXmsFyrtr0%3D 18455506
36. M Nomoto H Izumi T Ise K Kato H Takano G Nagatani K Shibao R Ohta T Imamura M Kuwano K Matsuo Y Yamada H Itoh K Kohno 1999 Structural basis for the regulation of UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyl transferase-3 gene expression in adenocarcinoma cells Cancer Res. 59 6214 6222 1:CAS:528:DC%2BD3cXktFygtA%3D%3D 10626815
37. H Izumi R Ohta G Nagatani T Ise Y Nakayama M Nomoto K Kohno 2003 p300/CBP-associated factor (P/CAF) interacts with nuclear respiratory factor-1 to regulate the UDP-N-acetyl-alpha-d-galactosamine: polypeptide N-acetylgalactosaminyltransferase-3 gene Biochem J. 373 713 722 10.1042/BJ20021902 1:CAS:528:DC%2BD3sXlslOhtb8%3D 12720548 (Pubitemid 36981081)
38. K Shibao H Izumi Y Nakayama R Ohta N Nagata M Nomoto K Matsuo Y Yamada K Kitazato H Itoh K Kohno 2002 Expression of UDP-N-acetyl-alpha-D-galactosamine- polypeptide galNAc N-acetylgalactosaminyl transferase-3 in relation to differentiation and prognosis in patients with colorectal carcinoma Cancer. 94 1939 1946 10.1002/cncr.10423 1:CAS:528:DC%2BD38XjsVCns7Y%3D 11932895 (Pubitemid 34270046)
39. K Onitsuka K Shibao Y Nakayama N Minagawa K Hirata H Izumi K Matsuo N Nagata K Kitazato K Kohno H Itoh 2003 Prognostic significance of UDP-N-acetyl-alpha-D-galactosamine:polypeptide N- acetylgalactosaminyltransferase-3 (GalNAc-T3) expression in patients with gastric carcinoma Cancer Sci. 94 32 36 10.1111/j.1349-7006.2003.tb01348.x 1:CAS:528:DC%2BD3sXisFektb8%3D 12708471 (Pubitemid 36575855)
40. SA Brooks TM Carter EP Bennett H Clausen U Mandel 2007 Immunolocalisation of members of the polypeptide N-acetylgalactosaminyl transferase (ppGalNAc-T) family is consistent with biologically relevant altered cell surface glycosylation in breast cancer Acta Histochem. 109 273 284 10.1016/j.acthis. 2007.02.009 1:CAS:528:DC%2BD2sXhtVWqtr3F 17448526 (Pubitemid 46962083)
41. O Topaz DL Shurman R Bergman M Indelman P Ratajczak M Mizrachi Z Khamaysi D Behar D Petronius V Friedman I Zelikovic S Raimer A Metzker G Richard E Sprecher 2004 Mutations in GALNT3, encoding a protein involved in O-linked glycosylation, cause familial tumoral calcinosis Nat Genet. 36 579 581 10.1038/ng1358 1:CAS:528:DC%2BD2cXksVajt78%3D 15133511 (Pubitemid 38715983)
42. K Kato C Jeanneau MA Tarp A Benet-Pages B Lorenz-Depiereux EP Bennett U Mandel TM Strom H Clausen 2006 Polypeptide GalNAc-transferase T3 and familial tumoral calcinosis. Secretion of fibroblast growth factor 23 requires O-glycosylation J Biol Chem. 281 18370 18377 10.1074/jbc.M602469200 1:CAS:528:DC%2BD28XmsVagsbg%3D 16638743 (Pubitemid 44035494)
43. Y Frishberg N Ito C Rinat Y Yamazaki S Feinstein I Urakawa P Navon-Elkan R Becker-Cohen T Yamashita K Araya T Igarashi T Fujita S Fukumoto 2007 Hyperostosis-hyperphosphatemia syndrome: a congenital disorder of O-glycosylation associated with augmented processing of fibroblast growth factor 23 J Bone Miner Res. 22 235 242 10.1359/jbmr.061105 1:CAS:528: DC%2BD2sXhvFCgs7w%3D 17129170 (Pubitemid 46167794)