Abnormal hemoglobins among Kurdish population of Western Iran: Hematological and molecular features

Molecular Biology Reports

Volumn 37, Issue 1, 2010, Pages 51-57

  Rahimi, Zohreh ^a,b   Muniz, Adriana ^c   Mozafari, Hadi ^a  

^a KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b KERMANSHAH UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

S gene; Haplotype; Hb D Punjab; Hb Q Iran; Hb Setif; Western Iran

Indexed keywords

BETA GLOBIN; HEMOGLOBIN C; HEMOGLOBIN D; HEMOGLOBIN Q; HEMOGLOBIN S; HEMOGLOBIN SETIF; HEMOGLOBIN VARIANT; UNCLASSIFIED DRUG;

ADOLESCENT; ALPHA CHAIN; ARTICLE; BENIN; BETA THALASSEMIA; CHILD; CHROMOSOME; FAMILY; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE MUTATION; GENE SEQUENCE; GENETIC LINKAGE; GENETIC VARIABILITY; HAPLOTYPE; HEMATOLOGICAL PARAMETERS; HETEROZYGOSITY; HETEROZYGOTE; HUMAN; IRAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRESCHOOL CHILD; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCREENING; SICKLE CELL ANEMIA;

ETHNIC GROUPS; HEMATOLOGIC TESTS; HEMOGLOBINS, ABNORMAL; HETEROZYGOTE; HOMOZYGOTE; HUMANS; IRAN;

EID: 77949261644     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-009-9516-4     Document Type: Article

References (36)

1. Weatherall DJ, Clegg JB, Higgs DR, Wood WG (1995) The hemoglobinopathies. In: Sriver CR, Beadet AL, Sly WS, Valle D (eds) The metabolic and molecular basis of inherited disease, vol 3. McGraw-Hill Inc., New York, pp 3417-3484
2. Z Rahimi A Merat M Haghshenass H Madani M Rezaei RL Nagel 2006 Plasma lipids in Iranians with sickle cell disease: hypocholesterolemia in sickle cell anemia and increase of HDL cholesterol in sickle cell trait Clin Chim Acta 365 217 220 10.1016/j.cca.2005.08.022 10.1016/j.cca.2005.08.022 1:CAS:528: DC%2BD28XhtFaqsbg%3D 16185676 (Pubitemid 43204005)
3. S gene in Central Iran is in linkage disequilibrium with the Indian-Arab haplotype Am J Hematol 65 192 195 10.1002/1096-8652(200011)65:3<192::AID-AJH3>3.0.CO;2-N 10.1002/1096-8652(200011)65:3<192::AID-AJH3>3.0.CO;2-N 1:CAS:528:DC%2BD3cXnvV2ltbk%3D 11074534 (Pubitemid 30783089)
4. Y Niranjan GR Chandak P Veerraju L Singh 1999 Some atypical and rare sickle cell gene haplotypes in populations of Andhra Pradesh, India Hum Biol 71 3 333 340 1:STN:280:DyaK1MzgvFClug%3D%3D 10380370
5. J Pagnier JG Mears O Dunda-Belkhodja R Schaefer C Beldjord RL Nagel D Labie 1984 Evidence for the multicentric origin of the sickle hemoglobin gene in Africa Proc Natl Acad Sci USA 81 1771 1773 10.1073/pnas.81.6.1771 10.1073/pnas.81.6.1771 1:CAS:528:DyaL2cXhvV2ksLw%3D 6584911
6. C Lapoumeroulie O Dunda R Ducrocq G Trabuchet M Mony-Lobe JM Bodo, et al. 1992 A novel sickle mutation of yet another origin in Africa: the Cameroon type Hum Genet 89 333 337 1:STN:280:DyaK383ptVCkug%3D%3D 1376298
7. S mutation and the unicentric origin of the tribal populations of India Hum Biol 61 479 491 1:STN:280:DyaK3c%2FnslentA%3D%3D 2480325
8. Z Rahimi M Karimi M Haghshenass A Merat 2003 β-globin gene cluster haplotypes in sickle cell patients from Southwest Iran Am J Hematol 74 156 160 10.1002/ajh.10422 10.1002/ajh.10422 1:CAS:528:DC%2BD3sXpslGgur8%3D 14587041 (Pubitemid 37363011)
9. Brittenham GM (1987) Globin variants and polymorphism in India. In: Winter WP (ed) Hemoglobin variants in human populations, vol 2. CRC Press, Boca Raton, p 79
10. H Li X Zhao F Qin HW Li L Li X He X Chang Z Li K Liang K Xing F Xing W Chang R Wong I Yang F Li T Zhang, et al. 1990 Abnormal hemoglobin in the Silk Road region of China Hum Genet 86 231 235 10.1007/BF00197711 10.1007/BF00197711 1:STN:280:DyaK3M%2Fpt1Knsg%3D%3D 2265836
11. FJ Perea M Casas-Castaneda AR Villalobos-Arambula H Barajas F Alvarez A Camacho RM Hermosillo B Ibarra 1999 Hb D-Los Angeles associated with Hb S or β-thalassemia in four Mexican Mestizo families Hemoglobin 23 231 237 10.3109/03630269909005703 10.3109/03630269909005703 1:CAS:528:DyaK1MXlvVSktLc%3D 10490135
12. G Fioretti M De Angioletti G Pagano G Lacerra A Viola C de Bonis A Scarallo C Carestia 1993 DNA polymorphisms associated with Hb D-Los Angeles [β121 (GH4) Glu → Gln] in Southern Italy Hemoglobin 17 9 17 10.3109/03630269308998881 10.3109/03630269308998881 1:STN:280: DyaK3s3gt12ntw%3D%3D 8095930
13. Z Rahimi R Akramipour RL Nagel AS Ahmadi A Merat F Bahrehmand 2006 The beta-globin gene haplotypes associated with Hb D-Los Angeles [beta121 (GH4)Glu → Gln] in Western Iran Hemoglobin 30 39 44 10.1080/03630260500454105 10.1080/03630260500454105 1:CAS:528:DC%2BD28XisVartLs%3D 16540414
14. PA Lorkin D Charlesworth H Lehmann S Rahbar S Tuchinda LE Lie-Injo 1970 Two haemoglobins Q, α74 (EF3) and α 75 (EF4) Aspartic acid → histidine Br J Haematol 19 117 125 10.1111/j.1365-2141.1970.tb01607.x 10.1111/j.1365-2141.1970.tb01607.x 1:CAS:528:DyaE3cXkvFKms7o%3D 5460202
15. G Nozari S Rahbar P Darbre H Lehmann 1977 Hb Setif [α94 (G1) Asp → Tyr] in Iran: a report of 9 cases Hemoglobin 1 289 292 10.3109/03630267709003412 10.3109/03630267709003412 1:CAS:528:DyaE2sXhvVOit70%3D 893131
16. H Wajcman O Belkhodja D Labie 1972 Hb Setif: G1 (94) α Asp → Tyr a new α chain hemoglobin variant with substitution of the residue involved in a hydrogen bond between unlink subunits FEBS Lett 27 298 300 10.1016/0014-5793(72)80645-8 10.1016/0014-5793(72)80645-8 1:CAS:528: DyaE3sXptl2hsA%3D%3D 4667378
17. S Charache E Raik D Holtzclaw PJ Hathaway E Powell P Fleming 1987 Pseudosickling of hemoglobin Setif Blood 70 237 242 1:CAS:528:DyaL2sXlsFait7k%3D 3593966
18. R Abraham M Thomas R Britt C Fisher J Old 2003 Hb Q-India: an uncommon variant diagnosed in three Punjabi patients with diabetes is identified by a novel DNA analysis test J Clin Pathol 56 296 299 10.1136/jcp.56.4.296 10.1136/jcp.56.4.296 1:STN:280:DC%2BD3s7kslGgug%3D%3D 12663643 (Pubitemid 36459801)
19. Soltani MA (1999) Historical geography and comprehensive history of Kermanshah. Soha Press, Tehran
20. Fairbanks VF, Klee GG (1994) Biochemical aspects of hematology. In: Burtis CA, Ashwood ER (eds) Tietz text book of clinical chemistry. W. B Saunders, Philadelphia, pp 2041-2042
21. K Betke HR Marti I Schlicht 1959 Estimation of small percentages of foetal haemoglobin Nature 184 1877 1888 10.1038/1841877a0 10.1038/1841877a0 1:CAS:528:DyaF3cXnsFSnsA%3D%3D 13800165
22. Old JM, Higgs DR (1983) Gene analysis. In: Weatherall DJ (ed) Methods in hemotology. The thalassemias, vol 6. Churchill Livingstone, London, pp 74-101
23. Old JM (1996) Hemoglobinopathies. In: Elles R (ed) Methods in molecular medicine: molecular diagnosis of genetic disease. Humana Press Inc, Totowa, pp 169-183
24. EO Atalay H Koyuncu B Turgut A Atalay S Yildiz A Bahadir A Koseler 2005 High incidence of Hb D-Los Angeles [β121(GH4)Glu → Gln] in Denizli Province, Aegean region of Turkey Hemoglobin 29 307 310 10.1080/ 03630260500311685 10.1080/03630260500311685 1:CAS:528:DC%2BD2MXhtlSntLbJ 16370495 (Pubitemid 41780135)
25. Rezaei M, Ghomaicy AK (1998) Epidemiology of malaria in Kermanshah province of Iran 1987-96. 9th international congress of parasitology (ICOPA IX), Japan, O-0186. p 160
26. S Fucharoen Y Changtrakun S Surapot G Fucharoen K Sanchaisuriya 2002 Molecular characterization of Hb D-Punjab [β121(GH4)Glu → Gln] in Thailand Hemoglobin 26 261 269 10.1081/HEM-120015030 10.1081/HEM-120015030 1:CAS:528:DC%2BD38XotFektrs%3D 12403491 (Pubitemid 35191306)
27. EO Atalay A Atalay E Üstel S Yildiz O Öztürk A Köseler A Bahadir 2007 Genetic origin of Hb D-Los Angeles [β121(GH4) Glu → Gln, GAA → CAA] according to the β-globin gene cluster haplotypes Hemoglobin 31 387 391 10.1080/03630260701459416 10.1080/ 03630260701459416 1:CAS:528:DC%2BD2sXotFSjt7s%3D 17654078 (Pubitemid 47123786)
28. S globin gene. In: Stamatoyannopoules G, Nienhuis A (eds) Hemoglobin switching, part B: cellular and molecular mechanisms. Alen R. Liss Inc., New York, pp 371-393
29. S gene in Sicily is in linkage disequilibrium with the Benin haplotype: implications for gene flow Am J Hematol 27 139 141 10.1002/ajh.2830270214 10.1002/ajh.2830270214 1:STN:280:DyaL1c7jtFSjtg%3D%3D 2893541
30. Bernard L (1990) Race and slavery in the Middle East: an historical enquiry. Oxford University Press, Oxford
31. Z Rahimi A Merat N Gerard R Krishnamoorthy RL Nagel 2006 Implications of the genetic epidemiology of globin haplotypes linked to the sickle gene in Southern Iran Hum Biol 78 719 731 10.1353/hub.2007.0016 10.1353/hub.2007.0016 17564250
32. Forget BG, Pearson HA (1995) Hemoglobin synthesis and the Thalassemias. In: Handin RI, Lux SE, Stossel TP (eds) Blood: principles and practice of hematology. JB. Lippincott Company, Philadelphia, pp 1525-1590
33. Z Rahimi A Muniz R Akramipour F Tofieghzadeh H Mozafari A Vaisi-Raygani A Parsian 2009 Haplotype analysis of beta thalassemia in Western Iran Blood Cells Mol Dis 42 140 143 10.1016/j.bcmd.2008.12.001 10.1016/j.bcmd.2008.12.001 1:CAS:528:DC%2BD1MXhsFKrt78%3D 19141369
34. Dacie JV, Lewis SM (1999) Practical hematology, 8th edn. Churchill livingstone, London, pp 9-19
35. Z Rahimi M Rezaei RL Nagel A Muniz 2008 Molecular and hematologic analysis of hemoglobin Q-Iran and hemoglobin Setif in Iranian families Arch Iran Med 11 382 386 1:CAS:528:DC%2BD1cXhsVaqt7rK 18588369
36. R Akramipour M Rezaei Z Rahimi 2008 Prevalence of iron deficiency anemia among adolescent schoolgirls from Kermanshah, Western Iran Hematology 13 352 355 10.1179/102453308X343383 10.1179/102453308X343383 1:CAS:528: DC%2BD1MXhsFSms70%3D 19055864