ST2: A novel remodeling biomarker in acute and chronic heart failure

Current Heart Failure Reports

Volumn 7, Issue 1, 2010, Pages 9-14

  Shah, Ravi V ^a   Januzzi Jr , James L ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Biomarker; Heart failure; Prognosis; Remodeling

Indexed keywords

AMINO TERMINAL PRO BRAIN NATRIURETIC PEPTIDE; BIOLOGICAL MARKER; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 33; PROTEIN ST2; UNCLASSIFIED DRUG;

ACUTE CORONARY SYNDROME; ACUTE HEART FAILURE; ACUTE HEART INFARCTION; CARDIOVASCULAR RISK; CENTRAL VENOUS PRESSURE; CLINICAL TRIAL; DISEASE SEVERITY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE SIZE; HEART LEFT VENTRICLE VOLUME; HEART RATE; HEART RIGHT VENTRICLE EJECTION FRACTION; HUMAN; MORTALITY; NONHUMAN; PATHOPHYSIOLOGY; PATIENT MONITORING; PROGNOSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; SYSTOLIC BLOOD PRESSURE;

ACUTE CORONARY SYNDROME; ANIMALS; BIOLOGICAL MARKERS; HEART FAILURE; HUMANS; RECEPTORS, CELL SURFACE; RECEPTORS, INTERLEUKIN; RISK FACTORS; SEVERITY OF ILLNESS INDEX; VENTRICULAR REMODELING;

EID: 77949261472     PISSN: 15469530     EISSN: 15469549     Source Type: Journal    
DOI: 10.1007/s11897-010-0005-9     Document Type: Review

References (27)

1. L Daniels AS Maisel 2007 Natriuretic peptides J Am Coll Cardiol 50 2357 2368 10.1016/j.jacc.2007.09.021 1:CAS:528:DC%2BD2sXhsVOrtL7O 18154959 (Pubitemid 50011582)
2. F Liang DG Gardner 1999 Mechanical strain activates BNP gene transcription through a p38/NF-κB-dependent mechanism J Clin Invest 101 1603 1612 10.1172/JCI7362
3. GC Fonarow WF Peacock CO Phillips, et al. 2007 Admission B-type natriuretic peptide levels and in-hospital mortality in acute decompensated heart failure J Am Coll Cardiol 49 1943 1950 10.1016/j.jacc.2007.02.037 1:CAS:528:DC%2BD2sXlt1amtLw%3D 17498579 (Pubitemid 46694287)
4. AA Chen MJ Wood DG Krauser, et al. 2006 NT-proBNP levels, echocardiographic findings, and outcomes in breathless patients: results from the ProBNP Investigation of Dyspnea in the Emergency Department (PRIDE) echocardiographic substudy Eur Heart J 27 839 845 10.1093/eurheartj/ehi811 1:CAS:528:DC%2BD28XjvFOntLY%3D 16510467
5. P Bettencourt S Ferreira A Azevedo A Ferreira 2002 Preliminary data on the potential usefulness of B-type natriuretic peptide levels in predicting outcome after hospital discharge in patients with heart failure Am J Med 113 215 219 10.1016/S0002-9343(02)01184-1 1:CAS:528:DC%2BD38Xms1yntL8%3D 12208380 (Pubitemid 35245630)
6. D Logeart G Thabut P Jourdain, et al. 2004 Predischarge B-type natriuretic peptide assay for identifying patients at high risk for re-admission after decompensated heart failure J Am Coll Cardiol 43 635 641 10.1016/j.jacc.2003.09.044 1:CAS:528:DC%2BD2cXitlaqsbY%3D 14975475 (Pubitemid 38229537)
7. EO Weinberg M Shimpo GW De Keulenaer, et al. 2002 Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction Circulation 106 2961 2966 10.1161/01.CIR.0000038705. 69871.D9 1:CAS:528:DC%2BD38XovVeltrY%3D 12460879 (Pubitemid 35424749)
8. MS Sabatine DA Morrow LJ Higgins, et al. 2008 Complementary roles for biomarkers of biomechanical strain ST2 and N-terminal prohormone B-type natriuretic peptide in patients with ST-elevation myocardial infarction Circulation 117 1936 1944 10.1161/CIRCULATIONAHA.107.728022 1:CAS:528: DC%2BD1cXktl2gsb0%3D 18378613 (Pubitemid 351543469)
9. M Shimpo DA Morrow EO Weinberg, et al. 2004 Serum levels of the interleukin-1 receptor family member ST2 predict mortality and clinical outcome in acute myocardial infarction Circulation 109 2186 2190 10.1161/01.CIR. 0000127958.21003.5A 1:CAS:528:DC%2BD2cXjs1eisrs%3D 15117853 (Pubitemid 38625395)
10. EO Weinberg M Shimpo S Hurwitz, et al. 2003 Identification of serum soluble ST2 receptor as a novel heart failure biomarker Circulation 107 721 726 10.1161/01.CIR.0000047274.66749.FE 12578875 (Pubitemid 36222600)
11. SU Rehman T Mueller JL Januzzi Jr 2008 Characteristics of the novel interleukin family biomarker ST2 in patients with acute heart failure J Am Coll Cardiol 52 1458 1465 10.1016/j.jacc.2008.07.042 1:CAS:528:DC%2BD1cXht12gt77K 19017513
12. JL Januzzi Jr WF Peacock AS Maisel, et al. 2007 Measurement of the interleukin family member ST2 in patients with acute dyspnea: results from the PRIDE study J Am Coll Cardiol 50 607 613 10.1016/j.jacc.2007.05.014 1:CAS:528:DC%2BD2sXovFyntro%3D 17692745 (Pubitemid 47199007)
13. T Myeller, et al. 2008 Increased plasma concentrations of soluble ST2 are predictive for 1-year mortality in patients with acute destabilized heart failure Clin Chem S4 752 756 10.1373/clinchem.2007.096560 (Pubitemid 351573718)
14. H Iwahana K Yanagisawa A Ito-Kosaka, et al. 1999 Different promoter usage and multiple transcription initiation sites of the interleukin-1 receptor-related human ST2 gene in UT-7 and TM12 cells Eur J Biochem 264 397 406 10.1046/j.1432-1327.1999.00615.x 1:CAS:528:DyaK1MXlvFWrsr0%3D 10491084 (Pubitemid 29424443)
15. AJ Coyle C Lloyd J Tian, et al. 1999 Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses J Exp Med 190 895 902 10.1084/jem.190.7.895 1:CAS:528:DyaK1MXmsVCltrs%3D 10510079 (Pubitemid 29480818)
16. S Sanada D Hakuno LJ Higgins, et al. 2007 IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system J Clin Invest 117 1538 1549 10.1172/JCI30634 1:CAS:528:DC%2BD2sXmsVWkur4%3D 17492053 This report extensively details the relationship between ST2 and IL-33 in in vitro and in vivo model, providing a potential mechanism for elevated ST2 concentrations in adverse cardiac remodeling. (Pubitemid 46871338)
17. K Seki S Sanada AY Kudinova, et al. 2009 Interleukin-33 prevents apoptosis and improves survival after experimental myocardial infarction through ST2 signaling Circ Heart Fail 2 684 691 10.1161/CIRCHEARTFAILURE.109.873240 1:CAS:528:DC%2BD1MXhtlyqsb7I 19919994
18. T Mueller B Dieplinger A Gegenhuber, et al. 2008 Increased plasma concentrations of soluble ST2 are predictive for 1-year mortality in patients with acute destabilized heart failure Clin Chem S4 752 756 10.1373/clinchem. 2007.096560 (Pubitemid 351573718)
19. RV Shah AA Chen-Tournoux MH Picard, et al. 2009 Serum levels of the interleukin- 1 receptor family member ST2, cardiac structure and function, and long-term mortality in patients with acute dyspnea Circulation: Heart Failure 2 311 319 10.1161/CIRCHEARTFAILURE.108.833707 1:CAS:528:DC%2BD1MXotFWmu78%3D
20. A Bayés-Genís M Santaló-Bel E Zapico-Muñiz, et al. 2004 N-terminal pro-brain natriuretic peptide (NT-proBNP) in the emergency diagnosis and in-hospital monitoring of patients with dyspnoea and ventricular dysfunction Eur J Heart Fail 6 301 308 10.1016/j.ejheart.2003.12.013 14987580 (Pubitemid 38253049)
21. P Jourdain G Jondeau F Funck, et al. 2007 Plasma brain natriuretic peptide-guided therapy to improve outcome in heart failure: the STARS-BNP Multicenter Study J Am Coll Cardiol 49 1733 1739 10.1016/j.jacc.2006.10.081 1:CAS:528:DC%2BD2sXksFWqtbg%3D 17448376 (Pubitemid 46589928)
22. M Pfisterer P Buser H Rickli, et al. 2009 BNP-guided vs symptom-guided heart failure therapy: the Trial of Intensified vs Standard Medical Therapy in Elderly Patients With Congestive Heart Failure (TIME-CHF) randomized trial JAMA 301 383 392 10.1001/jama.2009.2 1:CAS:528:DC%2BD1MXhtlWgsbw%3D 19176440
23. Shah M: STARBRITE: A randomized pilot trial of BNP-guided therapy in patients with advanced heart failure. Circulation 2006, 114:II528.
24. RW Troughton CM Frampton TG Yandle, et al. 2000 Treatment of heart failure guided by plasma aminoterminal brain natriuretic peptide (N-BNP) concentrations Lancet 355 1126 1130 10.1016/S0140-6736(00)02060-2 1:CAS:528:DC%2BD3cXislegsr0%3D 10791374
25. S Boisot, et al. 2008 Serial sampling of ST2 predicts 90-day mortality following destabilized heart failure J Card Fail 14 732 738 10.1016/j.cardfail. 2008.06.415 18995177
26. J Bartunek L Delrue F Van Durme, et al. 2008 Nonmyocardial production of ST2 protein in human hypertrophy and failure is related to diastolic load J Am Coll Cardiol 52 2166 2174 10.1016/j.jacc.2008.09.027 1:CAS:528: DC%2BD1cXhsFajs7rP 19095135
27. B Dieplinger JL Januzzi Jr M Steinmair, et al. 2009 Analytical and clinical evaluation of a novel high-sensitivity assay for measurement of soluble ST2 in human plasma-The Presage ST2 assay Clinica Chimica Acta 409 33 40 10.1016/j.cca.2009.08.010 1:CAS:528:DC%2BD1MXht1aju77I This report details a novel, high-sensitivity assay used to measure ST2 concentrations.