Aquaglyceroporins are involved in uptake of arsenite into murine gastrointestinal tissues

Journal of Medical Investigation

Volumn 56, Issue SUPPL. 1, 2009, Pages 343-346

  Wang, Chun ^a   Chen, Gang ^a   Jiang, Junkang ^a   Qiu, Lianglin ^a   Hosoi, Kazuo ^b   Yao, Chenjuan ^a,b  

^a NANTONG UNIVERSITY   (China)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Aquaglyceroporins (AQGPs); Arsenite; Gastrointestinal tissues

Indexed keywords

AQUAGLYCEROPORIN; ARSENIC; ARSENIC TRIOXIDE; GLYCEROL; INORGANIC COMPOUND; MERCURY;

ANIMAL EXPERIMENT; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; GASTROINTESTINAL ABSORPTION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; AQUAGLYCEROPORINS; ARSENITES; BIOLOGICAL TRANSPORT; CELL LINE; GASTROINTESTINAL TRACT; GLYCEROL; HUMANS; MALE; MERCURY; MICE; MICE, INBRED ICR; SIGNAL TRANSDUCTION;

MAMMALIA; MURINAE; MUS;

EID: 77749322499     PISSN: 13431420     EISSN: None     Source Type: Journal    
DOI: 10.2152/jmi.56.343     Document Type: Conference Paper

References (14)

1. Lee TC, Ho IC, Lu WJ, Huang JD: Enhanced expression of multidrug resistance-associated protein 2 and reduced expression of aquaglyceroporin 3 in an arsenic-resistant human cell line. J Biol Chem 281: 18401-18407, 2006
2. Chen Z, Chen GQ, Shen ZX, Sun GL, Tong JH, Wang ZY, Chen SJ: Expanding the use of arsenic trioxide: leukemias and beyond. Semin Hematol 39: 22-26, 2002
3. Porquet A, Filella M: Structural evidence of the similarity of Sb(OH)3 and As(OH)3 with glycerol: implications for their uptake. Chem Res Toxicol 20: 1269-1276, 2007
4. Bienert GP, Schussler MD, Jahn TP: Metalloids: essential, beneficial or toxic? Major intrinsic proteins sort it out. Trends Biochem Sci 33: 20-26, 2008
5. Sanders OI, Rensing C, Kuroda M, Mitra B, Rosen BP: Antimonite is accumulated by the glycerol facilitator GIpF in Escherichia coli. J Bacteriol 79: 3365-3367, 1997
6. Wysocki R, Chery CC, Wawrzycka D, Van Hulle M, Cornelis R, Thevelein JM, Tamas MJ: The glycerol channel Fps1p mediates the uptake of arsenite and antimonite in Saccharomyces cerevisias. Mol Microbiol 40: 1391-1401, 2001
7. Liu Z, Shen J, Carbrey JM, Mukhopadhyay R, Agre P, Rosen BP: Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. Proc Natl Acad Sci 99: 6053-6058, 2002
8. Liu Z, Carbrey JM, Agre P, Rosen BP: Arsenic trioxide uptake by human and rat aquaglyceroporins. Biochem Biophys Res Commun 316: 1178-1185, 2004
9. Shinkai Y, Sumi D, Toyama T, Kaji T, Kumagai Y: Role of aquaporin 9 in cellular accumulation of arsenic and its cytotoxicity in primary mouse hepatocytes. Toxicol Appl Pharmacol 237: 232-236, 2009
10. Bhattacharjee H, Carbrey J, Rosen BP, Mukhopadhyay R: Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9. Biochem Biophys Res Commun 322: 836-841, 2004
11. Leung J, Pang A, Yuen WH, Kwong YL, Tse EW: Relationship of expression of aquaglyceroporin 9 with arsenic uptake and sensitivity in leukemia cells. Blood 109: 740-746, 2007
12. Antimisiaris SG, Klepetsanis P, Zachariou V, Giannopoulou E, Ioannou PV: In vivo distribution of arsenic after i.p. injection of arsonoliposomes in balb - c mice. Int J Pharm 289: 151-158, 2005
13. Hara-Chikuma M, Verkman AS: Physiological roles of glycerol-transporting aquaporins: the aquaglyceroporins. Cell Mol Life Sci 63: 1386-1392, 2006
14. Agre P, Kozono D: Aquaporin water channels: molecular mechanisms for human diseases. FEBS Lett 555: 72-78, 2003