메뉴 건너뛰기




Volumn 17, Issue SUPPL. 1, 2010, Pages 59-65

Virological response to antiviral therapy at week 12 indicates a great reduction of intrahepatic hepatitis B virus DNA and cccDNA in HBeAg-positive chronic hepatitis B patients

Author keywords

Covalently closed circular DNA; Hepatitis B virus; Interferon 2b; Lamivudine; Virological response

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALPHA2B INTERFERON; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; CIRCULAR DNA; COVALENTLY CLOSED CIRCULAR DNA; HEPATITIS B(E) ANTIGEN; LAMIVUDINE; UNCLASSIFIED DRUG; VIRUS DNA;

EID: 77749308549     PISSN: 13520504     EISSN: 13652893     Source Type: Journal    
DOI: 10.1111/j.1365-2893.2010.01272.x     Document Type: Article
Times cited : (7)

References (29)
  • 1
    • 77951440698 scopus 로고    scopus 로고
    • World Health Organization. Geneva. World Health Organization
    • World Health Organization. Fact sheets WHO/204: Hepatitus B. Geneva : World Health Organization, 2000.
    • (2000) Fact Sheets WHO/204: Hepatitus B.
  • 2
    • 0035010523 scopus 로고    scopus 로고
    • Management of hepatitis B: 2000 - Summary of a workshop
    • Lok AS, Heathcote EJ, Hoofnagle JH. Management of hepatitis B: 2000 - summary of a workshop. Gastroenterology 2001 120 : 1828 1853.
    • (2001) Gastroenterology , vol.120 , pp. 1828-1853
    • Lok, A.S.1    Heathcote, E.J.2    Hoofnagle, J.H.3
  • 3
    • 21244447705 scopus 로고    scopus 로고
    • Peginterferon alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B
    • Lau GK, Piratvisuth T, Luo KX et al. Peginterferon alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B. N Engl J Med 2005 352 : 2682 2695.
    • (2005) N Engl J Med , vol.352 , pp. 2682-2695
    • Lau, G.K.1    Piratvisuth, T.2    Luo, K.X.3
  • 4
    • 4544239807 scopus 로고    scopus 로고
    • Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B
    • Marcellin P, Lau GK, Bonino F et al. Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B. N Engl J Med 2004 351 : 1206 1217.
    • (2004) N Engl J Med , vol.351 , pp. 1206-1217
    • Marcellin, P.1    Lau, G.K.2    Bonino, F.3
  • 5
    • 0033592764 scopus 로고    scopus 로고
    • Lamivudine as initial treatment for chronic hepatitis B in the United States
    • Dienstag JL, Schiff ER, Wright TL et al. Lamivudine as initial treatment for chronic hepatitis B in the United States. N Engl J Med 1999 341 : 1256 1263.
    • (1999) N Engl J Med , vol.341 , pp. 1256-1263
    • Dienstag, J.L.1    Schiff, E.R.2    Wright, T.L.3
  • 6
    • 21244455293 scopus 로고    scopus 로고
    • Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B
    • Hadziyannis SJ, Tassopoulos NC, Heathcote EJ et al. Long-term therapy with adefovir dipivoxil for HBeAg-negative chronic hepatitis B. N Engl J Med 2005 352 : 2673 2681.
    • (2005) N Engl J Med , vol.352 , pp. 2673-2681
    • Hadziyannis, S.J.1    Tassopoulos, N.C.2    Heathcote, E.J.3
  • 7
    • 33644818518 scopus 로고    scopus 로고
    • A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B
    • Chang TT, Gish RG, de Man R et al. A comparison of entecavir and lamivudine for HBeAg-positive chronic hepatitis B. N Engl J Med 2006 354 : 1001 1010.
    • (2006) N Engl J Med , vol.354 , pp. 1001-1010
    • Chang, T.T.1    Gish, R.G.2    De Man, R.3
  • 8
    • 33644822860 scopus 로고    scopus 로고
    • Entecavir versus lamivudine mfor patients with HBeAg-negative chronic hepatitis B
    • Lai CL, Shouval D, Lok AS et al. Entecavir versus lamivudine mfor patients with HBeAg-negative chronic hepatitis B. N Engl J Med 2006 354 : 1011 1020.
    • (2006) N Engl J Med , vol.354 , pp. 1011-1020
    • Lai, C.L.1    Shouval, D.2    Lok, A.S.3
  • 9
    • 59149090874 scopus 로고    scopus 로고
    • On-treatment monitoring of adefovir therapy in chronic hepatitis B: Virologic response can be assessed at 24 weeks
    • Reijnders JG, Leemans WF, Hansen BE et al. On-treatment monitoring of adefovir therapy in chronic hepatitis B: virologic response can be assessed at 24 weeks. J Viral Hepat 2009 16 (2 113 120.
    • (2009) J Viral Hepat , vol.16 , Issue.2 , pp. 113-120
    • Reijnders, J.G.1    Leemans, W.F.2    Hansen, B.E.3
  • 10
    • 58949087420 scopus 로고    scopus 로고
    • Early hepatitis B virus DNA reduction in hepatitis B e antigen-positive patients with chronic hepatitis B: A randomized international study of entecavir versus adefovir
    • Leung N, Peng CY, Hann HW et al. Early hepatitis B virus DNA reduction in hepatitis B e antigen-positive patients with chronic hepatitis B: a randomized international study of entecavir versus adefovir. Hepatology 2009 49 (1 72 79.
    • (2009) Hepatology , vol.49 , Issue.1 , pp. 72-79
    • Leung, N.1    Peng, C.Y.2    Hann, H.W.3
  • 11
    • 50649112802 scopus 로고    scopus 로고
    • Treatment predictors of a sustained virologic response in hepatitis B and C
    • Kau A, Vermehren J, Sarrazin C. Treatment predictors of a sustained virologic response in hepatitis B and C. J Hepatol 2008 49 (4 634 651.
    • (2008) J Hepatol , vol.49 , Issue.4 , pp. 634-651
    • Kau, A.1    Vermehren, J.2    Sarrazin, C.3
  • 12
    • 0032736596 scopus 로고    scopus 로고
    • Integration of hepadnavirus DNA in infected liver: Evidence for a linear precursor
    • Yang W, Summers J. Integration of hepadnavirus DNA in infected liver: evidence for a linear precursor. J Virol 1999 73 : 9710 9717.
    • (1999) J Virol , vol.73 , pp. 9710-9717
    • Yang, W.1    Summers, J.2
  • 13
    • 13844250599 scopus 로고    scopus 로고
    • New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA
    • Zoulim F. New insight on hepatitis B virus persistence from the study of intrahepatic viral cccDNA. J Hepatol 2005 42 : 302 308.
    • (2005) J Hepatol , vol.42 , pp. 302-308
    • Zoulim, F.1
  • 14
    • 19144371967 scopus 로고    scopus 로고
    • Effect of lamivudine therapy on the serum covalently closed-circular (ccc) DNA of chronic hepatitis B infection
    • Yuen MF, Wong DK, Sum SS et al. Effect of lamivudine therapy on the serum covalently closed-circular (ccc) DNA of chronic hepatitis B infection. Am J Gastroenterol 2005 100 (5 1099 1103.
    • (2005) Am J Gastroenterol , vol.100 , Issue.5 , pp. 1099-1103
    • Yuen, M.F.1    Wong, D.K.2    Sum, S.S.3
  • 15
    • 2942532722 scopus 로고    scopus 로고
    • Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy
    • Werle-Lapostolle B, Bowden S, Locarnini S et al. Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology 2004 126 (7 1750 1758.
    • (2004) Gastroenterology , vol.126 , Issue.7 , pp. 1750-1758
    • Werle-Lapostolle, B.1    Bowden, S.2    Locarnini, S.3
  • 16
    • 33750964835 scopus 로고    scopus 로고
    • One-year entecavir or lamivudine therapy results in reduction of hepatitis B virus intrahepatic covalently closed circular DNA levels
    • Wong DK, Yuen MF, Ngai VW, Fung J, Lai CL. One-year entecavir or lamivudine therapy results in reduction of hepatitis B virus intrahepatic covalently closed circular DNA levels. Antivir Ther 2006 11 (7 909 911.
    • (2006) Antivir Ther , vol.11 , Issue.7 , pp. 909-911
    • Wong, D.K.1    Yuen, M.F.2    Ngai, V.W.3    Fung, J.4    Lai, C.L.5
  • 17
    • 40549140790 scopus 로고    scopus 로고
    • Effects of antiviral agents and HBV genotypes on intrahepatic ccc DNA in HBeAg-positive chronic hepatitis B patients
    • Lu HY, Zhuang LW, Yu YY, Si CW, Zeng Z, Li J. Effects of antiviral agents and HBV genotypes on intrahepatic ccc DNA in HBeAg-positive chronic hepatitis B patients. World J Gastroenterol 2008 14 (8 1268 1273.
    • (2008) World J Gastroenterol , vol.14 , Issue.8 , pp. 1268-1273
    • Lu, H.Y.1    Zhuang, L.W.2    Yu, Y.Y.3    Si, C.W.4    Zeng, Z.5    Li, J.6
  • 18
    • 0019813866 scopus 로고
    • Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis
    • Knodell RG, Ishak KG, Black WC et al. Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology 1981 1 : 431 435.
    • (1981) Hepatology , vol.1 , pp. 431-435
    • Knodell, R.G.1    Ishak, K.G.2    Black, W.C.3
  • 19
    • 0027378724 scopus 로고
    • Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. A metaanalysis
    • Wong DK, Cheung AM, O'Rourke K, Naylor CD, Detsky AS, Heathcote J. Effect of alpha-interferon treatment in patients with hepatitis B e antigen-positive chronic hepatitis B. A metaanalysis. Ann Intern Med 1993 119 : 312 323.
    • (1993) Ann Intern Med , vol.119 , pp. 312-323
    • Wong, D.K.1    Cheung, A.M.2    O'Rourke, K.3    Naylor, C.D.4    Detsky, A.S.5    Heathcote, J.6
  • 20
    • 0038045171 scopus 로고    scopus 로고
    • Peginterferon alpha-2a (40 kDa): An advance in the treatment of hepatitis B e entigen-positive chronic hepatitis B
    • Cooksley WG, Piratvisuth T, Lee SD et al. Peginterferon alpha-2a (40 kDa): an advance in the treatment of hepatitis B e entigen-positive chronic hepatitis B. J Viral Hepat 2003 10 : 298 305.
    • (2003) J Viral Hepat , vol.10 , pp. 298-305
    • Cooksley, W.G.1    Piratvisuth, T.2    Lee, S.D.3
  • 21
    • 51049107683 scopus 로고    scopus 로고
    • Asian-Pacific consensus statement on the management of chronic hepatitis B: A 2008 update
    • Liaw Y-F, Leung N, Kao J-H et al. Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2008 update. Hepatol Int 2008 2 : 263 283.
    • (2008) Hepatol Int , vol.2 , pp. 263-283
    • Liaw, Y.-F.1    Leung, N.2    Kao, J.-H.3
  • 22
    • 51049114985 scopus 로고    scopus 로고
    • Recent data on treatment of chronic hepatitis B with nucleos(t)ide analogues
    • Leung N. Recent data on treatment of chronic hepatitis B with nucleos(t)ide analogues. Hepatol Int 2008 2 : 163 178.
    • (2008) Hepatol Int , vol.2 , pp. 163-178
    • Leung, N.1
  • 23
    • 85121087121 scopus 로고    scopus 로고
    • Primary resistance, multidrug resistance and crossresistance pathways in HBV as a consequence of treatment failure
    • Locarnini S. Primary resistance, multidrug resistance and crossresistance pathways in HBV as a consequence of treatment failure. Hepatol Int 2008 10 : 9048 9053.
    • (2008) Hepatol Int , vol.10 , pp. 9048-9053
    • Locarnini, S.1
  • 24
    • 51049121362 scopus 로고    scopus 로고
    • The roadmap concept: Using early on-treatment virologic responses to optimize long-term outcomes for patients with chronic hepatitis B
    • Gane E. The roadmap concept: using early on-treatment virologic responses to optimize long-term outcomes for patients with chronic hepatitis B. Hepatol Int 2008 2 : 304 307.
    • (2008) Hepatol Int , vol.2 , pp. 304-307
    • Gane, E.1
  • 25
    • 34547148385 scopus 로고    scopus 로고
    • Report of an international workshop: Roadmap for management of patients receiving oral therapy for chronic hepatitis B
    • Keeffe EB, Zeuzem S, Koff RS et al. Report of an international workshop: roadmap for management of patients receiving oral therapy for chronic hepatitis B. Clin Gastroenterol Hepatol 2007 5 (8 890 897.
    • (2007) Clin Gastroenterol Hepatol , vol.5 , Issue.8 , pp. 890-897
    • Keeffe, E.B.1    Zeuzem, S.2    Koff, R.S.3
  • 26
    • 67349178133 scopus 로고    scopus 로고
    • Baseline characteristics and early on-treatment response predict the outcomes of 2 years telbivudine treatment of chronic hepatitis B
    • Zeuzem S, Gane E, Liaw Y-F et al. Baseline characteristics and early on-treatment response predict the outcomes of 2 years telbivudine treatment of chronic hepatitis B. J Hepatol 2009 51 (1 11 20.
    • (2009) J Hepatol , vol.51 , Issue.1 , pp. 11-20
    • Zeuzem, S.1    Gane, E.2    Liaw, Y.-F.3
  • 27
    • 34347385110 scopus 로고    scopus 로고
    • Prediction of treatment outcomes for lamivudine
    • Yuen M-F, Lai C-L. Prediction of treatment outcomes for lamivudine. J Gastroenterol Hepatol 2007 22 : 961 969.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. 961-969
    • Yuen, M.-F.1    Lai, C.-L.2
  • 28
    • 34047161559 scopus 로고    scopus 로고
    • Early virological suppression is associated with good maintained response to adefovir dipivoxil in lamivudine resistant chronic hepatitis B
    • Chan HL, Wong VW, Tse CH et al. Early virological suppression is associated with good maintained response to adefovir dipivoxil in lamivudine resistant chronic hepatitis B. Aliment Pharmacol Ther 2007 25 : 891 898.
    • (2007) Aliment Pharmacol Ther , vol.25 , pp. 891-898
    • Chan, H.L.1    Wong, V.W.2    Tse, C.H.3
  • 29
    • 37749021636 scopus 로고    scopus 로고
    • Hepatitis B virus DNA levels at week 4 of lamivudine treatment predict the 5-year ideal response
    • Yuen M-F, Fong DY-T, Wong DK-H, Yuen JC-H, Fung J, Lai C-L. Hepatitis B virus DNA levels at week 4 of lamivudine treatment predict the 5-year ideal response. Hepatology 2007 46 : 1695 1703.
    • (2007) Hepatology , vol.46 , pp. 1695-1703
    • Yuen, M.-F.1    Dy-T, F.2    Dk-H, W.3    Jc-H, Y.4    Fung, J.5    Lai, C.-L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.