Guanfacine overdose resulting in initial hypertension and subsequent delayed, persistent orthostatic hypotension

Clinical Toxicology

Volumn 48, Issue 2, 2010, Pages 146-148

  Minns, Alicia B ^a   Clark, Richard F ^a   Schneir, Aaron ^a  

^a University of California   (United States)

Author keywords

Adrenoreceptor; Cardiovascular; Imidazole; Poisoning; Tic disorders

Indexed keywords

ACTIVATED CARBON; GUANFACINE;

ADOLESCENT; ARTICLE; BLOOD PRESSURE; CASE REPORT; DIAPHORESIS; DRUG OVERDOSE; ELECTROCARDIOGRAM; EMERGENCY WARD; FEMALE; GILLES DE LA TOURETTE SYNDROME; HUMAN; HYPERTENSION; ORTHOSTATIC HYPOTENSION; QT INTERVAL; QT PROLONGATION; SYNCOPE; XEROSTOMIA;

ADOLESCENT; ADRENERGIC ALPHA-AGONISTS; BLOOD PRESSURE; ELECTROCARDIOGRAPHY; FEMALE; GUANFACINE; HUMANS; HYPERTENSION; HYPOTENSION, ORTHOSTATIC; OVERDOSE; TIME FACTORS; TOURETTE SYNDROME;

SYNCOPE;

EID: 77749298312     PISSN: 15563650     EISSN: 15569519     Source Type: Journal    
DOI: 10.3109/15563650903505174     Document Type: Article

References (12)

1. Scahill L, Chappell PB, Kim YS, Schultz RT, Katsovich L, Shepherd E, Arnsten AF, Cohen DJ, Leckman JF. A placebo-controlled study of guanfacine in the treatment of children with tic disorders and attention deficit hyperactivity disorder. Am J Psychiatry 2001; 158:1067-1074.
2. Kisicki JC, Fiske K, Lyne A. Phase I, double-blind, placebo-controlled, dose-escalation study of the effects on blood pressure of abrupt cessation versus taper down of guanfacine extended-release tablets in adults aged 19-24 years. Clin Ther 2007; 29(9):1967-1979.
3. McGrath JC, Klein-Schwartz W. Epidemiology and toxicity of pediatric guanfacine exposures. Ann Pharmacother 2002; 36:1698-1703.
4. Van Dyke MW, Bonace AL, Ellenhorn MJ. Guanfacine overdose in a pediatric patient. Vet Hum Toxicol 1990; 32(1):46-47.
5. Granier P, Arsac P, Debru JL. Intoxication par la guanfacine. Nouv Presse Med 1982; 11:1636-1637.
6. Sorkin EM, Heel RC. Guanfacine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the treatment of hypertension. Drugs 1986; 31(4):301-336.
7. Keitel JR. Pharmacokinetics and metabolism of guanfacine in man: A review. Br J Pharmacol 1980; 10:25S-32S.
8. King A, Harris P, Fritzell J, Kurland R. Syncope in children with Toilette's syndrome treated with guanfacine. Mov Disord 2006; 21(3):419-420.
9. Frisk-Holmberg M, Wibell L. Concentration-dependent blood pressure effects of guanfacine. Clin Pharmacol Ther 1986; 39(2):169-172.
10. Frye CB, Vance MA. Hypertensive crisis and myocardial infarction following massive clonidine overdose. Ann Pharmacother 2000; 34(5):611-615.
11. Barber ND, Reid JL. Comparison of the actions of centrally and peripherally administered clonidine and guanfacine in the rabbit: investigation of the differences. Br J Pharmacol 1982; 77:641-647.
12. Biederman J, Melmed RD, Patel A, McBurnett K, Konow J, Lyne A, Scherer N. A randomized, double-blind, placebo-controlled study of guanfacine extended release in children and adolescents with attention-deficit/hyperactivity disorder. Pediatrics 2008; 121:e73-e84.