The panton-valentine leukocidin is a virulence factor in a murine model of necrotizing pneumonia

Journal of Infectious Diseases

Volumn 201, Issue 6, 2010, Pages 967-969

  Vandenesch, François ^a,d   Couzon, Florence ^a   Boisset, Sandrine ^a   Benito, Yvonne ^a   Brown, Eric L ^b   Lina, Gerard ^a   Etienne, Jerome ^a   Gabriela Bowden, M ^c  

^a UNIVERSITÉ DE LYON   (France)

^b UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF TEXAS   (United States)

^d UNIVERSITÉ LYON 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; PANTON VALENTINE LEUKOCIDIN;

BACTERIAL STRAIN; BACTERIAL VIRULENCE; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; LETTER; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA TRANSCRIPTION;

ANIMALS; BACTERIAL PROTEINS; BACTERIAL TOXINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EXOTOXINS; HUMANS; LEUKOCIDINS; MICE; PNEUMONIA, STAPHYLOCOCCAL; POINT MUTATION; STAPHYLOCOCCUS AUREUS; TRANS-ACTIVATORS; VIRULENCE; VIRULENCE FACTORS;

EID: 77749265005     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/651026     Document Type: Letter

References (7)

1. Villaruz AE, Bubeck Wardenburg J, Khan BA, et al. A point mutation in the agr locus rather than expression of the Panton-Valentine leukocidin caused previously reported phenotypes in Staphylococcus aureus pneumonia and gene regulation. J Infect Dis 2009; 200:724-734.
2. Labandeira-Rey M, Couzon F, Boisset S, et al. Staphylococcus aureus Panton-Valentine leukocidin causes necrotizing pneumonia. Science 2007; 315:1130-1133.
3. Badiou Q Dumitrescu O, Croze M, et al. Panton-Valentine leukocidin is expressed at toxic levels in human skin abscesses. Clin Microbiol Infect 2008; 14:1180-1183.
4. Brown EL, Dumitrescu O, Thomas D, et al. The Panton-Valentine leukocidin vaccine protects mice against lung and skin infections caused by Staphylococcus aureus USA300. Clin Microbiol Infect 2009; 15:156-164.
5. Hongo I, Baba T, Oishi K, et al. Phenol-soluble modulin α3 enhances the human neutrophil lysis mediated by Panton-Valentine leukocidin. J Infect Dis 2009;200:715-723.
6. Tseng CW, Kyme P, Low J, et al. Staphylococcus aureus Panton-Valentine leukocidin contributes to inflammation and muscle tissue injury. PLoS One 2009; 4:e6387.
7. Benito Y, Lina G, Greenland T, Etienne J, Vandenesch F. trans-Complementation of a Staphylococcus aureus agr mutant by Staphylococcus lugdunensis agr RNAIII. J Bacteriol 1998; 180: 5780-5783.