The use of prophylactic vancomycin to prevent MRSA colonization: Does this double-edged sword promote future vancomycin resistance or is it a safe preventative strategy that should be used in all patients in the context of MRSA endemicity?

Minerva Anestesiologica

Volumn 76, Issue 3, 2010, Pages 175-177

  Li Bassi, G ^a   Saucedo, L M ^a  

^a HOSPITAL CLÍNIC   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

VANCOMYCIN;

ANTIBIOTIC PROPHYLAXIS; ANTIBIOTIC RESISTANCE; ANTIBIOTIC THERAPY; BACTERIAL COLONIZATION; DRUG SAFETY; EDITORIAL; INFECTION CONTROL; INFECTION PREVENTION; INFECTION RISK; INTENSIVE CARE UNIT; LOWER RESPIRATORY TRACT INFECTION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS INFECTION; OROPHARYNX; SPECIES ENDEMICITY;

ANTI-BACTERIAL AGENTS; ANTIBIOTIC PROPHYLAXIS; CROSS INFECTION; HUMANS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCAL INFECTIONS; VANCOMYCIN;

EID: 77749242694     PISSN: 03759393     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Editorial

References (18)

1. Parker MT, Jevons MP. A survey of methicillin resistance in Staphylococcus aureus. Postgrad Med J 1964;40:Suppl 8.
2. Malacarne P, Boccalatte D, Acquarolo A, Agostini F, Anghileri A, Giardino M et al. Epidemiology of nosocomial infection in 125 italian intensive care units. Minerva Anestesiol 2010;76:13-23.
3. Silvestri L, Solidoro A, Milanese M, Van Saene HKF, Fontana F, De Gregori D et al. Topical oropharyngeal vancomycin to control methicillin-resistant Staphylococcus aureus lower airway infection in ventilated patients. Minerva Anestesiol 2010;76:193-202.
4. Cerda E, Abella A, de la Cal MA, Lorente JA, García-Hierro P, van Saene HK et al. Enteral vancomycin controls methicillinresistant Staphylococcus aureus endemicity in an intensive care burn unit: a 9-year prospective study. Ann Surg 2007;245:397-407.
5. De la Cal MA, Cerda E, van Saene HK, García-Hierro P, Negro E, Parra ML et al. Effectiveness and safety of enteral vancomycin to control endemicity of methicillin-resistant Staphylococcus aureus in a medical/surgical intensive care unit. J Hosp Infect 2004;56:175-83.
6. Silvestri L, Milanese M, Oblach L, Fontana F, Gregori D, Guerra R et al. Enteral vancomycin to control methicillinresistant Staphylococcus aureus outbreak in mechanically ventilated patients. Am J Infect Control 2002;30:391-9.
7. Silvestri L, van Saene HK, Milanese M, Fontana F, Gregori D, Oblach L et al. Prevention of MRSA pneumonia by oral vancomycin decontamination: a randomised trial. Eur Respir J 2004;23:921-6.
8. Thorburn K, Taylor N, Saladi SM, van Saene HK. Use of surveillance cultures and enteral vancomycin to control methicillin-resistant Staphylococcus aureus in a paediatric intensive care unit. Clin Microbiol Infect 2006;12:35-42.
9. De Smet AM, Kluytmans JA, Cooper BS, Mascini EM, Benus RF, van der Werf TS et al. Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med 2009;360:20-31.
10. de Jonge E, Schultz MJ, Spanjaard L, Bossuyt PM, Vroom MB, Dankert J et al. Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial. Lancet 2003;362:1011-6.
11. Viviani M, van Saene HK, Dezzoni R, Silvestri L, Di Lenarda R, Berlot G et al. Control of imported and acquired methicillin-resistant Staphylococcus aureus (MRSA) in mechanically ventilated patients: a dose-response study of enteral vancomycin to reduce absolute carriage and infection. Anaesth Intensive Care 2005;33:361-72.
12. Tenover FC, Moellering RC, Jr. The rationale for revising the Clinical and Laboratory Standards Institute vancomycin minimal inhibitory concentration interpretive criteria for Staphylococcus aureus. Clin Infect Dis 2007;44:1208-15.
13. Wootton M, Howe RA, Hillman R, Walsh TR, Bennett PM, MacGowan AP. A modified population analysis profile (PAP) method to detect hetero-resistance to vancomycin in Staphylococcus aureus in a UK hospital. J Antimicrob Chemother 2001;47:399-403.
14. Liu C, Chambers HF. Staphylococcus aureus with heterogeneous resistance to vancomycin: epidemiology, clinical significance, and critical assessment of diagnostic methods. Antimicrob Agents Chemother 2003;47:3040-5.
15. Brenwald NP, Baker N, Oppenheim B. Feasibility study of a real-time PCR test for meticillin-resistant Staphylococcus aureus in a point of care setting. J Hosp Infect 2009 Nov 13. [Epub ahead of print].
16. Chen L, Mediavilla JR, Oliveira DC, Willey BM, de LH, Kreiswirth BN. Multiplex real-time PCR for rapid Staphylococcal cassette chromosome mec typing. J Clin Microbiol 2009;47:3692-706.
17. Dalla VC, Pasca MR, De VD, Marzani FC, Emmi V, Marone P. Control of MRSA infection and colonisation in an intensive care unit by GeneOhm MRSA assay and culture methods. BMC Infect Dis 2009;9:137.
18. Weigel LM, Clewell DB, Gill SR, Clark NC, McDougal LK, Flannagan SE et al. Genetic analysis of a high-level vancomycin-resistant isolate of Staphylococcus aureus. Science 2003;302:1569-71.