Generation of anti-proteinase 3 monoclonal antibodies and development of immunological methods to detect endogenous proteinase 3

Hybridoma

Volumn 29, Issue 1, 2010, Pages 17-26

  Bae, Suyoung ^a   Choi, Jida ^a   Hong, Jaewoo ^a   Lee, Siyoung ^b   Her, Erk ^b   Choi, Wonhyuk ^b   Kim, Sangmin ^b   Choi, Youngbum ^b   Kim, Soohyun ^a  

^a Konkuk University   (South Korea)

^b Konkuk University School of Medicine   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME ANTIBODY; MONOCLONAL ANTIBODY; MYELOBLASTIN; RECOMBINANT ENZYME;

ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ARTICLE; BLOOD ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; ENZYME ANALYSIS; ENZYME PURIFICATION; ENZYME SYNTHESIS; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; IMMUNOASSAY; IMMUNOBLOTTING; IMMUNOFLUORESCENCE TEST; MOLECULAR RECOGNITION; MOUSE; NEUTROPHIL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REDUCTION; SENSITIVITY AND SPECIFICITY; URINALYSIS;

ANIMALS; ANTIBODIES, MONOCLONAL; BLOTTING, WESTERN; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; HYBRIDOMAS; IMMUNIZATION; IMMUNOENZYME TECHNIQUES; MICE; MICE, INBRED BALB C; MYELOBLASTIN; PLASMIDS; RECOMBINANT PROTEINS;

ESCHERICHIA COLI;

EID: 77749233889     PISSN: 15540014     EISSN: None     Source Type: Journal    
DOI: 10.1089/hyb.2009.0054     Document Type: Article

References (30)

1. Baggiolini, M, Bretz U, Dewald B, and Feigenson ME: The polymorphonuclear leukocyte. Agents Actions 1978;8: 3-10.
2. Preston, GA, Zarella CS, Pendergraft WF, 3rd, Rudolph EH, Yang JJ, Sekura SB, Jennette JC, and Falk RJ: Novel effects of neutrophil-derived proteinase 3 and elastase on the vascular endothelium involve in vivo cleavage of NF-kappaB and proapoptotic changes in JNK, ERK, and p38 MAPK signaling pathways. J Am Soc Nephrol 2002;13:2840-2849.
3. Padrines M, Wolf ZM, Walz A, and Baggiolini M: Interleukin-8 processing by neutrophil elastase, cathepsin G and proteinase-3. FEBS Lett 1994;352:231-235.
4. Csernok E, Szymkowiak CH, Mistry N, Daha MR, Gross WL, and Kekow J: Transforming growth factor-beta (TGF-beta) expression and interaction with proteinase 3 (PR3) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Clin Exp Immunol 1996;105:104-111.
5. Robache-Gallea S, Morand V, Bruneau JM, Schoot B, Tagat E, Realo E, Chouaib S, and Roman-Roman S: In vitro processing of human tumor necrosis factor-alpha. J Biol Chem 1995;270:23688-23692.
6. Coeshott C, Ohnemus C, Pilyavskaya A, Ross S, Wieczorek M, Kroona H, Leimer AH, and Cheronis J: Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3. Proc Natl Acad Sci USA 1999;96:6261-6266.
7. Sugawara S, Uehara A, Nochi T, Yamaguchi T, Ueda H, Sugiyama A, Hanzawa K, Kumagai K, Okamura H, and Takada H: Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells. J Immunol 2001;167:6568-6575.
8. Ramaha A, and Patston PA: Release and degradation of angiotensin I and angiotensin II from angiotensinogen by neutrophil serine proteinases. Arch Biochem Biophys 2002; 397:77-83.
9. Frosch M, and Foell D: Wegener granulomatosis in childhood and adolescence. Eur J Pediatr 2004;163:425-434.
10. Jennette JC, and Falk RJ: Diagnosis and management of glomerular diseases. Med Clin North Am 1997;81:653-677.
11. Pendergraft WF, 3rd, Rudolph EH, Falk RJ, Jahn JE, Grimmler M, Hengst L, Jennette JC, and Preston GA: Pro-teinase 3 sidesteps caspases and cleaves p21(Waf1/Cip1/Sdi1) to induce endothelial cell apoptosis. Kidney Int 2004; 65:75-84.
12. Pendergraft WF, 3rd, Preston GA, Shah RR, Tropsha A, Carter CW, Jr, Jennette JC, and Falk RJ: Autoimmunity is triggered by cPR-3(105-201), a protein complementary to human autoantigen proteinase-3. Nat Med 2004;10:72-79.
13. Witko-Sarsat V, Lesavre P, Lopez S, Bessou G, Hieblot C, Prum B, Noel LH, Guillevin L, Ravaud P, Sermet-Gaudelus I, Timsit J, Grunfeld JP, and Halbwachs-Mecarelli L: A large subset of neutrophils expressing membrane proteinase 3 is a risk factor for vasculitis and rheumatoid arthritis. J Am Soc Nephrol 1999;10:1224-1233.
14. Muller Kobold AC, Kallenberg CG, and Tervaert JW: Leucocyte membrane expression of proteinase 3 correlates with disease activity in patients with Wegener's granulomatosis. Br J Rheumatol 1998;37:901-907.
15. Yang JJ, Preston GA, Alcorta DA, Waga I, Munger WE, Hogan SL, Sekura SB, Phillips BD, Thomas RP, Jennette JC, and Falk RJ: Expression profile of leukocyte genes activated by anti-neutrophil cytoplasmic autoantibodies (ANCA). Kidney Int 2002;62:1638-1649.
16. Just J, Moog-Lutz C, Houzel-Charavel A, Canteloup S, Grimfeld A, Witko-Sarsat V, and Cayre YE: Proteinase 3 mRNA expression is induced in monocytes but not in neu-trophils of patients with cystic fibrosis. FEBS Lett 1999;457: 437-440.
17. von Bredow C, Wiesener A, and Griese M: Proteolysis of surfactant protein D by cystic fibrosis relevant proteases. Lung 2003;181:79-88.
18. Uehara A, Sugawara Y, Sasano T, Takada H, and Sugawara S: Proinflammatory cytokines induce proteinase 3 as membrane-bound and secretory forms in human oral epithelial cells and antibodies to proteinase 3 activate the cells through protease-activated receptor-2. J Immunol 2004; 173:4179-4189.
19. Zimmerman T, Petit Frere C, Satzger M, Raba M, Weisbach M, Dohn K, Popp A, and Donzeau M: Simultaneous metal chelate affinity purification and endotoxin clearance of recombinant antibody fragments. J Immunol Methods 2006; 314:67-73.
20. Dengler R, Munstermann U, al-Batran S, Hausner I, Faderl S, Nerl C, and Emmerich B: Immunocytochemical and flow cytometric detection of proteinase 3 (myeloblastin) in normal and leukaemic myeloid cells. Br J Haematol 1995;89:250-257.
21. Goldschmeding R, van der Schoot CE, ten Bokkel Huinink D, Hack CE, van den Ende ME, Kallenberg CG, and von dem Borne AE: Wegener's granulomatosis autoantibodies identify a novel diisopropylfluorophosphate-binding protein in the lysosomes of normal human neutrophils. J Clin Invest 1989;84:1577-1587.
22. Garwicz D, Lindmark A, Hellmark T, Gladh M, Jogi J, and Gullberg U: Characterization of the processing and granular targeting of human proteinase 3 after transfection to the rat RBL or the murine 32D leukemic cell lines. J Leukoc Biol 1997;61:113-123.
23. Rao NV, Rao GV, Marshall BC, and Hoidal JR: Biosynthesis and processing of proteinase 3 in U937 cells. Processing pathways are distinct from those of cathepsin G. J Biol Chem 1996;271:2972-2978.
24. McGuire MJ, Lipsky PE, and Thiele DL: Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl pepti-dase I. J Biol Chem 1993;268:2458-2467.
25. Lindmark A, Garwicz D, Rasmussen PB, Flodgaard H, and Gullberg U: Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin. J Leukoc Biol 1999;66:634-643.
26. Lindmark A, Persson AM, and Olsson I: Biosynthesis and processing of cathepsin G and neutrophil elastase in the leukemic myeloid cell line U-937. Blood 1990;76:2374-2380.
27. Fujinaga M, Chernaia MM, Halenbeck R, Koths K, and James MN: The crystal structure of PR3, a neutrophil serine proteinase antigen of Wegener's granulomatosis antibodies. J Mol Biol 1996;261:267-278.
28. Novick D, Rubinstein M, Azam T, Rabinkov A, Dinarello CA, and Kim SH: Proteinase 3 is an IL-32 binding protein. Proc Natl Acad Sci USA 2006;103:3316-3321.
29. Elliott PR, Lomas DA, Carrell RW, and Abrahams JP: Inhibitory conformation of the reactive loop of alpha 1-antitrypsin. Nat Struct Biol 1996;3:676-681.
30. Ye S, Cech AL, Belmares R, Bergstrom RC, Tong Y, Corey DR, Kanost MR, and Goldsmith EJ: The structure of a Michaelis serpin-protease complex. Nat Struct Biol 2001;8:979-983.