The Toll immune signaling pathway control conserved anti-dengue defenses across diverse Ae. aegypti strains and against multiple dengue virus serotypes

Developmental and Comparative Immunology

Volumn 34, Issue 6, 2010, Pages 625-629

  Ramirez, Jose L ^a   Dimopoulos, George ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Arbovirus; Dengue; Innate immunity; Toll pathway

Indexed keywords

CELL PROTEIN; PROTEIN TOLL; UNCLASSIFIED DRUG;

AEDES AEGYPTI; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DENGUE VIRUS; IMMUNOREGULATION; INNATE IMMUNITY; INSECT CELL; NONHUMAN; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SEROTYPE; SIGNAL TRANSDUCTION; STRAIN DIFFERENCE; VIRION; VIRUS CELL INTERACTION; VIRUS STRAIN; VIRUS TRANSMISSION;

AEDES AEGYPTI; ARBOVIRUS; DENGUE VIRUS;

EID: 77649342030     PISSN: 0145305X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.dci.2010.01.006     Document Type: Article

References (21)

1. Gubler D.J., and Rosen L. Variation among geographic strains of Aedes albopictus in suceptibility to infection with dengue viruses. American Journal of Tropical Medicine and Hygiene 25 2 (1976) 318-325
2. Hardy J.L. Susceptibility and resistance of vector mosquitoes. In: Monath T.P. (Ed). The arboviruses: epidemiology and ecology, 1 (1988) 87-126
3. Salazar M.I., Richardson J., Sanchez-Vargas I., Olson K., and Beaty B. Dengue virus type 2: replication and tropisms in orally infected Aedes aegypti mosquitoes. BMC Microbiology 7 1 (2007) 9
4. Anderson J.R., and Rico-Hesse R. Aedes aegypti vectorial capacity is determined by the infecting genotype of dengue virus. American Journal of Tropical Medicine and Hygiene 75 5 (2006) 886-892
5. Hanley K.A., Goddard L.B., Gilmore L.E., Scott T.W., Speicher J., Murphy B.R., et al. Infectivity of West Nile/Dengue chimeric viruses for West Nile and dengue mosquito vectors. Vector-Borne and Zoonotic Diseases 5 1 (2005) 1-10
6. Armstrong P.M., and Rico-Hesse R. Efficiency of dengue serotype 2 virus strains to infect and disseminate in Aedes aegypti. American Journal of Tropical Medicine and Hygiene 68 5 (2003) 539-544
7. Mosso C., Galván-Mendoza I.J., Ludert J.E., and del Angel R.M. Endocytic pathway followed by dengue virus to infect the mosquito cell line C6/36 HT. Virology 378 1 (2008) 193
8. Black W.C., Bennett K.E., Gorrochótegui-Escalante N., Barillas-Mury C.V., Fernández-Salas I., de Lourdes Muñoz M., et al. Flavivirus susceptibility in Aedes aegypti. Archives of Medical Research 33 4 (2002) 379
9. Richardson J., Molina-Cruz A., Salazar M.I., and Black W.I. Quantitative analysis of dengue-2 virus RNA during the extrinsic incubation period in individual Aedes aegypti. American Journal of Tropical Medicine and Hygiene 74 1 (2006) 132-141
10. Bennett K., Flick D., Fleming K.H., Jochim R., Beaty B., and Black W.C. Quantitative trait loci that control Dengue-2 virus dissemination in the mosquito Aedes aegypti. Genetics 170 (2005) 185-194
11. Lehane M.J., Aksoy S., and Levashina E. Immune responses and parasite transmission in blood-feeding insects 20 9 (2004) 433
12. De Gregorio E., Spellman P.T., Tzou P., Rubin G.M., and Lemaitre B. The Toll and Imd pathways are the major regulators of the immune response in Drosophila. EMBO Journal 21 11 (2002) 2568
13. Xi Z., Ramirez J.L., and Dimopoulos G. The Aedes aegypti Toll pathway controls dengue virus infection. PLoS Pathogens 4 7 (2008) e1000098
14. Souza-Neto J.A., Sim S., and Dimopoulos G. An evolutionary conserved function of the JAK-STAT pathway in anti-dengue defense. Proceedings of the National Academy of Sciences (2009)
15. Sanchez-Vargas I., Scott J.C., Poole-Smith B.K., Franz A.W.E., Barbosa-Solomieu V., Wilusz J., et al. Dengue virus type 2 infections of Aedes aegypti are modulated by the mosquito's RNA interference pathway. PLoS Pathogens 5 2 (2009) e1000299
16. Troyer J.M., Hanley K.A., Whitehead S.S., Strickman D., Karron R.A., Durbin A.P., et al. A live attenuated recombinant dengue-4 virus vaccine candidate with restricted capacity for dissemination in mosquitoes and lack of transmission from vaccinees to mosquitoes. American Journal of Tropical Medicine and Hygiene 65 5 (2001) 414-419
17. Billoir F., de Chesse R., Tolou H., de Micco P., Gould E.A., and de Lamballerie X. Phylogeny of the genus Flavivirus using complete coding sequences of arthropod-borne viruses and viruses with no known vector. The Journal of General Virology 81 3 (2000) 781-790
18. Zanotto P.M., Gould E.A., Gao G.F., Harvey P.H., and Holmes E.C. Population dynamics of flaviviruses revealed by molecular phylogenies. Proceedings of the National Academy of Sciences of the United States of America 93 2 (1996) 548-553
19. Rodríguez M.M., Bisset J., de Fernandez D.M., Lauzán L., and Soca A. Detection of insecticide resistance in Aedes aegypti (Diptera: Culicidae) from Cuba and Venezuela. Journal of Medical Entomology 38 5 (2009) 623
20. Zambon R.A., Nandakumar M., Vakharia V.N., and Wu L.P. The Toll pathway is important for an antiviral response in Drosophila. Proceedings of the National Academy of Sciences of the United States of America 102 20 (2005) 7257-7262
21. Sanders H.R., Foy B.D., Evans A.M., Ross L.S., Beaty B.J., Olson K.E., et al. Sindbis virus induces transport processes and alters expression of innate immunity pathway genes in the midgut of the disease vector, Aedes aegypti. Insect Biochemistry and Molecular Biology 35 11 (2005) 1293