Editorial: How does sunitinib cause hypothyroidism?

Thyroid

Volumn 20, Issue 3, 2010, Pages 243-244

  Hershman, Jerome M ^a   Liwanpo, Llanyee ^a  

^a VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEVOTHYROXINE; RADIOACTIVE IODINE; SUNITINIB; THYROID PEROXIDASE; THYROTROPIN; ANTINEOPLASTIC AGENT; INDOLE DERIVATIVE; PYRROLE DERIVATIVE;

DOWN REGULATION; EDITORIAL; ENZYME ACTIVITY; GASTROINTESTINAL STROMAL TUMOR; HUMAN; HYPOTHYROIDISM; KIDNEY CARCINOMA; PRIORITY JOURNAL; THYROID WEIGHT; THYROIDITIS; VASOCONSTRICTION; CHEMICALLY INDUCED DISORDER; KIDNEY TUMOR; NOTE;

ANTINEOPLASTIC AGENTS; CARCINOMA, RENAL CELL; HUMANS; HYPOTHYROIDISM; INDOLES; KIDNEY NEOPLASMS; PYRROLES;

EID: 77649329347     PISSN: 10507256     EISSN: None     Source Type: Journal    
DOI: 10.1089/thy.2010.1620     Document Type: Editorial

References (15)

1. Rogiers A, Wolter P, Op de Beeck K, Thijs M, Decallone B, Schöffski P 2010 Shrinkage of thyroid volume in sunitinib treated patients with renal cell carcinoma - a potential marker of irreversible thyroid dysfunction? Thyroid 20: 317-322.
2. Makita N, Miyakawa, M, Fujita T, Iiri T 2010 Sunitinib induces hypothyroidism with a markedly reduced vascularity. Thyroid 20:323-326.
3. Wong E, Rosen LS, Mulay M, Vanvugt A, Dinolfo M, Tomoda C, Sugawara M, Hershman JM 2007 Sunitinib induces hypothyroidism in advanced cancer patients and may inhibit thyroid peroxidase activity. Thyroid 17:351-355.
4. Rini BI, Tamaskar I, Shaheen P, Salas R, Garcia J, Wood L, Reddy S, Dreicer R, Bukowski RM 2007 Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst 99:81-83.
5. Feldman DR, Martorella AJ, Robbins RJ, Motzer RJ 2007 Re: Hypothyroidism in patients with metastatic renal cell carcinoma treated with sunitinib. J Natl Cancer Inst 99:974-975; author reply 976-977.
6. Desai J, Yassa L, Marqusee E, George S, Frates MC, Chen MH, Morgan JA, Dychter SS, Larsen PR, Demetri GD, Alexander EK 2006 Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors. Ann Intern Med 145:660-664.
7. Mannavola D, Coco P, Vannucchi G, Bertuelli R, Carletto M, Casali PG, Beck-Peccoz P, Fugazzola L 2007 A novel tyro-sine-kinase selective inhibitor, sunitinib, induces transient hypothyroidism by blocking iodine uptake. J Clin Endocrinol Metab 92:3531-3534.
8. Wolter P, Stefan C, Decallonne B, Dumez H, Bex M, Carmeliet P, Schoffski P 2008 The clinical implications of sunitinib-induced hypothyroidism: a prospective evaluation. Br J Cancer 99:448-454.
9. Faris JE, Moore AF, Daniels GH 2007 Sunitinib (sutent)-induced thyrotoxicosis due to destructive thyroiditis: a case report. Thyroid 17:1147-1149.
10. Alexandrescu DT, Popoveniuc G, Farzanmehr H, Dasanu CA, Dawson N, Wartofsky L 2008 Sunitinib-associated lymphocytic thyroiditis without circulating antithyroid antibodies. Thyroid 18:809-812.
11. Grossmann M, Premaratne E, Desai J, Davis ID 2008 Thyrotoxicosis during sunitinib treatment for renal cell carcinoma. Clin Endocrinol (Oxf) 69:669-672.
12. de Groot JW, Zonnenberg BA, Plukker JT, van Der Graaf WT, Links TP 2005 Imatinib induces hypothyroidism in patients receiving levothyroxine. Clin Pharmacol Ther 78:433-438.
13. Sherman SI, Wirth LJ, Droz JP, Hofmann M, Bastholt L, Martins RG, Licitra L, Eschenberg MJ, Sun YN, Juan T, Stepan DE, Schlumberger MJ 2008 Motesanib diphosphate in progressive differentiated thyroid cancer. N Engl J Med 359:31-42.
14. Salem AK, Fenton MS, Marion KM, Hershman JM 2008 Effect of sunitinib on growth and function of FRTL-5 thyroid cells. Thyroid 18:631-635.
15. Kamba T, Tam BY, Hashizume H, Haskell A, Sennino B, Mancuso MR, Norberg SM, O'Brien SM, Davis RB, Gowen LC, Anderson KD, Thurston G, Joho S, Springer ML, Kuo CJ, McDonald DM 2006 VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol 290:H560-576.