Editorial: Can the FMR1 gene predict early ovarian aging?

Women's Health

Volumn 6, Issue 2, 2010, Pages 165-169

  Gleicher, Norbert ^a,b   Barad, David H ^a,c  

^a New York and Foundation for Reproductive Medicine   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOSINE; GUANINE; FMR1 PROTEIN, HUMAN; FRAGILE X MENTAL RETARDATION PROTEIN;

AGING; AUTOIMMUNITY; DISEASE SEVERITY; EDITORIAL; ETHNIC DIFFERENCE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; FMR1 GENE; GENE; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC SCREENING; HETEROZYGOTE; HOMOZYGOTE; HUMAN; NEUROPSYCHIATRY; OVARY FOLLICLE; OVARY INSUFFICIENCY; POPULATION GENETICS; PREDICTION; PREMATURE OVARIAN FAILURE; RISK ASSESSMENT; RNA TRANSLATION; ADULT; EARLY MENOPAUSE; FEMALE; GENETICS; HEALTH SERVICE; ORGANIZATION AND MANAGEMENT; RISK FACTOR; TRINUCLEOTIDE REPEAT; WOMEN'S HEALTH;

ADULT; FEMALE; FRAGILE X MENTAL RETARDATION PROTEIN; HUMANS; MENOPAUSE, PREMATURE; OVARIAN FAILURE, PREMATURE; RISK FACTORS; TRINUCLEOTIDE REPEAT EXPANSION; WOMEN'S HEALTH; WOMEN'S HEALTH SERVICES;

EID: 77649276349     PISSN: 17455057     EISSN: 17455065     Source Type: Journal    
DOI: 10.2217/whe.09.85     Document Type: Editorial

References (20)

1. Wittenberger MD, Hagerman RJ, Sherman SL et al.: The FMR1 premutation and reproduction Fertil. Steril. 87, 456-465 (2007).
2. Fu YH, Kuhl DP, Pizzuti A et al.: Variation of the CGG repeat at the fragile X site results in genetic instability: resolution of the Sherman paradox. Cell 67, 1047-1058 (1991).
3. Chen LS, Tassone F, Sahota P, Hagerman PJ: The (CGG)n repeat element within the 5′ untranslated region of the FMR1 message provides both positive and negative cis effects on in vivo translation of a downstream reporter. Hum. Mol. Genet. 12, 3067-3074 (2003).
4. Bodega B, Bione S, Dalpra L et al.: Influence of intermediate and uninterrupted FMR1 CGG expansions in premature ovarian failure manifestation. Hum. Reprod. 21, 952-957 (2006).
5. Bretherick KL, Fluker MR, Robinson WP: FMR1 repeat sizes in the gray zone and high end of the normal range are associated with premature ovarian failure. Hum. Genet. 117, 376-382 (2005).
6. Nelson LM: Clinical practice. Primary ovarian insufficiency. N. Engl. J. Med. 360, 606-614 (2009).
7. Gleicher N, Weghofer A, Barad DH: A pilot study of premature ovarian senescence: I. correlation of triple CGG repeats on the FMR1 gene to ovarian reserve parameters FSH and anti-Müllerian hormone. Fertil. Steril. 91, 1700-1706 (2009).
8. Gleicher N, Weghofer A, Barad DH: A pilot study of premature ovarian senescence: II. different genotype and phenotype for genetic and autoimmune etiologies. Fertil. Steril. 91, 1707-1711 (2009).
9. Hoek A, Schoemaker J, Drexhage HA: Premature ovarian failure and ovarian autoimmunity. Endocrin. Rev. 18, 107-134 (1997).
10. Gleicher N, Weghofer A, Oktay K, Barad D: Do etiologies of premature ovarian aging (POA) mimic those of premature ovarian failure (POF)? Hum. Reprod. 24, 2395-2400 (2009).
11. Gleicher N, Weghofer A, Oktay K, Barad DH: Can the FMR1 (fragile X) gene serve as predictor of response to ovarian stimulation? Reprod. Science 16, 462-467 (2009).
12. Barad DH, Weghofer A, Gleicher N: Age-specific levels for basal follicle-stimulating hormone assessment of ovarian function. Obstet. Gynecol. 109, 1404-1410 (2007).
13. Gleicher N, Weghofer A, Oktay K, Barad DH: Correlation of triple repeats on the FMR1 (fragile X) gene to ovarian reserve: a new infertility test? Acta Obstet. Gynecol. Scand. 88, 1024-1030 (2009).
14. Gleicher N, Weghofer A, Oktay K, Barad D: Relevance of triple CGG repeats in the FMR1 gene to ovarian reserve. Reprod. Biomed. Online 19, 385-390 (2009).
15. Gleicher N, Weghofer A, Barad DH: Effects of race/ethnicity on triple CGG counts on FMR1 gene in infertile women and egg donors. Reprod. Biomed. Online (2010) (In press).
16. Gleicher N, Weghofer A, Barad DH: Ovarian reserve determinations suggest new function of FMR1 (fragile X) gene in regulating ovarian aging. Reprod. Biomed. Online (2010) (In press).
17. Barad DH, Weghofer A, Gleicher N: Comparing anti-Müllerian hormone (AMH) and follicle-stimulating hormone (FSH) as predictors of ovarian function. Fertil. Steril. 91, 1553-1555 (2009).
18. van Disseldorp J, Faddy MJ, Themmen AP et al.: Relationship of serum antimüllerian hormone concentration to age at menopause. J. Clin. Endocrinol. Metab. 93, 2129-2134 (2008).
19. Streuli I, Fraisse T, Ibecheole V, Moix I, Morris MA, de Ziegler D: Intermediate and premutation FMR1 alleles in women with occult primary ovarian insufficiency. Fertil. Steril. 92, 464-470 (2009).
20. Chatterjee S, Maitra A, Kadam S, Patel Z, Gokral J, Meherji P: CGG repeat sizing in the FMR1 gene in Indian women with premature ovarian failure. Reprod. Biomed. Online 19, 281-286 (2009).